Platelet Prostaglandin Receptors

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

Cloning and expression of cDNA for a human thromboxane A2 receptor

1991 • 680 citations

Modulation of human platelet adenylate cyclase by prostacyclin (PGX)

1977 • 659 citations

Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype.

1993 • 475 citations

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

1994 • 441 citations

Cloning and expression of a cDNA for the human prostanoid FP receptor.

1994 • 386 citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

1991 • 373 citations

Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.

1994 • 357 citations

Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species

1978 • 339 citations

Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.

1996 • 298 citations

Testosterone Increases Human Platelet Thromboxane A ₂ Receptor Density and Aggregation Responses

1995 • 289 citations

A novel inhibitory prostanoid receptor in piglet saphenous vein

1994 • 273 citations

Site-directed mutagenesis of m1 muscarinic acetylcholine receptors: conserved aspartic acids play important roles in receptor function.

1989 • 258 citations

Thromboxane, Prostaglandin and Leukotriene Receptors

1989 • 258 citations

cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla

1994 • 255 citations

Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene.

1994 • 226 citations

Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins.

1993 • 214 citations

The classification of prostaglandin DP‐receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist

1989 • 196 citations

Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.

1994 • 188 citations

Cloning and expression of a cDNA for the human prostanoid IP receptor.

1994 • 187 citations

Prostacyclin is a specific effector of adipose cell differentiation. Its dual role as a cAMP- and Ca(2+)-elevating agent.

1992 • 167 citations

Mouse thromboxane A2 receptor: cDNA cloning, expression and Northern blot analysis

1992 • 162 citations

Inositol 1,4,5-triphosphate-induced granule secretion in platelets. Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein-dependent mechanism distinct from that of thrombin.

1987 • 156 citations

Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets

1989 • 154 citations

Molecular biology of prostanoid receptors; an overview

1995 • 145 citations

Cloning and Expression of the EP2 Subtype of Human Receptors for Prostaglandin E2

1993 • 144 citations

Genistein, a protein tyrosine kinase inhibitor, inhibits thromboxane A2-mediated human platelet responses.

1991 • 143 citations

The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems.

1990 • 141 citations

Characterization and chromosomal mapping of the human thromboxane A2 receptor gene.

1993 • 140 citations

Two isoforms of prostaglandin E receptor EP3 subtype. Different COOH-terminal domains determine sensitivity to agonist-induced desensitization

1993 • 134 citations

Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.

1994 • 118 citations

Cloning and expression of three isoforms of the human EP₃ prostanoid receptor

1994 • 117 citations

Identification of Gq as one of the G-proteins which copurify with human platelet thromboxane A2/prostaglandin H2 receptors.

1993 • 116 citations

Signaling through G Proteins and G Protein-coupled Receptors during Platelet Activation

1993 • 116 citations

In vitro characterization of prostanoid FP‐, DP‐, IP‐ and TP‐receptors on the non‐pregnant human myometrium

1992 • 113 citations

Cloning and expression of a cDNA for the human prostacyclin receptor

1994 • 106 citations

Characterization of the Platelet Prostaglandin D2 Receptor

1979 • 103 citations

Molecular cloning and expression of human EP₃ receptors: evidence of three variants with differing carboxyl termini

1994 • 100 citations

Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogues

1983 • 97 citations

Different responsiveness of prostaglandin D₂‐sensitive systems to prostaglandin D₂ and its analogues

1985 • 96 citations

Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites.

1993 • 94 citations

Receptor-mediated mitogenic effect of thromboxane A2 in vascular smooth muscle cells

1990 • 93 citations

Alternative splicing generates multiple isoforms of a rabbit prostaglandin E2 receptor.

1994 • 92 citations

Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors

1989 • 87 citations

Molecular Cloning and Intrarenal Localization of Rat Prostaglandin E2 Receptor EP3 Subtype

1993 • 82 citations

Regulation of thromboxane receptor activation in human platelets.

1989 • 81 citations

Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors

1983 • 81 citations

Molecular Characterization of the Mouse Prostanoid EP1 Receptor Gene

1995 • 76 citations

Cloning and Expression of the EP3-Subtype of Human Receptors for Prostaglandin E2

1994 • 75 citations

Binding of a radioiodinated 13‐azapinane thromboxane antagonist to platelets: correlation with antiaggregatory activity in different species

1986 • 73 citations

Prostaglandin endoperoxide/thromboxane A2 receptor desensitization. Cross-talk with adenylate cyclase in human platelets.

1990 • 71 citations

Distinct platelet thromboxane A2/prostaglandin H2 receptor subtypes. A radioligand binding study of human platelets.

1989 • 67 citations

Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles.

1992 • 65 citations

Phosphorylation and regulated expression of the human thromboxane A2 receptor.

1994 • 65 citations

Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells

1994 • 65 citations

Molecular Characterization of the Mouse Prostanoid EP1 Receptor Gene

1995 • 61 citations

Functional reconstitution of platelet thromboxane A2 receptors with Gq and Gi2 in phospholipid vesicles.

1994 • 60 citations

Cloning and expression of a cDNA for rat prostacyclin receptor

1994 • 57 citations

Thromboxane A2 receptors

1995 • 56 citations

Prostacyclin analogues reduce ADP‐ribosylation of the α‐subunit of the regulatory G_s‐protein and diminish adenosine (A₂) responsiveness of platelets

1987 • 55 citations

Prostaglandin D2 relaxes bovine coronary arteries by endothelium-dependent nitric oxide-mediated cGMP formation.

1992 • 53 citations

Stimulations of arachidonate release and inositol-1,4,5-triphosphate formation are mediated by distinct G-proteins in human platelets

1987 • 52 citations

Potentiation of aggregation and inhibition of adenylate cyclase in human platelets by prostaglandin E analogues

1993 • 52 citations

Solubilization of prostacyclin membrane receptors from human platelets

1989 • 49 citations

Identification and characterisation of a prostacyclin- like receptor in bovine coronary arteries using a specific and stable prostacyclin analogue, ciloprost, as radioactive ligand

1982 • 48 citations

Identification of a prostacyclin receptor coupled to the adenylate cyclase system via a stimulatory GTP-binding protein in mouse mastocytoma P-815 cells

1990 • 46 citations

Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation

1993 • 43 citations

Stable 9ß- or 11α-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor

1988 • 43 citations

cDNA cloning of a thromboxane A2 receptor from rat astrocytes

1995 • 41 citations

Structural Organization and Chromosomal Assignment of the Human Prostacyclin Receptor Gene

1995 • 37 citations

Two Isoforms of Prostaglandin E Receptor EP3 Subtype

1993 • 35 citations

The effects of PGE2 and CL 115,347, an antihypertensive PGE2 analogue, on human blood platelet behaviour and vascular contractility

1985 • 33 citations

Characterization of prostaglandin (PG)-binding sites expressed on human basophils. Evidence for a prostaglandin E1, I2, and a D2 receptor.

1992 • 33 citations

THROMBOXANE AUGMENTATION OF ALLOREACTIVE T CELL FUNCTION

1992 • 33 citations

Separate receptors for prostacyclin and prostaglandin E2 on human gel-filtered platelets.

1986 • 32 citations

(5Z)‐carbacyclin discriminates between prostacyclin‐receptors coupled to adenylate cyclase in vascular smooth muscle and platelets

1987 • 30 citations

Prostaglandin binding sites in human polymorphonuclear neutrophils

1989 • 30 citations

PGD2 and its mimetic ZK 110.841 are potent inhibitors of receptor-mediated activation of human neutrophils.

1991 • 29 citations

Homologous desensitization of human platelet thromboxane A2/prostaglandin H2 receptors.

1992 • 29 citations

Prostaglandin-stimulated GTP hydrolysis associated with activation of adenylate cyclase in human platelet membranes.

1982 • 29 citations

Protein-Tyrosine Kinase p72syk Is Activated by Thromboxane A2 Mimetic U44069 in Platelets

1993 • 29 citations

Cyclic AMP turnover in response to prostaglandins in intact platelets: evidence for separate stimulatory and inhibitory prostaglandin receptors.

1988 • 29 citations

Prostacyclin binding to guinea pig pulmonary receptors

1981 • 28 citations

Comparison of the Anticoagulant and Antithrombotic Effects of Synthetic Thrombin and Factor Xa Inhibitors

1990 • 27 citations

Androgen regulation of thromboxane A2/prostaglandin H2 receptor expression in human erythroleukemia cells

1993 • 26 citations

Expression of thromboxane A2 receptor in cultured human erythroleukemia cells and its induction by 12-O-tetradecanoylphorbol-13-acetate

1989 • 26 citations

Identification of the prostacyclin receptor by use of [15-3H1]19-(3-azidophenyl)-20-norisocarbacyclin, an irreversible specific photoaffinity probe.

1992 • 25 citations

Characterization by photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 receptor: evidence for N-linked glycosylation

1992 • 21 citations

Agonist-induced phosphorylation of human platelet TXA2/PGH2 receptors

1994 • 20 citations

Membranes and receptors

1977 • 18 citations

Gene expression during phorbol ester-induced differentiation of cultured human megakaryoblastic cells

1994 • 18 citations

Mechanism for homologous downregulation of thromboxane A2 receptors in cultured human chronic myelogenous leukemia (K562) cells.

1991 • 16 citations

Regulation of response to thromboxane A2 in CHRF-288 megakaryocytic cells

1992 • 16 citations

DESENSITIZATION OF PROSTACYCLIN RECEPTORS IN A NEURONAL HYBRID CELL LINE

1982 • 16 citations

DIVALENT CATIONS INCREASE [³H]‐PROSTACYCLIN BINDING TO MEMBRANES OF NEURONAL SOMATIC HYBRID CELLS

1981 • 15 citations

Modulation of thromboxane receptor activation in rat glomerular mesangial cells

1994 • 14 citations

Guanine nucleotide sensitivity of [3H]iloprost binding to prostacyclin receptors

1991 • 14 citations

Cyclic-AMP-dependent Ca2+ influx elicited by prostaglandin D2 in freshly isolated nonchromaffin cells from bovine adrenal medulla

1993 • 14 citations

Thromboxane A₂analogue U 46619 enhances tumour cell proliferation in HeLa cells via specific receptors which are apparently distinct from TXA₂ receptors on human platelets

1993 • 9 citations

Diminished Inhibition of Adhesion Molecule Expression in Prostacyclin Receptor Desensitized Human Platelets

1995 • 7 citations

Protein-tyrosine kinase p72[syk] is activated by thromboxane A[2] mimetic U44069 in platelets

1995 • 3 citations