Complex Regulation of Telomerase Activity

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1989 • 1,509 citations

Inhibition of telomerase limits the growth of human cancer cells

1999 • 1,032 citations

Activation of telomerase in human lymphocytes and hematopoietic progenitor cells.

1995 • 871 citations

Telomerase activation by the E6 gene product of human papillomavirus type 16

1996 • 825 citations

Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP)

1997 • 687 citations

A Mammalian Telomerase-Associated Protein

1997 • 656 citations

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

1999 • 545 citations

Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts.

1998 • 493 citations

Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit

1999 • 479 citations

Human telomerase contains evolutionarily conserved catalytic and structural subunits

1997 • 476 citations

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

1999 • 473 citations

Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase

1998 • 419 citations

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

1999 • 404 citations

Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.

1999 • 392 citations

Regulation of Telomerase Activity in Immortal Cell Lines

1996 • 360 citations

Human telomeres are attached to the nuclear matrix.

1992 • 334 citations

Mechanism of Telomerase Induction during T Cell Activation

1996 • 291 citations

Telomere lengthening and telomerase activation during human B cell differentiation

1997 • 263 citations

Induction of hTERT Expression and Telomerase Activity by Estrogens in Human Ovary Epithelium Cells

2000 • 255 citations

Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia.

2001 • 241 citations

Cutting Edge: Telomerase Activation in Human T Lymphocytes Does Not Require Increase in Telomerase Reverse Transcriptase (hTERT) Protein But Is Associated with hTERT Phosphorylation and Nuclear Translocation

2001 • 235 citations

Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

1999 • 234 citations

Cell cycle-dependent modulation of telomerase activity in tumor cells.

1996 • 226 citations

DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene.

1999 • 214 citations

Telomerase Is Controlled by Protein Kinase Cα in Human Breast Cancer Cells

1998 • 213 citations

Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry

2000 • 206 citations

Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with Age

2000 • 200 citations

Protein Phosphatase 2A Inhibits Nuclear Telomerase Activity in Human Breast Cancer Cells

1997 • 197 citations

Methylation of the human telomerase gene CpG island.

2000 • 180 citations

Lack of cell cycle regulation of telomerase activity in human cells

1997 • 162 citations

Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

1997 • 160 citations

Frequent amplification of the telomerase reverse transcriptase gene in human tumors.

2000 • 157 citations

Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis

1998 • 155 citations

Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase

2000 • 153 citations

Bcl-2 Modulates Telomerase Activity

1997 • 149 citations

Telomere loss in cells treated with cisplatin

1998 • 147 citations

Telomerase activity and telomere length in acute and chronic leukemia, pre- and post-ex vivo culture.

2000 • 140 citations

Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development

2001 • 139 citations

The roles of telomeres and telomerase in cell life span

1996 • 137 citations

Telomere length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukemia.

1998 • 127 citations

Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase.

2001 • 117 citations

Telomerase Repressor Sequences on Chromosome 3 and Induction of Permanent Growth Arrest in Human Breast Cancer Cells

1999 • 116 citations

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

2001 • 112 citations

Telomerase Activity Is Induced in Human Peripheral B Lymphocytes by the Stimulation to Antigen Receptor

1997 • 110 citations

High telomerase reverse transcriptase (hTERT) messenger RNA level correlates with tumor recurrence in patients with favorable histology Wilms' tumor.

1999 • 103 citations

Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents.

1996 • 103 citations

Interferon α down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells

2000 • 101 citations

Real-Time Quantification in Plasma of Human Telomerase Reverse Transcriptase (hTERT) mRNA: A Simple Blood Test to Monitor Disease in Cancer Patients

2001 • 100 citations

Evidence for UV-associated activation of telomerase in human skin.

1997 • 96 citations

Telomeres and Their Synthesis

1990 • 93 citations

Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro

1999 • 90 citations

Autocrine transforming growth factor beta suppresses telomerase activity and transcription of human telomerase reverse transcriptase in human cancer cells.

2001 • 85 citations

Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induces cellular senescence

1998 • 79 citations

Supression of telomerase activity in HL60 cells after treatment with differentiating agents.

1996 • 72 citations

Immortalization of human mammary epithelial cells transfected with mutant p53 (273his).

1996 • 72 citations

Decrease in telomerase activity in U-87MG human glioblastomas after treatment with an antagonist of growth hormone-releasing hormone

1999 • 71 citations

Telomerase activity in relation to p53 status and clinico-pathological parameters in breast cancer

1998 • 59 citations

Effects of tamoxifen on telomerase activity in breast carcinoma cell lines

1999 • 57 citations

Telomerase Activity in Human Leukemic Cell Lines Is Inhibited by Antisense Pentadecadeoxynucleotides Targeted against c-myc mRNA

1997 • 55 citations

Telomerase is regulated by protein kinase C-ζ in human nasopharyngeal cancer cells

2001 • 55 citations

Down-Regulation of Telomerase Activity in Malignant Lymphomas by Radiation and Chemotherapeutic Agents

2001 • 51 citations

Telomerase Activity as a Prognostic Factor in Neuroblastomas

2001 • 45 citations

Reduction of telomerase activity in human liver cancer cells by a histone deacetylase inhibitor

2001 • 41 citations

Effect of oncogene expression on telomerase activation and telomere length in human endothelial, fibroblast and prostate epithelial cells.

1998 • 27 citations

Telomerase is regulated by protein kinase C-ζ in human nasopharyngeal cancer cells

2001 • 23 citations

Telomerase activation and p53 mutations in urethane-induced A/J mouse lung tumor development

2001 • 18 citations

Interaction between dexamethasone and butyrate in apoptosis induction: non-additive in thymocytes and synergistic in a T cell-derived leukemia cell line

1999 • 15 citations

Adenovirus-mediated over-expression of p21Waf-1 differentially affects the proliferation, telomerase activity, and expression of glial fibrillary acidic protein in human glioma cells.

1999 • 12 citations