Coagulation Blockade Prevents Sepsis-induced Respiratory and Renal Failure in Baboons

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

2001 • 5,900 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

1987 • 836 citations

Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways

1990 • 796 citations

Inflammatory Cytokines in the BAL of Patients With ARDS

1995 • 667 citations

Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa

2000 • 663 citations

Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways

1990 • 611 citations

STRUCTURAL ALTERATIONS OF LUNG PARENCHYMA IN THE ADULT RESPIRATORY DISTRESS SYNDROME

1982 • 584 citations

Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock.

1993 • 552 citations

Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

1997 • 472 citations

Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody.

1991 • 428 citations

Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees.

1994 • 405 citations

Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees.

1994 • 387 citations

Alteration of surfactant function due to protein leakage: special interaction with fibrin monomer

1985 • 374 citations

Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor

1999 • 316 citations

Effect of Human Recombinant Interleukin-6 and Interleukin-8 on Monocyte Procoagulant Activity

1997 • 288 citations

Early Detection of Type III Procollagen Peptide in Acute Lung Injury

1997 • 258 citations

Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia

2000 • 255 citations

DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage

1991 • 216 citations

Potential Mechanisms for a Proinflammatory Vascular Cytokine Response to Coagulation Activation

1998 • 213 citations

Low levels of tissue factor are compatible with development and hemostasis in mice.

1998 • 204 citations

The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation

2000 • 197 citations

Tissue Factor and Factor VIIa Receptor/Ligand Interactions Induce Proinflammatory Effects in Macrophages

1999 • 178 citations

Binding of Factor VIIa to Tissue Factor on Keratinocytes Induces Gene Expression

2000 • 177 citations

Active Site Inhibited Factor VIIa (DEGR VIIa) Attenuates the Coagulant and Interleukin-6 and -8, but not Tumor Necrosis Factor, Responses of the Baboon to LD100Escherichia coli

1998 • 175 citations

Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli

2000 • 172 citations

Macrophage migration in fibrin gel matrices.

1986 • 160 citations

The protein C pathway

2000 • 159 citations

Signal Transduction via the Mitogen-activated Protein Kinase Pathway Induced by Binding of Coagulation Factor VIIa to Tissue Factor

1998 • 151 citations

Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees

1994 • 150 citations

Antithrombin-III prevents the lethal effects of Escherichia coli infusion in baboons.

1988 • 142 citations

Serial abnormalities of fibrin turnover in evolving adult respiratory distress syndrome

1991 • 133 citations

Incorporation of an Active Site Inhibitor in Factor VIIa Alters the Affinity for Tissue Factor

1997 • 132 citations

Complete Inhibition of Endotoxin-Induced Coagulation Activation in Chimpanzees with a Monoclonal Fab Fragment against Factor VII/VIIa

1995 • 128 citations

Tissue Factor-Dependent Vascular Endothelial Growth Factor Production by Human Fibroblasts in Response to Activated Factor VII

1998 • 125 citations

Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees

1994 • 108 citations

Clinical trial results with antithrombin III in sepsis

2000 • 85 citations

Extravascular coagulation and fibrin deposition in acute lung injury.

1994 • 80 citations

Local abnormalities of coagulation and fibrinolytic pathways that promote alveolar fibrin deposition in the lungs of baboons with diffuse alveolar damage.

1989 • 79 citations

Pulmonary and Oxygen Transport Effects of Intravenously Administered Endotoxin in Normal Humans

1992 • 62 citations

Antibody to E- and L-Selectin Does Not Prevent Lung Injury or Mortality in Septic Baboons

1998 • 55 citations

Differential Effects of Anti-cytokine Treatment on Bronchoalveolar Hemostasis in Endotoxemic Chimpanzees

1998 • 47 citations

Glomerular tissue factor expression in crescentic glomerulonephritis. Correlations between antigen, activity, and mRNA.

1995 • 47 citations

Protease‐activated receptors and their role in IL‐6 and NF‐IL‐6 expression in human gingival fibroblasts

1998 • 46 citations

Cell surface fibrinogen-fibrin receptors on cultured human fibroblasts. Association with fibronectin (cold insoluble globulin, LETS protein) and loss in SV40 transformed cells.

1979 • 45 citations

Tissue factor in bronchoalveolar lavage fluids. Evidence for an alveolar macrophage source.

1985 • 43 citations

Bacterial Priming Increases Lung Injury in Gram-negative Sepsis

1998 • 33 citations

Antibody to Intercellular Adhesion Molecule 1 (CD54) Decreases Survival and Not Lung Injury in Baboons with Sepsis

2001 • 25 citations

Endothelin 1 and Thrombin Synergistically Stimulate IL-6 mRNA Expression and Protein Production in Human Umbilical Vein Endothelial Cells

1995 • 23 citations

PROINFLAMMATORY CYTOKINES INCREASE IN SEPSIS AFTER ANTI-ADHESION MOLECULE THERAPY

2000 • 12 citations

Coagulation inhibitor replacement during sepsis: Useless?

2000 • 11 citations

Effect of locally-applied active site-blocked activated factor VII (ASIS) on experimental arterial thrombosis

2000 • 10 citations

Deleted Work

1955 • 0 citations