Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [³H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

Olefin homologation with titanium methylene compounds

1978 • 1,024 citations

The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors

1987 • 303 citations

Transition metal catalyzed reactions of organozinc reagents

1992 • 289 citations

Stereospecific binding of the antidepressant rolipram to brain protein structures

1986 • 235 citations

The anti‐emetic effects of CP‐99,994 in the ferret and the dog: role of the NK₁ receptor

1995 • 212 citations

Results of a Phase II Study of the Antidepressant Effect of Rolipram

1984 • 175 citations

Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.

1992 • 139 citations

Expression and regulation of human and rat phosphodiesterase type IV isogenes

1994 • 139 citations

Excitation of area postrema neurons by transmitters, peptides, and cyclic nucleotides

1988 • 134 citations

Inhibitors of Cyclic Nucleotide Phosphodiesterase Isoenzymes—their Potential Utility in the Therapy of Asthma

1994 • 134 citations

Antioxidant activity of probucol and its analogs in hypercholesterolemic Watanabe rabbits

1991 • 116 citations

Chemistry of oxasilacyclopropane. 2. Formations of dioxasilacyclopentanes in the reaction of oxasilacyclopropane derivatives with adamantanone and norbornone

1978 • 86 citations

Close correlation between behavioural response and binding in vivo for inhibitors of the rolipram-sensitive phosphodiesterase

1990 • 66 citations

Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl-2-imidazolidinones

1991 • 48 citations