The Lymphopenic Mouse in Immunology: From Patron to Pariah

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

The carrier effect in the secondary response to hapten‐protein conjugates. II. Cellular cooperation

1971 • 677 citations

Thymus-Marrow Cell Combinations. Synergism in Antibody Production.

1966 • 613 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

Population Biology of Lymphocytes: The Flight for Survival

2000 • 439 citations

Homeostatic proliferation is a barrier to transplantation tolerance

2003 • 403 citations

Naïve and Memory CD4 ⁺ T Cell Survival Controlled by Clonal Abundance

2006 • 348 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

Interleukin 15 Controls both Proliferation and Survival of a Subset of Memory-Phenotype CD8+ T Cells

2002 • 332 citations

STUDIES ON THE IMMUNOLOGICAL RESPONSE TO FOREIGN TUMOR TRANSPLANTS IN THE MOUSE

1955 • 317 citations

Neonates Support Lymphopenia-Induced Proliferation

2003 • 291 citations

Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion

2005 • 243 citations

Regulation of mature T cell homeostasis

2005 • 191 citations

The molecular program induced in T cells undergoing homeostatic proliferation

2004 • 176 citations

The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells.

1987 • 173 citations

IL-2 Secretion by CD4+ T Cells In Vivo Is Rapid, Transient, and Influenced by TCR-Specific Competition

2004 • 166 citations

Two Distinct Stages in the Transition from Naive CD4 T Cells to Effectors, Early Antigen-Dependent and Late Cytokine-Driven Expansion and Differentiation

2000 • 161 citations

Survival and Homeostatic Proliferation of Naive Peripheral CD4+ T Cells in the Absence of Self Peptide:MHC Complexes

2000 • 156 citations

CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling

2000 • 156 citations

Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes

2002 • 144 citations

Adaptive Tolerance of CD4+ T Cells In Vivo: Multiple Thresholds in Response to a Constant Level of Antigen Presentation

2001 • 124 citations

Ionizing radiation and autoimmunity. Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells.

1994 • 101 citations

Epitope-Specific Regulation

1983 • 99 citations

Cell division in the compartment of naive and memory T lymphocytes

1996 • 84 citations

Are Major Histocompatibility Complex Molecules Involved in the Survival of Naive CD4+ T Cells?

2003 • 76 citations

Survival signaling in resting B cells

2004 • 63 citations

STUDIES ON THE TRANSFER OF LYMPH NODE CELLS

1954 • 56 citations

Adoptive transfer of immune reactions by cells

1957 • 44 citations

The Impact of T Cell Intrinsic Antigen Adaptation on Peripheral Immune Tolerance

2006 • 28 citations

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