Transgenic Expression of Helios in B Lineage Cells Alters B Cell Properties and Promotes Lymphomagenesis

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

T Cell-Independent Antigens Type 2

1995 • 798 citations

Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

1997 • 792 citations

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

1996 • 619 citations

Thymopoiesis independent of common lymphoid progenitors

2003 • 548 citations

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

1995 • 530 citations

Transcriptional Control of Early B Cell Development

2004 • 479 citations

Ikaros, an Early Lymphoid-Specific Transcription Factor and a Putative Mediator for T Cell Commitment

1992 • 458 citations

Subclass Restriction of Murine Anti-Carbohydrate Antibodies

1978 • 428 citations

The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins.

1994 • 424 citations

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development.

1996 • 379 citations

Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

1992 • 376 citations

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

1997 • 360 citations

Haematopoietic cell-fate decisions, chromatin regulation and ikaros

2002 • 324 citations

Aiolos Regulates B Cell Activation and Maturation to Effector State

1998 • 313 citations

Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin

1998 • 244 citations

The Chromatin Remodeler Mi-2β Is Required for CD4 Expression and T Cell Development

2004 • 239 citations

Pax5 Promotes B Lymphopoiesis and Blocks T Cell Development by Repressing Notch1

2002 • 239 citations

Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors

1998 • 228 citations

The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene.

1994 • 225 citations

Cell-Autonomous Defects in Dendritic Cell Populations of Ikaros Mutant Mice Point to a Developmental Relationship with the Lymphoid Lineage

1997 • 221 citations

Ikaros Sets Thresholds for T Cell Activation and Regulates Chromosome Propagation

1999 • 176 citations

Transcription Factors in Lymphocyte Development— T and B Cells Get Together

1999 • 169 citations

E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.

1993 • 162 citations

Ikaros is critical for B cell differentiation and function

2002 • 160 citations

Control of lymphocyte development by the Ikaros gene family

1999 • 157 citations

Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros

1999 • 157 citations

Widespread Failure of Hematolymphoid Differentiation Caused by a Recessive Niche-Filling Allele of the Ikaros Transcription Factor

2003 • 152 citations

Down-regulation of TDT transcription in CD4⁺CD8⁺thymocytes by Ikaros proteins in direct competition with an Ets activator

2001 • 151 citations

The CD8α Gene Locus Is Regulated by the Ikaros Family of Proteins

2002 • 149 citations

Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation

2001 • 148 citations

Abnormalities of the Immune System Induced by Dysregulated bcl-2 Expression in Transgenic Mice

1990 • 129 citations

B Lineage–specific Regulation of V(D)J Recombinase Activity Is Established in Common Lymphoid Progenitors

2004 • 127 citations

Selective Dimerization of a C2H2 Zinc Finger Subfamily

2003 • 126 citations

T-independent type 2 antigens induce B cell proliferation in multiple splenic sites, but exponential growth is confined to extrafollicular foci

1999 • 122 citations

Eos and Pegasus, Two Members of the Ikaros Family of Proteins with Distinct DNA Binding Activities

2000 • 121 citations

Frequent Aberrant Immunoglobulin Gene Rearrangements in Pro-B Cells Revealed by a bcl-x Transgene

1996 • 120 citations

Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage

2003 • 82 citations

Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system

1999 • 63 citations

Pax5 determines B- versus T-cell fate and does not block early myeloid-lineage development

2003 • 62 citations

The establishment and maintenance of lymphocyte identity through gene silencing

2003 • 60 citations

The Lymphoid Transcription Factor LyF-1 Is Encoded by Specific, Alternatively Spliced mRNAs Derived from the Ikaros Gene

1994 • 54 citations

Transcription factor regulation of B lineage commitment

2001 • 51 citations

Expression of the Ikaros gene family in childhood acute lymphoblastic leukaemia

2002 • 39 citations

Transcription factors controlling the beginning and end of B-cell differentiation

2003 • 22 citations

The C-terminal Domain of Eos Forms a High Order Complex in Solution

2003 • 14 citations