Decay-Accelerating Factor and Membrane Cofactor Protein

CELL-SURFACE ANCHORING OF PROTEINS VIA GLYCOSYL-PHOSPHATIDYLINOSITOL STRUCTURES

1988 • 1,284 citations

Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes

1988 • 963 citations

Glycosyl-Phosphatidylinositol Moiety That Anchors Trypanosoma brucei Variant Surface Glycoprotein to the Membrane

1988 • 701 citations

Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system.

1982 • 603 citations

Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes.

1984 • 571 citations

Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein

1988 • 447 citations

The Regulators of Complement Activation (RCA) Gene Cluster

1989 • 442 citations

Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor.

1983 • 438 citations

Distribution of decay-accelerating factor in the peripheral blood of normal individuals and patients with paroxysmal nocturnal hemoglobinuria.

1985 • 408 citations

Purification and characterization of a membrane protein (gp45-70) that is a cofactor for cleavage of C3b and C4b.

1986 • 401 citations

The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria

1988 • 387 citations

Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins

1987 • 359 citations

Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PIPLC). Selective modification of a complement regulatory protein.

1986 • 358 citations

Identification of the complement decay-accelerating factor (DAF) on epithelium and glandular cells and in body fluids.

1987 • 340 citations

Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria.

1983 • 324 citations

A Glycophospholipid Tail at the Carboxyl Terminus of the Thy-1 Glycoprotein of Neurons and Thymocytes

1985 • 306 citations

Decay accelerating factor of complement is anchored to cells by a C-terminal glycolipid

1986 • 282 citations

Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement.

1987 • 256 citations

A Glycan-Phosphatidylinositol-Specific Phospholipase D in Human Serum

1987 • 248 citations

Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins.

1988 • 215 citations

Signal for Attachment of a Phospholipid Membrane Anchor in Decay Accelerating Factor

1987 • 210 citations

The mechanism of action of decay-accelerating factor (DAF). DAF inhibits the assembly of C3 convertases by dissociating C2a and Bb.

1987 • 205 citations

Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts.

1986 • 177 citations

Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines.

1985 • 170 citations

Deficiency of the homologous restriction factor in paroxysmal nocturnal hemoglobinuria.

1987 • 167 citations

Functional properties of membrane cofactor protein of complement

1989 • 166 citations

Separation of self from non-self in the complement system

1987 • 159 citations

Deficiency of the Complement Regulatory Protein, Decay-Accelerating Factor, on Membranes of Granulocytes, Monocytes, and Platelets in Paroxysmal Nocturnal Hemoglobinuria

1985 • 153 citations

Identification of human erythrocyte blood group antigens on decay- accelerating factor (DAF) and an erythrocyte phenotype negative for daf

1988 • 146 citations

Surface membrane expression by human blood leukocytes and platelets of decay-accelerating factor, a regulatory protein of the complement system

1985 • 143 citations

Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1.

1988 • 141 citations

A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP.

1988 • 132 citations

Decay-accelerating factor is present on cultured human umbilical vein endothelial cells.

1986 • 129 citations

Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor.

1987 • 128 citations

Membrane cofactor protein of complement is present on human fibroblast, epithelial, and endothelial cells.

1989 • 126 citations

Paroxysmal nocturnal haemoglobinuria

1992 • 117 citations

Amelioration of lytic abnormalities of paroxysmal nocturnal hemoglobinuria with decay-accelerating factor.

1985 • 117 citations

Inhibition of complement by a substance isolated from human erythrocytes — I

1969 • 117 citations

Variant surface glycoproteins of Trypanosoma brucei are synthesised with cleavable hydrophobic sequences at the carboxy and amino termini

1981 • 111 citations

Distribution of membrane cofactor protein of complement on human peripheral blood cells. An altered form is found on granulocytes

1988 • 105 citations

The gene encoding decay-accelerating factor (DAF) is located in the complement-regulatory locus on the long arm of chromosome 1.

1987 • 100 citations

Paroxysmal Nocturnal Haemoglobinuria

1985 • 98 citations

Paroxysmal nocturnal hemoglobinuria

1959 • 96 citations

Inhibition of complement by a substance isolated from human erythrocytes—II

1969 • 92 citations

Biosynthesis and glycosylation of the human complement regulatory protein decay-accelerating factor.

1986 • 87 citations

Human C3b- and C4b-regulatory proteins: a new multi-gene family

1985 • 84 citations

Endogenous association of decay-accelerating factor (DAF) with C4b and C3b on cell membranes.

1986 • 82 citations

Purification from guinea pig erythrocyte stroma of a decay-accelerating factor for the classical c3 convertase, C4b,2a.

1981 • 82 citations

Differences between the binding sites of the complement regulatory proteins DAF, CR1, and factor H on C3 convertases.

1986 • 82 citations

Normal polymorphic variations and transcription of the decay accelerating factor gene in paroxysmal nocturnal hemoglobinuria cells.

1988 • 80 citations

Neutrophil (Leucocyte) Alkaline Phosphatase in Paroxysmal Nocturnal Haemoglobinuria

1965 • 79 citations

A polymorphism of the complement regulatory protein MCP (membrane cofactor protein or gp45-70).

1987 • 74 citations

Decay-accelerating factor. Genetic polymorphism and linkage to the RCA (regulator of complement activation) gene cluster in humans.

1987 • 70 citations

Structural gene for human membrane cofactor protein (MCP) of complement maps to within 100 kb of the 3' end of the C3b/C4b receptor gene.

1989 • 67 citations

p65: A C3b-binding protein on murine cells that shares antigenic determinants with the human C3b receptor (CR1) and is distinct from murine C3b receptor.

1985 • 66 citations

Influence of glycosylation on allelic and cell-specific Mr variation, receptor processing, and ligand binding of the human complement C3b/C4b receptor.

1986 • 62 citations

Identification of a third component of complement-binding glycoprotein of human platelets.

1986 • 57 citations

Glycolipid reanchoring of T-lymphocyte surface antigen CD8 using the 3' end sequence of decay-accelerating factor's mRNA.

1988 • 55 citations

Biochemical characterization of membrane cofactor protein of the complement system.

1988 • 54 citations

Decay-accelerating factor is present on paroxysmal nocturnal hemoglobinuria erythroid progenitors and lost during erythropoiesis in vitro.

1985 • 53 citations

Isolation of a biologically active macrophage receptor for the third component of complement

1981 • 43 citations

Natural killer cells are deficient in the surface expression of the complement regulatory protein, decay accelerating factor (DAF).

1986 • 40 citations

Additional forms of human decay-accelerating factor (DAF).

1987 • 35 citations

Identification of a C3b/iC3 binding protein of rabbit platelets and leukocytes. A CR1-like candidate for the immune adherence receptor.

1988 • 29 citations

A high m.w. form of decay-accelerating factor (DAF-2) exhibits size abnormalities in paroxysmal nocturnal hemoglobinuria erythrocytes.

1987 • 24 citations

Isolation of decay-accelerating factor (DAF) from rabbit erythrocyte membranes

1987 • 19 citations

Ligand binding specificity of a rabbit alveolar macrophage receptor for C3b.

1982 • 18 citations

Demonstration of C3b receptor‐like activity and of decay‐accelerating factor‐like activity on rabbit erythrocytes

1986 • 12 citations