Antiestrogens and selective estrogen receptor modulators reduce prostate cancer risk

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

Cancer statistics, 1999

1999 • 3,154 citations

ERβ: Identification and characterization of a novel human estrogen receptor

1996 • 2,262 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

Generation and reproductive phenotypes of mice lacking estrogen receptor β

1998 • 1,680 citations

Prostate cancer in a transgenic mouse.

1995 • 1,295 citations

Effects of Tamoxifen on Bone Mineral Density in Postmenopausal Women with Breast Cancer

1992 • 1,139 citations

Human Estrogen Receptor β-Gene Structure, Chromosomal Localization, and Expression Pattern1

1997 • 1,098 citations

Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse

1997 • 968 citations

A mutation in the ligand binding domain of the androgen receptor of human INCaP cells affects steroid binding characteristics and response to anti-androgens

1990 • 948 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β

1997 • 862 citations

Metastatic prostate cancer in a transgenic mouse.

1996 • 595 citations

Risk of endometrial cancer after tamoxifen treatment of breast cancer

1994 • 574 citations

Adjuvant Tamoxifen Therapy for Early Stage Breast Cancer and Second Primary Malignancies

1995 • 515 citations

Inhibition of protein kinase C by tamoxifen.

1985 • 464 citations

Naturally occurring oestrogens in foods—A review

1985 • 452 citations

Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I.

1993 • 442 citations

The induction of prostatic hypertrophy in the dog with androstanediol.

1976 • 420 citations

Serum testosterone levels in healthy young black and white men.

1986 • 398 citations

Androgen-independent prostate cancer progression in the TRAMP model.

1997 • 359 citations

Identification of Estrogen Receptor β2, A Functional Variant of Estrogen Receptor β Expressed in Normal Rat Tissues

1998 • 313 citations

Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase

1984 • 296 citations

Cardiac and vascular morbidity in women receiving adjuvant tamoxifen for breast cancer in a randomised trial

1995 • 284 citations

Comparative distribution of estrogen receptor-α (ER-α) and β (ER-β) mRNA in the rat pituitary, gonad, and reproductive tract

1998 • 280 citations

Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl:CD(BR) rats.

1993 • 268 citations

Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells

1992 • 239 citations

Estrogen Receptor Expression in Prostate Cancer and Premalignant Prostatic Lesions

1999 • 237 citations

Diet and Its Preventive Role in Prostatic Disease

1999 • 226 citations

Agonistic Effect of Tamoxifen Is Dependent on Cell Type, ERE-Promoter Context, and Estrogen Receptor Subtype: Functional Difference between Estrogen Receptors α and β

1997 • 224 citations

Biochemical Alterations in Sex Hormone-Induced Hyperplasia and Dysplasia of the Dorsolateral Prostates of Noble Rats

1988 • 187 citations

Role of peptide growth factors in the prostate: A review

1993 • 165 citations

Estrogen Receptor-β Messenger Ribonucleic Acid Ontogeny in the Prostate of Normal and Neonatally Estrogenized Rats*

1998 • 163 citations

EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium

1999 • 163 citations

Toremifene prevents prostate cancer in the transgenic adenocarcinoma of mouse prostate model.

2002 • 154 citations

Immunohistochemistry and biochemistry in detection of androgen, progesterone, and estrogen receptors in benign and malignant human prostatic tissue

1992 • 153 citations

Tamoxifen, serum lipoproteins and cardiovascular risk

1988 • 147 citations

Androgen‐supported estrogen‐enhanced epithelial proliferation in the prostates of intact noble rats

1989 • 146 citations

Regulation of cytoplasmic dihydrotestosterone binding in dog prostate by 17 beta-estradiol.

1979 • 141 citations

Uterine bioassay of tamoxifen, trioxifene and a new estrogen antagonist (LY117018) in rats and mice

1980 • 137 citations

Estrogen receptor-?: Implications for the prostate gland

1999 • 137 citations

Transcriptional Regulation of the Human Quinone Reductase Gene by Antiestrogen-liganded Estrogen Receptor-α and Estrogen Receptor-β

1998 • 134 citations

Functional Analysis of a Novel Estrogen Receptor-β Isoform

1999 • 131 citations

Review of Peptide Growth Factors in Benign Prostatic Hyperplasia and Urological Malignancy

1995 • 129 citations

Chemoprevention of Prostate Cancer: Concepts and Strategies

1999 • 124 citations

Changes in the endocrine environment of the human prostate transition zone with aging: Simultaneous quantitative analysis of prostatic sex steroids and comparison with human prostatic histological composition

2000 • 119 citations

Growth of LNCaP human prostate cancer cells is stimulated by estradiol via its own receptor.

1995 • 117 citations

Raloxifene, a mixed estrogen agonist/antagonist, induces apoptosis in androgen-independent human prostate cancer cell lines.

2002 • 108 citations

Rat Estrogen Receptor-α and -β, and Progesterone Receptor mRNA Expression in Various Prostatic Lobes and Microdissected Normal and Dysplastic Epithelial Tissues of the Noble Rats

1998 • 106 citations

Chemopreventive activity of tamoxifen, N-(4-hydroxyphenyl)retinamide, and the vitamin D analogue Ro24-5531 for androgen-promoted carcinomas of the rat seminal vesicle and prostate.

1995 • 97 citations

Prostatic Dysplasia Associated With Increased Expression of C-Myc in Neonatally Estrogenized Mice

1993 • 77 citations

Expression of estrogen receptor in diseased human prostate assessed by non‐radioactive in situ hybridization and immunohistochemistry

1995 • 72 citations

The role of soy phytoestrogens in prostate cancer

2002 • 68 citations

Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21waf1/cip1

1998 • 64 citations

Differential effects of diethylstilbestrol and estradiol-17β in combination with testosterone on rat prostate lobes

1992 • 62 citations

The Selective Estrogen Receptor Modulator, Raloxifene: An Overview of Nonclinical Pharmacology and Reproductive and Developmental Testing

1998 • 53 citations

The periurethral zone of the prostate of the cynomolgus monkey is the most sensitive prostate part for an estrogenic stimulus

1988 • 53 citations

Hormonal regulation of the androgen receptor expression in human prostatic cells in culture

1998 • 52 citations

Comparison of DNA reactivity of the polyphenylethylene hormonal agents diethylstilbestrol, tamoxifen and toremifene in rat and hamster liver

1994 • 50 citations

Quantitation of cytosolic and nuclear estrogen and progesterone receptor in benign, untreated, and treated malignant human prostatic tissue by radioligand binding and enzyme-immunoassays

1990 • 45 citations

Concentration and cellular distribution of androgen receptor in human prostatic neoplasia: Can estrogen treatment increase androgen receptor content?

1983 • 40 citations

Cancer development in male reproductive tract in rats given diethylstilbestrol at neonatal age.

1978 • 34 citations

Keoxifene shows pure antiestrogenic activity in pituitary gonadotrophs

1985 • 33 citations

Prevention of prostate-related cancers in Lobund-Wistar rats

1999 • 30 citations

ENDOCRINOLOGY OF THE PROSTATE

1939 • 30 citations

Introductory remarks: Development of chemopreventive agents for prostate cancer

1992 • 20 citations

An Evaluation of the Novel Selective Estrogen Receptor Modulator, Idoxifene, for Effects on Reproduction in Rats and Rabbits

1998 • 19 citations

Estrogen Receptors in the Human Male Prostatic Urethra and Prostate in Prostatic Cancer and Benign Prostatic Hyperplasia

1999 • 18 citations

Regulation of prostate growth

2001 • 17 citations

An Evaluation of the Novel Selective Estrogen Receptor Modulator, Idoxifene, for Effects on Reproduction in Rats and Rabbits

1998 • 3 citations