The Src Homology 2 (SH2) Domain of SH2-containing Inositol Phosphatase (SHIP) Is Essential for Tyrosine Phosphorylation of SHIP, Its Association with Shc, and Its Induction of Apoptosis

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

A rapid and simple method for the isolation of apoptotic DNA fragments

1994 • 660 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

1993 • 516 citations

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.

1996 • 429 citations

Structure, function, and activation of the erythropoietin receptor

1993 • 360 citations

Interaction of Shc with the ζ Chain of the T Cell Receptor Upon T Cell Activation

1993 • 343 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

1995 • 311 citations

Identification of a specific lns(l,3,4,5)P4-binding protein as a member of the GAP1 family

1995 • 294 citations

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.

1995 • 253 citations

The PTB domain: a new protein module implicated in signal transduction

1995 • 249 citations

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

1996 • 223 citations

Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

1993 • 203 citations

Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc.

1994 • 187 citations

The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif

1995 • 175 citations

c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3.

1993 • 170 citations

Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines

1992 • 128 citations

Properties of Type II Inositol Polyphosphate 5-Phosphatase

1995 • 127 citations

Shc, Grb2, Sosl, and a 150-Kilodalton Tyrosine-Phosphorylated Protein Form Complexes with Fms in Hematopoietic Cells

1994 • 119 citations

Activation of src-related tyrosine kinases by IL-3.

1995 • 77 citations

Interactions in the Fourth Dimension

1992 • 52 citations

Interleukin-3 down-regulates its own receptor

1989 • 40 citations