Future Research Directions in Acute Lung Injury

Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome

2000 • 11,795 citations

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

2001 • 8,356 citations

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

2001 • 5,900 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

The Acute Respiratory Distress Syndrome

1996 • 5,031 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

The Acute Respiratory Distress Syndrome

2000 • 4,409 citations

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

2000 • 3,789 citations

Use of proteomic patterns in serum to identify ovarian cancer

2002 • 3,227 citations

Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell

2001 • 2,653 citations

Genes Expressed in Human Tumor Endothelium

2000 • 1,838 citations

Effect of Mechanical Ventilation on Inflammatory Mediators in Patients With Acute Respiratory Distress Syndrome

1999 • 1,816 citations

Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model.

1997 • 1,327 citations

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

2002 • 1,090 citations

TREM-1 amplifies inflammation and is a crucial mediator of septic shock

2001 • 1,035 citations

Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice.

1995 • 922 citations

Widespread Coronary Inflammation in Unstable Angina

2002 • 911 citations

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

2002 • 897 citations

Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis

1995 • 886 citations

Mutation of the Stargardt Disease Gene ( ABCR ) in Age-Related Macular Degeneration

1997 • 861 citations

Multiple System Organ Failure

1998 • 827 citations

Pulmonary Dead-Space Fraction as a Risk Factor for Death in the Acute Respiratory Distress Syndrome

2002 • 806 citations

Incidence, Risk Factors, and Outcome of Severe Sepsis and Septic Shock in Adults

1995 • 699 citations

Activated platelets mediate inflammatory signaling by regulated interleukin 1β synthesis

2001 • 671 citations

Biological markers of acute lung injury: prognostic and pathogenetic significance.

1997 • 599 citations

Incidence and Mortality after Acute Respiratory Failure and Acute Respiratory Distress Syndrome in Sweden, Denmark, and Iceland

1999 • 586 citations

Bone marrow-derived cells as progenitors of lung alveolar epithelium

2001 • 555 citations

Cytokine Balance in the Lungs of Patients with Acute Respiratory Distress Syndrome

2001 • 541 citations

Normal Responses to Injury Prevent Systemic Inflammation and Can Be Immunosuppressive

2001 • 514 citations

Pharmacological Stimulation of the Cholinergic Antiinflammatory Pathway

2002 • 507 citations

Expression Profiling in the Muscular Dystrophies

2000 • 484 citations

Reduced Quality of Life in Survivors of Acute Respiratory Distress Syndrome Compared With Critically Ill Control Patients

1999 • 431 citations

Dissecting Human Disease in the Postgenomic Era

2001 • 423 citations

Angiotensin Converting Enzyme Insertion/Deletion Polymorphism Is Associated with Susceptibility and Outcome in Acute Respiratory Distress Syndrome

2002 • 411 citations

PULMONARY PATHOLOGY OF ACUTE RESPIRATORY DISTRESS SYNDROME

2000 • 407 citations

Translation control: bridging the gap between genomics and proteomics?

2001 • 382 citations

The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis

2002 • 353 citations

Biomechanical activation: an emerging paradigm in endothelial adhesion biology.

1997 • 348 citations

High lung volume increases stress failure in pulmonary capillaries

1992 • 320 citations

Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia

1999 • 314 citations

Perspective on Lung Injury and Recruitment

2002 • 310 citations

Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair

2002 • 304 citations

Mass spectrometry and proteomics

2000 • 294 citations

Regulation of blood coagulation

2000 • 284 citations

Inhibition of Intestinal Epithelial Apoptosis and Survival in a Murine Model of Pneumonia-Induced Sepsis

2002 • 282 citations

Platelet GPIIb/IIIa antagonists: the first anti-integrin receptor therapeutics.

1997 • 273 citations

Rat genetics: attachign physiology and pharmacology to the genome

2002 • 271 citations

Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets

1998 • 269 citations

Mechanisms of Leukocyte Sequestration in Inflamed Lungs

2001 • 267 citations

Role of Coagulation Inhibitors in Inflammation

2001 • 261 citations

The effects of mechanical forces on lung functions

2000 • 199 citations

Polymorphisms of human SP‐A, SP‐B, and SP‐D genes: association of SP‐B Thr131Ile with ARDS

2000 • 195 citations

Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation

2001 • 187 citations

Adhesion and signaling in vascular cell--cell interactions.

1996 • 183 citations

Molecular Signatures of Sepsis

2001 • 183 citations

Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate*

2002 • 177 citations

Coagulation Blockade Prevents Sepsis-induced Respiratory and Renal Failure in Baboons

2001 • 165 citations

Acute Lung Injury

2002 • 165 citations

Pulmonary Edema Fluid from Patients with Acute Lung Injury Augments In Vitro Alveolar Epithelial Repair by an IL-1 β -dependent Mechanism

2001 • 164 citations

Pressure is proinflammatory in lung venular capillaries

1999 • 145 citations

Toll-like receptors: how they work and what they do

2002 • 138 citations

TNF-α Compensates for the Impaired Host Defense of IL-1 Type I Receptor-Deficient Mice During Pneumococcal Pneumonia

2001 • 125 citations

DNA microarrays and beyond: completing the journey from tissue to cell

2001 • 124 citations

Regulation of Toll-Like Receptor 4 Expression in the Lung Following Hemorrhagic Shock and Lipopolysaccharide

2002 • 112 citations

Ventilator-induced lung injury: in vivo and in vitro mechanisms

2002 • 107 citations

Genetic Polymorphisms Associated With Susceptibility and Outcome in ARDS

2002 • 89 citations

Cell adhesion regulates gene expression at translational checkpoints in human myeloid leukocytes

2001 • 76 citations

Interactions between CBP, NF-κB, and CREB in the lungs after hemorrhage and endotoxemia

2001 • 69 citations

Priming for Enhanced Alveolar Fibrin Deposition after Hemorrhagic Shock

2000 • 68 citations

Anticoagulants for Acute Respiratory Distress Syndrome

2001 • 65 citations

Mechanisms of Leukocyte Sequestration in Inflamed Lungs

2001 • 56 citations

The era of genomics: Impact on sepsis clinical trial design

2002 • 46 citations

Perspectives for vascular genomics

2000 • 45 citations

MEDIATORS AND MECHANISMS OF ACUTE LUNG INJURY

2000 • 38 citations

Bacterial Priming Increases Lung Injury in Gram-negative Sepsis

1998 • 33 citations

Functional Genomics and Expression Profiling

2000 • 30 citations

Microarrays in hematology

2002 • 23 citations

Critical Care Medicine in AJRCCM 2001

2002 • 2 citations