Macrophages express osteopontin during repair of myocardial necrosis.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3

1985 • 1,605 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Osteopontin--a possible anchor of osteoclasts to bone.

1990 • 816 citations

Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques.

1993 • 642 citations

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

1992 • 605 citations

The Nature and Significance of Osteopontin

1989 • 561 citations

Isolation and characterization of two sialoproteins present only in bone calcified matrix

1985 • 557 citations

Cell proliferation in human coronary arteries.

1990 • 532 citations

Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization

1988 • 519 citations

Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression.

1990 • 467 citations

Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces.

1992 • 459 citations

PDGF ligand and receptor gene expression during repair of arterial injury.

1990 • 431 citations

Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily.

1992 • 394 citations

Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts.

1991 • 387 citations

cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN)

1990 • 361 citations

Proliferation in primary and restenotic coronary atherectomy tissue. Implications for antiproliferative therapy.

1993 • 361 citations

Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection.

1989 • 319 citations

Tissue specificity and developmental expression of rat osteopontin

1987 • 317 citations

Expression of osteopontin messenger RNA by macrophages in atherosclerotic plaques. A possible association with calcification.

1993 • 259 citations

Rat carotid neointimal smooth muscle cells reexpress a developmentally regulated mRNA phenotype during repair of arterial injury.

1992 • 256 citations

Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis

1989 • 238 citations

Transforming Growth Factor Beta-1 in Acute Myocardial Infarction in Rats

1988 • 232 citations

Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis

1994 • 228 citations

Definition of a specific interaction between the early T lymphocyte activation 1 (Eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo.

1990 • 228 citations

Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor.

1988 • 206 citations

Molecular cloning and characterization of 2B7, a rat mRNA which distinguishes smooth muscle cell phenotypes and is identical to osteopontin (secreted phosphoprotein I, 2aR)

1991 • 191 citations

1,25-Dihydroxyvitamin D3 Regulates the Biosynthesis of Osteopontin, a Bone-Derived Cell Attachment Protein, in Clonal Osteoblast-Like Osteosarcoma Cells

1987 • 187 citations

RGD-directed attachment of isolated rat osteoclasts to osteopontin, bone sialoprotein, and fibronectin

1992 • 177 citations

Opposing Effects of Fibroblast Growth Factor and Pertussis Toxin on Alkaline Phosphatase, Osteopontin, Osteocalcin, and Type I Collagen mRNA Levels in ROS 17/2.8 Cells

1989 • 169 citations

Pattern of gene expression following rat tibial marrow ablation

1993 • 155 citations

Osteopontin overexpression is associated with arterial smooth muscle cell proliferation in vitro.

1993 • 135 citations

Transcriptional regulation of osteopontin production in rat osteoblast-like cells by parathyroid hormone.

1989 • 130 citations

The mouse osteopontin gene. Expression in monocytic lineages and complete nucleotide sequence.

1990 • 125 citations

The calcium oxalate crystal growth inhibitor protein produced by mouse kidney cortical cells in culture is osteopontin

1992 • 123 citations

Secreted phosphoprotein mrna is induced during multi‐stage carcinogenesis in mouse skin and correlates with the metastatic potential of murine fibroblasts

1990 • 118 citations

44-kDal bone phosphoprotein (osteopontin) antigenicity at ectopic sites in newborn rats: kidney and nervous tissues

1988 • 116 citations

Molecular cloning and sequencing of cDNA encoding urinary stone protein, which is identical to osteopontin

1992 • 105 citations

Multiple forms of SppI (secreted phosphoprotein, osteopontin) synthesized by normal and transformed rat bone cell populations: Regulation by TGF-β

1989 • 103 citations

Induction of expression of osteopontin (OPN; secreted phosphoprotein) in metastatic, ras-transformed NIH 3T3 cells.

1992 • 97 citations

Ultrastructural Immunolocalization of Osteopontin in Metaphyseal and Cortical Bone

1991 • 89 citations

Fate of nerve fibers in necrotic, healing, and healed rat myocardium.

1990 • 85 citations

Contractile cells in rat myocardial scar tissue.

1991 • 84 citations

Characterization of the promoter region of the porcine opn (osteopontin, secreted phosphoprotein 1) gene

1992 • 65 citations

Gene Regulation in Macrophage Activation: Differential Regulation of Genes Encoding for Tumor Necrosis Factor, Interleukin-1, JE, and KC by interferon-γ and Lipopolysaccharide

1990 • 63 citations

Type β Transforming Growth Factor Regulates Expression of Genes Encoding Bone Matrix Proteins

1989 • 61 citations

Regulated temporal and spatial expression of the calcium‐binding proteins calcyclin and opn (osteopontin) in mouse tissues during pregnancy

1992 • 56 citations

Adhesion of metastatic, ras-transformed NIH 3T3 cells to osteopontin, fibronectin, and laminin.

1993 • 52 citations

Regulation of transformation-sensitive secreted phosphoprotein (SPPI/osteopontin) expression by transforming growth factor-β. Comparisons with expression of SPARC (secreted acidic cysteine-rich protein)

1991 • 50 citations

Fracture healing induces expression of the proto‐oncogene c‐fos in vivo Possible involvement of the Fos protein in osteoblastic differentiation

1991 • 42 citations

Basal lamina of rat myocardium. Its fate after death of cardiac myocytes.

1988 • 32 citations

Myocyte reactions at the borders of injured and healing rat myocardium.

1988 • 32 citations

The Activated Macrophage and Granulomatous Inflammation

1989 • 30 citations

Repair of intra-membranous bone fractures and defects in rats

1991 • 21 citations

Mechanism of fibronectin enhancement of group B streptococcal phagocytosis by human neutrophils and culture-derived macrophages

1993 • 20 citations

A re‐examination of the molecular basis of cell movement

1993 • 13 citations

Freeze-thaw injury of rat heart across an intact diaphragm: a new model for the study of the response of myocardium to injury

1985 • 13 citations