Phosphatidylinositol 3′-Kinase and SH2-Containing Inositol Phosphatase (SHIP) Are Recruited by Distinct Positive and Negative Growth-Regulatory Domains in the Granulocyte Colony-Stimulating Factor Receptor

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

1996 • 770 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

Mutations in the Gene for the Granulocyte Colony-Stimulating–Factor Receptor in Patients with Acute Myeloid Leukemia Preceded by Severe Congenital Neutropenia

1995 • 471 citations

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.

1996 • 429 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

Three different mRNAs encoding human granulocyte colony-stimulating factor receptor.

1990 • 304 citations

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.

1991 • 297 citations

Molecular analysis of the granulocyte colony-stimulating factor receptor

1996 • 291 citations

STAT3 as an Adapter to Couple Phosphatidylinositol 3-Kinase to the IFNAR1 Chain of the Type I Interferon Receptor

1997 • 263 citations

Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation.

1993 • 246 citations

Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor

1994 • 240 citations

Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by activating a Ptdlns(4,5)P2 3-OH kinase

1992 • 240 citations

Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.

1994 • 220 citations

Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains.

1990 • 213 citations

Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.

1994 • 209 citations

Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

1993 • 203 citations

The Emerging Field of Receptor-Mediated Inhibitory Signaling: SHP or SHIP?

1996 • 174 citations

Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP.

1996 • 173 citations

Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK

1995 • 162 citations

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines

1995 • 160 citations

Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3-Kinase and for EpR-associated PI 3-Kinase Activity

1995 • 146 citations

The Src Homology 2 (SH2) Domain of SH2-containing Inositol Phosphatase (SHIP) Is Essential for Tyrosine Phosphorylation of SHIP, Its Association with Shc, and Its Induction of Apoptosis

1997 • 133 citations

Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate.

1991 • 123 citations

Recruitment and Phosphorylation of SH2-Containing Inositol Phosphatase and Shc to the B-Cell Fcϒ Immunoreceptor Tyrosine-Based Inhibition Motif Peptide Motif

1997 • 122 citations

Phosphoinositide 3-Kinase and p72 Noncovalently Associate with the Low Affinity Fcγ Receptor on Human Platelets through an Immunoreceptor Tyrosine-based Activation Motif

1996 • 111 citations

A point mutation in the granulocyte colony-stimulating factor receptor (G-CSF-R) gene in a case of acute myeloid leukemia results in the overexpression of a novel G-CSF-R isoform

1995 • 104 citations

Phosphoinositide 3-kinase activation and platelet function

1996 • 103 citations

Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK

1997 • 97 citations

Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor.

1991 • 97 citations

Negative signaling in B cells causes reduced Ras activity by reducing Shc-Grb2 interactions.

1997 • 94 citations

IL-4 Function Can Be Transferred to the IL-2 Receptor by Tyrosine Containing Sequences Found in the IL-4 Receptor α Chain

1996 • 90 citations

Specific involvement of tyrosine 764 of human granulocyte colony- stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes

1996 • 81 citations

The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor.

1993 • 63 citations

Role of the vav Proto-oncogene Product (Vav) in Erythropoietin-mediated Cell Proliferation and Phosphatidylinositol 3-Kinase Activity

1997 • 55 citations

Molecular analysis of the granulocyte colony-stimulating factor receptor

1996 • 50 citations

Point mutations in the conserved box 1 region inactivate the human granulocyte colony-stimulating factor receptor for growth signal transduction and tyrosine phosphorylation of p75c-rel

1995 • 41 citations

Dissociation of the Jak kinase pathway from G-CSF receptor signaling in neutrophils.

1997 • 36 citations

Modulation of apoptosis in human myeloid leukemic cells by GM-CSF.

1995 • 28 citations

Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor

1994 • 27 citations

A Novel Phosphatidylinositol-3,4,5-trisphosphate 5-Phosphatase Associates with the Interleukin-3 Receptor

1996 • 21 citations

Abnormal response to granulocyte colony-stimulating factor (G-CSF) in canine cyclic hematopoiesis is not caused by altered G-CSF receptor expression

1994 • 19 citations

Alternative forms of the human G-CSF receptor function in growth signal transduction.

1991 • 17 citations

Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

1993 • 16 citations

Tyrosine Phosphorylation of vav Protooncogene Product in Primary Human Myelogenous Leukemic Cells Stimulated by Granulocyte Colony-Stimulating Factor

1995 • 12 citations

Specific involvement of tyrosine 764 of human granulocyte colony- stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes

1996 • 9 citations

Abnormal response to granulocyte colony-stimulating factor (G-CSF) in canine cyclic hematopoiesis is not caused by altered G-CSF receptor expression

1994 • 2 citations