Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin.

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

1990 • 9,412 citations

Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

1998 • 1,927 citations

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

1999 • 1,001 citations

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21^Cip1

1997 • 464 citations

Low molecular weight heparins: prophylaxis of venous thromboembolism in surgical patients.

1997 • 399 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

BCL-2: Prevention of Apoptosis as a Mechanism of Drug Resistance

1995 • 323 citations

Novel mechanisms of drug resistance in leukemia

2000 • 205 citations

Calculation of the EC50 and Its Confidence Interval When Subtoxic Stimulus Is Present

1993 • 190 citations

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

1999 • 151 citations

Alteration of caspase-3 (CPP32/Yama/apopain) in wild-type MCF-7, breast cancer cells.

1999 • 138 citations

Apoptosis and cancer chemotherapy

1994 • 109 citations

A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase

1993 • 107 citations

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

1998 • 100 citations

The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors

2000 • 97 citations

Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

2000 • 90 citations

Molecular mechanisms of drug resistance in tumours

1995 • 81 citations

Synergism of v-myc and v-Ha-ras in the in Vitro Neoplastic Progression of Murine Lymphoid Cells

1986 • 78 citations

A conditionally-active form of MEK1 results in autocrine transformation of human and mouse hematopoietic cells

2000 • 76 citations

Abrogation of c-Raf expression induces apoptosis in tumor cells

1998 • 69 citations

Anticancer drug resistance and inhibition of apoptosis.

1994 • 59 citations

Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines

1999 • 47 citations

High Raf-1 kinase activity protects human tumor cells against paclitaxel-induced cytotoxicity.

1998 • 44 citations

Effect of the activated Raf protein kinase on the human multidrug resistance 1 (MDR1) gene promoter

1996 • 40 citations

Oncogenic effects of overexpression of the interleukin-3 receptor on hematopoietic cells.

1996 • 38 citations

Retroviral infection can abrogate the factor-dependency of hematopoietic cells by autocrine and non-autocrine mechanisms depending on the presence of a functional viral oncogene.

1993 • 37 citations

The biology of radioresistance: similarities, differences and interactions with drug resistance

1993 • 23 citations

DIFFERENTIAL-EFFECTS OF VIRAL AND CELLULAR ONCOGENES ON THE GROWTH FACTOR-DEPENDENCY OF HEMATOPOIETIC-CELLS

1995 • 19 citations

Drug resistance, the last frontier?

1991 • 5 citations