Pathways of Ca2+ influx at the plasma membrane: Voltage-, receptor-, and second messenger-operated channels

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Three types of neuronal calcium channel with different calcium agonist sensitivity

1985 • 2,212 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Calcium channel modulation by neurotransmitters, enzymes and drugs

1983 • 1,267 citations

Sodium and calcium channels in bovine chromaffin cells

1982 • 983 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones

1984 • 878 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

A novel type of cardiac calcium channel in ventricular cells

1985 • 745 citations

Calcium Channels in Excitable Cell Membranes

1983 • 725 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

The Calcium Messenger System

1986 • 669 citations

GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels

1986 • 666 citations

Inactivation of Ca channels

1984 • 616 citations

Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release

1985 • 609 citations

MOLECULAR PROPERTIES OF VOLTAGE-SENSITIVE SODIUM CHANNELS

1986 • 577 citations

Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue

1985 • 527 citations

New developments in calcium ion channel antagonists

1983 • 525 citations

Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration

1986 • 489 citations

Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules

1984 • 469 citations

The Nicotinic Cholinergic Receptor: Correlation of Molecular Structure with Functional Properties

1982 • 456 citations

Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor α-subunit

1986 • 444 citations

Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization

1986 • 414 citations

Two types of calcium channels in the somatic membrane of new‐born rat dorsal root ganglion neurones.

1985 • 412 citations

Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel

1986 • 405 citations

Nicotinic receptor of acetylcholine: structure of an oligomeric integral membrane protein

1984 • 373 citations

Effects of dopamine and noradrenaline on Ca channels of cultured sensory and sympathetic neurons of chick

1986 • 316 citations

Effect of inositol-1,4,5-trisphosphate on isolated subcellular fractions of rat pancreas

1984 • 305 citations

A saturable receptor for 32P-inositol-l,4,5-trisphosphate in hepatocytes and neutrophils

1986 • 296 citations

Properties of two types of calcium channels in clonal pituitary cells.

1986 • 280 citations

The Calcium Messenger System

1986 • 275 citations

Role of acetylcholine receptor subunits in gating of the channel

1985 • 272 citations

The role of phosphoinositiees in signal transduction

1986 • 225 citations

Ca2+-dependent and -independent release of neurotransmitters from PC12 cells: a role for protein kinase C activation?

1984 • 180 citations

IgE-mediated degranulation of mast cells does not require opening of ion channels

1986 • 179 citations

Tumor promoter phorbol myristate acetate inhibits Ca2+ influx through voltage-gated Ca2+ channels in two secretory cell lines, PC12 and RINm5F.

1986 • 178 citations

The nicotinic acetylcholine receptor and its ion channel

1986 • 169 citations

Noradrenaline, vasopressin and angiotensin increase Ca2+ influx by opening a common pool of Ca2+ channels in isolated rat liver cells

1984 • 164 citations

Electrogenic transport. Fundamental principles and physiological implications.

1984 • 163 citations

The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca2+ channel. Purification and subunit composition.

1985 • 163 citations

Characterization of fMet-Leu-Phe receptor-mediated Ca2+ influx across the plasma membrane of human neutrophils.

1986 • 157 citations

Sodium and calcium fluxes in a clonal nerve cell line.

1979 • 152 citations

Single-channel and whole-cell recordings of mitogen-regulated inward currents in human cloned helper T lymphocytes

1986 • 151 citations

Receptor coupled events in bradykinin action: rapid production of inositol phosphates and regulation of cytosolic free Ca2+ in a neural cell line.

1987 • 138 citations

Calcium Channels in Planar Lipid Bilayers: Insights into Mechanisms of Ion Permeation and Gating

1986 • 131 citations

Regulation of calcium currents by a GTP analogue: Potentiation of (−)-baclofen-mediated inhibition

1986 • 130 citations

Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells.

1984 • 125 citations

Somatostatin, an inhibitor of ACTH secretion, decreases cytosolic free calcium and voltage-dependent calcium current in a pituitary cell line

1986 • 110 citations

Membrane transport of calcium

1982 • 109 citations

Calcium channels in the neuronal membrane

1981 • 109 citations

Activation of 45Ca2+ influx and 22Na+/H+ exchange by epidermal growth factor and vanadate in A431 cells is independent of phosphatidylinositol turnover and is inhibited by phorbol ester and diacylglycerol.

1986 • 101 citations

Calcium shares the limelight in stimulus-secretion coupling

1986 • 97 citations

NMDA Receptors: what do they do?

1986 • 96 citations

Receptor regulation of calcium release and calcium permeability in parotid gland cells

1981 • 89 citations

EGF raises cytosolic Ca2+ in A431 and Swiss 3T3 cells by a dual mechanism

1987 • 89 citations

The epinephrine‐induced activation of the cardiac slow Ca²⁺ channel is mediated by the cAMP‐dependent phosphorylation of calciductin, a 23 000 M_r sarcolemmal protein

1981 • 78 citations

Pertussis toxin blocks angiotensin II‐induced calcium influx but not inositol trisphosphate production in adrenal glomerulosa cell

1986 • 74 citations

Dynamics of intracellular calcium and its possible relationship to phasic transmitter release and facilitation at the frog neuromuscular junction

1984 • 72 citations

Activation of muscarinic receptors in PC12 cells. Stimulation of Ca2+ influx and redistribution

1986 • 67 citations

How many types of calcium channels exist in neurones?

1985 • 67 citations

1,4-Dlhydropyridines as tools in the study of Ca2+ channels

1985 • 47 citations

Activation of calcium mobilization and calcium influx by alpha1-adrenergic receptors in a smooth muscle cell line

1985 • 36 citations

Duration of the calcium signal in the mitogenic stimulation of thymocytes

1983 • 35 citations

Receptor-operated Ca channels

1987 • 31 citations

Voltage-dependent gating of sodium channels: towards an integrated approach

1986 • 30 citations

A flare-induced cascade model of γ-ray bursts

1986 • 13 citations

Toxin probes for voltage sensitive calcium channels

1984 • 12 citations

Neurotransmitters: Modifying channel function

1986 • 8 citations