Cytotoxic Effects of the Clostridium difficile Toxins

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Clostridium difficile Colitis

1994 • 1,328 citations

Glucosylation of Rho proteins by Clostridium difficile toxin B

1995 • 1,025 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

1995 • 418 citations

Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers.

1988 • 398 citations

Identification of Toxin A-Negative, Toxin B-Positive Clostridium difficile by PCR

1998 • 360 citations

Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro.

1995 • 344 citations

Bacterial Protein Toxins: An Overview

2003 • 335 citations

A Novel Toxinotyping Scheme and Correlation of Toxinotypes with Serogroups of Clostridium difficile Isolates

1998 • 324 citations

Cell surface binding site for Clostridium difficile enterotoxin: evidence for a glycoconjugate containing the sequence Gal alpha 1-3Gal beta 1-4GlcNAc

1986 • 242 citations

Clostridium difficile toxin B disrupts the barrier function of T84 monolayers

1992 • 194 citations

Increased substance P responses in dorsal root ganglia and intestinal macrophages duringClostridium difficiletoxin A enteritis in rats

1997 • 165 citations

Rho proteins play a critical role in cell migration during the early phase of mucosal restitution.

1997 • 163 citations

Localization of the Glucosyltransferase Activity of Clostridium difficile Toxin B to the N-terminal Part of the Holotoxin

1997 • 162 citations

Defective acidification of endosomes in Chinese hamster ovary cell mutants "cross-resistant" to toxins and viruses.

1983 • 153 citations

Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells.

1997 • 149 citations

Molecular mimicry in the recognition of glycosphingolipids by Galα3Galβ4GlcNAcβ-binding Clostridium difficile toxin A, human natural anti α-galactosyl IgG and the monoclonal antibody Gal-13: characterization of a binding-active human glycosphingolipid, non-identical with the animal receptor

1996 • 114 citations

Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A.

1996 • 110 citations

A Novel Cytotoxin from Clostridium difficileSerogroup F Is a Functional Hybrid between Two Other Large Clostridial Cytotoxins

1999 • 108 citations

Cellular UDP-Glucose Deficiency Caused by a Single Point Mutation in the UDP-Glucose Pyrophosphorylase Gene

1997 • 84 citations

Cellular internalisation of Clostridium difficile toxin A

1987 • 83 citations

Clostridium difficile toxin A and its effects on cells

1991 • 82 citations

Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins

1998 • 80 citations

Bacterial toxins : tools in cell biology and pharmacology

1997 • 71 citations

Closing in on the toxic domain through analysis of a variant Clostridium difficile cytotoxin B

1995 • 68 citations

Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1beta, tumor necrosis factor alpha, and leukotrienes

1997 • 67 citations

Lysosomal involvement in cellular intoxication with Clostridium difficile toxin B

1986 • 66 citations

The C-terminal ligand-binding domain of Clostridium difficile toxin A (TcdA) abrogates TcdA-specific binding to cells and prevents mouse lethality

2006 • 61 citations

Transient expression of RhoA, -B, and -C GTPases in HeLa cells potentiates resistance to Clostridium difficile toxins A and B but not to Clostridium sordellii lethal toxin

1995 • 58 citations

Interaction of Clostridium difficile toxin A with cultured cells: cytoskeletal changes and nuclear polarization

1990 • 58 citations

UDP-Glucose Deficiency in a Mutant Cell Line Protects against Glucosyltransferase Toxins from Clostridium difficile and Clostridium sordellii

1996 • 49 citations

Increased substance P receptor expression by blood vessels and lymphoid aggregates inClostridium difficile-induced pseudomembranous colitis

1996 • 48 citations

Effects of Clostridium Difficile toxins A and B on cytoskeleton organization in HEp-2 cells: A comparative morphological study

1989 • 48 citations

Effects of Toxin A fromClostridium difficileon Mast Cell Activation and Survival

1998 • 44 citations

The involvement of macrophage‐derived tumour necrosis factor and lipoxygenase products on the neutrophil recruitment induced by Clostridium difficile toxin B

1997 • 43 citations

Bacterial protein toxins

1995 • 32 citations

Epidermal growth factor attenuatesClostridium difficiletoxin A- and B-induced damage of human colonic mucosa

1997 • 26 citations

The Enzymatic Domain ofClostridium difficileToxin A Is Located within Its N-Terminal Region

1998 • 26 citations

Morphological changes in adherent cells induced by Clostridium difficile toxins

1991 • 23 citations

Morphological changes of cultured endothelial cells after microinjection of toxins that act on the cytoskeleton

1992 • 22 citations

Effect of Clostridium difficile enterotoxin A on ultrastructure of Chinese hamster ovary cells

1989 • 21 citations

Microfilament-disrupting Clostridium difficile toxin B causes multinucleation of transformed cells but does not block capping of membrane Ig.

1990 • 20 citations

Cytotoxicity of Clostridium difficile toxin A for human colonic and pancreatic carcinoma cell lines.

1992 • 11 citations

Toxin B Induces Apoptosis in Intestinal Cultured Cells.

1999 • 2 citations