Telomerase is regulated by protein kinase C-ζ in human nasopharyngeal cancer cells

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

A survey of telomerase activity in human cancer

1997 • 2,747 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

A telomerase component is defective in the human disease dyskeratosis congenita

1999 • 1,135 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

1997 • 946 citations

Direct activation of TERT transcription by c-MYC

1999 • 871 citations

A Mammalian Telomerase-Associated Protein

1997 • 656 citations

Myc activates telomerase

1998 • 650 citations

Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas

1998 • 614 citations

Functional requirement of p23 and Hsp90 in telomerase complexes

1999 • 538 citations

TELOMERASES

1992 • 531 citations

Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit

1999 • 479 citations

Cloning of human telomerase catalytic subunit(hTERT)gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells

2002 • 475 citations

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

1999 • 473 citations

The telomerase reverse transcriptase: components and regulation

1998 • 435 citations

Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase

1998 • 419 citations

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

1999 • 404 citations

Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues.

1996 • 403 citations

Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.

1999 • 392 citations

TLP1: A Gene Encoding a Protein Component of Mammalian Telomerase Is a Novel Member of WD Repeats Family

1997 • 379 citations

Reconstitution of human telomerase activity in vitro

1998 • 347 citations

Mechanism of Telomerase Induction during T Cell Activation

1996 • 291 citations

Studies of the molecular mechanisms in the regulation of telomerase activity

1999 • 255 citations

Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

1999 • 234 citations

Telomerase Is Controlled by Protein Kinase Cα in Human Breast Cancer Cells

1998 • 213 citations

Protein Phosphatase 2A Inhibits Nuclear Telomerase Activity in Human Breast Cancer Cells

1997 • 197 citations

Inhibition of Telomerase Activity by PKC Inhibitors in Human Nasopharyngeal Cancer Cells in Culture

1997 • 138 citations

Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms

1999 • 85 citations

Telomerase Activity Is Induced by the Stimulation to Antigen Receptor in Human Peripheral Lymphocytes

1996 • 83 citations

Reconstitution of Wild-Type or Mutant Telomerase Activity in Telomerase-Negative Immortal Human Cells

1998 • 61 citations

Telomerase Activity in Human Leukemic Cell Lines Is Inhibited by Antisense Pentadecadeoxynucleotides Targeted against c-myc mRNA

1997 • 55 citations

Polymerase Chain Reaction‐based Enzyme Immunoassay for Quantitation of Telomerase Activity: Application to Colorectal Cancers^†

1999 • 24 citations