Inhibition of Neutrophil Apoptosis by Type 1 IFN Depends on Cross-Talk Between Phosphoinositol 3-Kinase, Protein Kinase C-δ, and NF-κB Signaling Pathways

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

The extended protein kinase C superfamily

1998 • 1,544 citations

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

1989 • 1,540 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

JC‐1, but not DiOC₆(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis

1997 • 982 citations

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways

1999 • 785 citations

Type I Interferons Keep Activated T Cells Alive

1999 • 769 citations

Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators

1993 • 726 citations

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1995 • 684 citations

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

2001 • 617 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death

1992 • 367 citations

Activation of IκB Kinase β by Protein Kinase C Isoforms

1999 • 366 citations

The Antiapoptotic Gene mcl-1 Is Up-Regulated by the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing CREB

1999 • 358 citations

Mcl-1 Expression in Human Neutrophils: Regulation by Cytokines and Correlation With Cell Survival

1998 • 349 citations

Ceramide Induces Bcl2 Dephosphorylation via a Mechanism Involving Mitochondrial PP2A

1999 • 340 citations

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosis in Vitro

1999 • 329 citations

Seeing the wood for the trees: the forgotten role of neutrophils in rheumatoid arthritis

1997 • 327 citations

Activation of the NF-κB Pathway by Inflammatory Stimuli in Human Neutrophils

1997 • 321 citations

Differential expression of bcl-2 and susceptibility to anti-Fas- mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils

1994 • 320 citations

STAT3 as an Adapter to Couple Phosphatidylinositol 3-Kinase to the IFNAR1 Chain of the Type I Interferon Receptor

1997 • 263 citations

Regulation of Phospholipid Scramblase Activity during Apoptosis and Cell Activation by Protein Kinase Cδ

2000 • 242 citations

PKC-δ is an apoptotic lamin kinase

2000 • 220 citations

BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis

2001 • 220 citations

Protein Kinase C-δ (PKC-δ) Is Activated by Type I Interferons and Mediates Phosphorylation of Stat1 on Serine 727

2002 • 212 citations

Inactivation of DNA-Dependent Protein Kinase by Protein Kinase Cδ: Implications for Apoptosis

1998 • 211 citations

The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis

1994 • 210 citations

Interferon‐β mediates stromal cell rescue of T cells from apoptosis

1999 • 194 citations

Spontaneous Neutrophil Apoptosis Involves Caspase 3-mediated Activation of Protein Kinase C-δ

1999 • 186 citations

Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets

1999 • 168 citations

Interferon-β mediates stromal cell rescue of T cells from apoptosis

1999 • 158 citations

The IL-1 beta-converting enzyme (caspase-1) inhibits apoptosis of inflammatory neutrophils through activation of IL-1 beta.

1998 • 157 citations

IFNα/β promotes cell survival by activating NF-κB

2000 • 155 citations

Activation of protein kinase C δ by the c-Abl tyrosine kinase in response to ionizing radiation

1998 • 148 citations

Direct Association of STAT3 with the IFNAR-1 Chain of the Human Type I Interferon Receptor

1996 • 134 citations

The induction by human interleukin-6 of apoptosis in the promonocytic cell line U937 and human neutrophils.

1992 • 131 citations

The IL-1β-Converting Enzyme (Caspase-1) Inhibits Apoptosis of Inflammatory Neutrophils Through Activation of IL-1β

1998 • 121 citations

Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis.

1997 • 104 citations

Inhibition of T cell apoptosis by IFN-β rapidly reverses nuclear translocation of protein kinase C-δ

1999 • 101 citations

Cytokine-Induced Protein Kinase B Activation and Bad Phosphorylation Do Not Correlate with Cell Survival of Hemopoietic Cells

1999 • 91 citations

A role for PKC-δ and PI 3-kinase in TNF-α-mediated antiapoptotic signaling in the human neutrophil

2002 • 86 citations

Bcl-Xshort is elevated following severe global ischemia in rat brains

1997 • 83 citations

Temperature-dependent Arrest of Neutrophil Apoptosis

2000 • 74 citations

Interferon-Dependent Activation of the Serine Kinase PI 3′-Kinase Requires Engagement of the IRS Pathway but Not the Stat Pathway

2000 • 70 citations

Signal Transduction by Type I Interferons

2002 • 53 citations

The function and fate of neutrophils at the inflamed site: prospects for therapeutic intervention.

2000 • 49 citations

Atypical λ/ιPKC Conveys 5-Lipoxygenase/Leukotriene B4-mediated Cross-talk between Phospholipase A2s Regulating NF-κB Activation in Response to Tumor Necrosis Factor-α and Interleukin-1β

2001 • 44 citations

Cytokine-mediated inhibition of apoptosis in non-transformed T cells and neutrophils can be dissociated from protein kinase B activation

2002 • 44 citations

Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death

1992 • 43 citations

Interferon β Affects Retinal Pigment Epithelial Cell Proliferation via Protein Kinase C Pathways

2001 • 10 citations