Target recognition failure by the nonspecific defense system: surface constituents of pathogens interfere with the alternative pathway of complement activation

Dyes as Microchemical Indicators of a New Immunity Phenomenon Affecting a Protozoon Parasite (Toxoplasma)

1948 • 918 citations

MOLECULAR ORGANIZATION AND FUNCTION OF THE COMPLEMENT SYSTEM

1988 • 831 citations

Current Knowledge of Type-Specific M Antigens of Group A Streptococci

1962 • 793 citations

Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes.

1983 • 495 citations

Antiphagocytic activity of streptococcal M protein: selective binding of complement control protein factor H.

1988 • 458 citations

Complement receptor type three (CD11b/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen.

1988 • 457 citations

Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H.

1990 • 416 citations

Regulation by membrane sialic acid of β1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway

1978 • 415 citations

A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite

1988 • 386 citations

Molecular basis for trypanosome antigenic variation

1982 • 369 citations

Membrane Complement Receptors Specific for Bound Fragments of C3

1985 • 311 citations

Complement Evasion by Bacteria and Parasites

1988 • 300 citations

The alternative pathway of complement

1984 • 294 citations

Microbial surfaces in relation to pathogenicity

1977 • 293 citations

Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors.

1987 • 287 citations

Role of the adherence-promoting receptors, CR3, LFA-1, and p150,95, in binding of Histoplasma capsulatum by human macrophages.

1987 • 259 citations

CR1, the C3b receptor, mediates binding of infective Leishmania major metacyclic promastigotes to human macrophages.

1989 • 258 citations

The mouse macrophage receptor for C3bi (CR3) is a major mechanism in the phagocytosis of Leishmania promastigotes.

1985 • 258 citations

Microbial glycolipids: possible virulence factors that scavenge oxygen radicals.

1989 • 255 citations

The Leishmania receptor for macrophages is a lipid-containing glycoconjugate.

1985 • 235 citations

Human serum lyses RNA tumour viruses

1975 • 222 citations

Capsular sialic acid prevents activation of the alternative complement pathway by type III, group B streptococci.

1982 • 210 citations

Complement binding by two developmental stages of Leishmania major promastigotes varying in expression of a surface lipophosphoglycan.

1988 • 202 citations

The third component of complement (C3) is responsible for the intracellular survival of Leishmania major

1987 • 198 citations

Surface acid proteinase (gp63) of Leishmania mexicana

1989 • 196 citations

Identification of an epitope in the major envelope protein of Epstein-Barr virus that mediates viral binding to the B lymphocyte EBV receptor (CR2)

1989 • 191 citations

Sialic acid of group B Neisseria meningitidis regulates alternative complement pathway activation

1987 • 186 citations

Glycoprotein C of herpes simplex virus 1 is an inhibitor of the complement cascade.

1986 • 177 citations

Plasmid-determined resistance to serum bactericidal activity: a major outer membrane protein, the traT gene product, is responsible for plasmid-specified serum resistance in Escherichia coli

1980 • 172 citations

Herpes simplex virus glycoproteins gC-1 and gC-2 bind to the third component of complement and provide protection against complement-mediated neutralization of viral infectivity.

1987 • 168 citations

Pathogenesis of Campylobacter fetus infections. Failure of encapsulated Campylobacter fetus to bind C3b explains serum and phagocytosis resistance.

1988 • 164 citations

Candida albicans and Candida stellatoidea, in contrast to other Candida species, bind iC3b and C3d but not C3b

1985 • 162 citations

Antiopsonic activity of fibrinogen bound to M protein on the surface of group A streptococci.

1982 • 160 citations

Separation of self from non-self in the complement system

1987 • 159 citations

The promastigote surface protease of leishmania

1987 • 154 citations

Monoclonal antibody affinity purification of a Leishmania membrane glycoprotein and its inhibition of leishmania-macrophage binding.

1986 • 149 citations

Lipophosphoglycan from Leishmania mexicana promastigotes binds to members of the CR3, p150,95 and LFA-1 family of leukocyte integrins.

1990 • 146 citations

The membrane attack complex

1984 • 145 citations

Characterization of a Trypanosoma cruzi C3 binding protein with functional and genetic similarities to the human complement regulatory protein, decay-accelerating factor.

1991 • 143 citations

Genetic analysis of virulence plasmid from a serogroup 9 Yersinia enterocolitica strain: role of outer membrane protein P1 in resistance to human serum and autoagglutination

1985 • 142 citations

Expression of specific binding sites on Candida with functional and antigenic characteristics of human complement receptors.

1986 • 134 citations

Endogenous sialylation of the lipooligosaccharides of Neisseria meningitidis

1991 • 133 citations

Homologous species restriction in lysis of erythrocytes by terminal complement proteins.

1981 • 129 citations

Acid protease activity of a major surface membrane glycoprotein (gp63) from Leishmania mexicana promastigotes

1988 • 124 citations

Cytidine 5'-Monophospho-N-acetylneuraminic Acid or a Related Compound is the Low Mr Factor from Human Red Blood Cells Which Induces Gonococcal Resistance to Killing by Human Serum

1988 • 119 citations

The macrophage-attachment glycoprotein gp63 is the predominant C3-acceptor site on Leishmania mexicana promastigotes

1987 • 110 citations

Alternative pathway activation of complement by African trypanosomes lacking a glycoprotein coat

1983 • 104 citations

Localization of the third component of complement on the cell wall of encapsulated Staphylococcus aureus M: implications for the mechanism of resistance to phagocytosis

1979 • 93 citations

Host-specific evasion of the alternative complement pathway by schistosomes correlates with the presence of a phospholipase C-sensitive surface molecule resembling human decay accelerating factor.

1990 • 91 citations

The lipophosphoglycan of Leishmania

1988 • 87 citations

Epstein-Barr virus regulates activation and processing of the third component of complement.

1988 • 81 citations

Regulation of immune response by components of the complement cascade and their activated fragments

1983 • 78 citations

Role of Escherichia coli K capsular antigens during complement activation, C3 fixation, and opsonization

1979 • 78 citations

Species specificity of recognition by the alternative pathway of complement.

1985 • 74 citations

Strategies of obligate intracellular parasites for evading host defences

1991 • 72 citations

Activation of C3 via the alternative complement pathway results in fixation of C3b to the pneumococcal cell wall.

1980 • 72 citations

Activation of complement by pathogenic and nonpathogenic Entamoeba histolytica.

1986 • 71 citations

Decay-Accelerating Factor and Membrane Cofactor Protein

1990 • 71 citations

Lysis of complement-sensitive Entamoeba histolytica by activated terminal complement components. Initiation of complement activation by an extracellular neutral cysteine proteinase.

1990 • 70 citations

Complement, viruses, and virus-infected cells

1983 • 70 citations

Two variant surface glycoproteins of Trypanosoma Brucei of different sequence classes have similar 6 Å resolution X-ray structures

1987 • 68 citations

Binding and release of C3 from Leishmania donovani promastigotes during incubation in normal human serum.

1989 • 65 citations

The interaction of C3b bound to pneumococci with factor H (beta 1H globulin), factor I (C3b/C4b inactivator), and properdin factor B of the human complement system.

1983 • 64 citations

Inhibition of the alternative pathway of human complement by structural analogues of sialic acid.

1988 • 61 citations

Restriction of the alternative pathway of human complement by intact Trypanosoma brucei subsp. gambiense

1986 • 61 citations

Purification of a Trypanosoma cruzi membrane glycoprotein which elicits lytic antibodies

1989 • 59 citations

Physicochemical Characterization of Complement-Interacting Factors from Taenia taeniaeformis

1978 • 58 citations

Serum-dependent adhesion and cytotoxicity of cells to Litomosoides carinii microfilariae

1976 • 57 citations

Host modification of Sindbis virus sialic acid content influences alternative complement pathway activation and virus clearance.

1981 • 56 citations

Developmentally regulated expression by Trypanosoma cruzi of molecules that accelerate the decay of complement C3 convertases.

1988 • 56 citations

Interaction of complement with serum-sensitive and serum-resistant strains of Pseudomonas aeruginosa

1986 • 55 citations

Leishmania species: Mechanisms of complement activation by five strains of promastigotes

1986 • 54 citations

The human C3b receptor

1983 • 54 citations

Toxoplasma gondii: mechanism of resistance to complement-mediated killing.

1989 • 53 citations

The superfamily of C3b/C4b-binding proteins.

1987 • 53 citations

Susceptibility of Giardia lamblia trophozoites to the lethal effect of human serum.

1984 • 51 citations

Serum dependent cell‐mediated immune reactions to Brugia pahangi infective larvae*

1985 • 51 citations

Differences in uptake of mycobacteria by human monocytes: a role for complement

1988 • 51 citations

Aspergillus fumigatus complement inhibitor: production, characterization, and purification by hydrophobic interaction and thin-layer chromatography

1990 • 50 citations

Complement activation by the surface of Plasmodium falciparum infected erythrocytes

1984 • 47 citations

Eosinophil‐larval‐interaction in onchocerciasis: heterogeneity of in vitro adherence of eosinophils to infective third and fourth stage larvae and microfilariae of Onchocerca volvulus

1991 • 45 citations

The cestocidal effect of complement in normal and immune sera in vitro

1976 • 42 citations

C3b generation is affected by the structure of the O-antigen polysaccharide in lipopolysaccharide from salmonellae.

1987 • 42 citations

Activation of the alternative pathway of complement: efficient fluid‐phase amplification by blockade of the regulatory complement protein β1H through sulfated polyanions

1981 • 40 citations

Babesia rodhaini interactions with complement: relationship to parasitic entry into red cells.

1980 • 37 citations

Activation of the alternative complement pathway by Trichomonas vaginalis

1981 • 34 citations

Resistance of highly pathogenic Naegleria fowleri amoebae to complement-mediated lysis

1989 • 32 citations

Parasites and Complement

1988 • 31 citations

Loss of susceptibility to complement lysis in Entamoeba histolytica HM1 by treatment with human serum.

1986 • 28 citations

Complement and parasitic trematodes

1989 • 28 citations

Lysis of pathogenic and nonpathogenic Entamoeba histolytica by human complement: methodological analysis

1992 • 22 citations

Third Component of Complement, Immunoglobulin Deposition, and Leucocyte Attachment Related to Surface Sulfate on Larval Taenia taeniaeformis

1983 • 21 citations

Activation of the classical and alternative pathways of complement by Treponema pallidum subsp. pallidum and Treponema vincentii

1987 • 17 citations

Complement-mediated killing of Opisthorchis viverrini via activation of the alternative pathway

1986 • 16 citations

Activation of the alternative complement pathway in normal human serum by Loa loa and Brugia malayi infective stage larvae.

1985 • 16 citations

Demonstration of C3b receptor‐like activity and of decay‐accelerating factor‐like activity on rabbit erythrocytes

1986 • 12 citations

Complement does not play a role in promotingBabesia rodhaini infections in Balb/C mice

1982 • 11 citations

Complement and Infectious Diseases

2018 • 9 citations

Complement does not facilitate in vitro invasion of bovine erythrocytes by Babesia bovis

1986 • 9 citations