Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

1991 • 855 citations

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

1987 • 412 citations

Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse.

1990 • 292 citations

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

1987 • 291 citations

An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma.

1990 • 234 citations

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

1988 • 213 citations

Phase I Study and Pharmacokinetics of CPT-11 With 5-Day Continuous Infusion

1992 • 122 citations

[A phase II study of CPT-11, a camptothecin derivative, in patients with primary lung cancer. CPT-11 Cooperative Study Group].

1991 • 91 citations

[A late phase II study of CPT-11 on uterine cervical cancer and ovarian cancer. Research Groups of CPT-11 in Gynecologic Cancers].

1991 • 82 citations

[Antitumor activity of CPT-11 against rat Walker 256 carcinoma].

1988 • 19 citations