Systemic approaches to modifying quinolinic acid striatal lesions in rats

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Calcium Dependence of Toxic Cell Death: A Final Common Pathway

1979 • 1,478 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1986 • 1,283 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

1983 • 1,247 citations

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

1976 • 832 citations

Anticonvulsant Action of Excitatory Amino Acid Antagonists

1982 • 692 citations

The neurotoxicity of excitatory amino acids is produced by passive chloride influx

1985 • 634 citations

The role of specific ions in glutamate neurotoxicity

1986 • 298 citations

Neurons Containing NADPH-Diaphorase Are Selectively Resistant to Quinolinate Toxicity

1986 • 292 citations

The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro

1987 • 268 citations

EXCITATORY AMINOACID ANTAGONISTS PROVIDE A THERAPEUTIC APPROACH TO NEUROLOGICAL DISORDERS

1985 • 217 citations

Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: Dependence on calcium concentration

1986 • 204 citations

BACLOFEN: EFFECTS ON AMINO ACID RELEASE AND METABOLISM IN SLICES OF GUINEA PIG CEREBRAL CORTEX

1979 • 180 citations

The interaction between MK-801 and receptors for : Functional consequences

1987 • 149 citations

The anti-excitotoxic effects of certain anesthetics, analgesics and sedative-hypnotics

1986 • 147 citations

No evidence for preservation of somatostatin-containing neurons after intrastriatal injections of quinolinic acid

1987 • 126 citations

A role for taurine in the maintenance of homeostasis in the central nervous system during hyperexcitation?

1984 • 119 citations

On the pharmacology of the ketamine enantiomorphs in the rat.

1977 • 118 citations

Influence of vitamin E and selenium on glutathione-dependent protection against microsomal lipid peroxidation

1984 • 112 citations

Substance P‐like immunoreactivity is reduced in Alzheimer's disease cerebral cortex

1987 • 86 citations

A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats

1987 • 76 citations

Cytoplasmic calcium elevation in hippocampal granule cell induced by perforant path stimulation andl-glutamate application

1987 • 75 citations

Calcium influx accompanies but does not cause excitotoxin-induced neuronal necrosis in retina

1985 • 74 citations

N-methylaspartate-activated calcium channels in rat brain cortex slices. Effect of calcium channel blockers and of inhibitory and depressant substances

1986 • 64 citations

The novel anticonvulsant MK-801 interacts with central phencyclidine recognition sites in rat brain

1987 • 63 citations

An examination of neuropeptide Y postmortem stability in an animal model simulating human autopsy conditions

1986 • 54 citations

Excitotoxin lesions do not mimic the alteration of somatostatin in Huntington's disease

1985 • 35 citations

Uptake of a novel anticonvulsant compound, 2-amino-7-phosphono-[4,5-3H]Heptanoic acid, into mouse brain

1983 • 35 citations

Nimodipine levels in gerbil brain following parenteral drug administration

1985 • 30 citations

Effects of ketamine on the in vivo toxicity of quinolinate and in the rat hippocampus

1987 • 25 citations

Chronic taurine effects on various neurochemical indices in control and kainic acid-lesioned neostriatum

1979 • 22 citations

Reduction of brain taurine: Effects on neurotoxic and metabolic actions of kainate

1987 • 22 citations

Huntington’s Disease: Anti-Neurotoxic Therapeutic Strategies

1983 • 18 citations

Pharmacological protection against the toxicity of N-methyl-d-aspartate in immature rat cerebellar slices

1987 • 18 citations

Ethanol, baclofen, and kainic acid neurotoxicity

1980 • 17 citations

Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.

1986 • 16 citations

Baclofen attenuates hyperpolarizing not depolarizing responses of caudate neurons in cat

1985 • 13 citations

Huntington’s Disease: Anti-Neurotoxic Therapeutic Strategies

1983 • 2 citations