cAMP Up-Regulates Cell Surface Expression of Lymphocyte CXCR4: Implications for Chemotaxis and HIV-1 Infection

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 ⁺ T Cells

1995 • 2,890 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

1996 • 2,326 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1996 • 1,973 citations

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

1996 • 1,678 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

1996 • 1,482 citations

The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

1997 • 1,414 citations

Change in Coreceptor Use Correlates with Disease Progression in HIV-1–Infected Individuals

1997 • 1,373 citations

The Molecular Biology of Leukocyte Chemoattractant Receptors

1994 • 1,224 citations

Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1

1998 • 1,202 citations

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

1997 • 1,124 citations

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

1997 • 1,073 citations

Corticosteroid‐Mediated Immunoregulation in Man

1982 • 902 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

Molecular cloning and structure of a pre-B-cell growth-stimulating factor.

1994 • 818 citations

Noradrenergic Sympathetic Neural Interactions with the Immune System: Structure and Function

1987 • 747 citations

Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant

1998 • 725 citations

CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

1997 • 722 citations

The syntax of immune-neuroendocrine communication

1994 • 720 citations

Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.

1995 • 676 citations

CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4

1996 • 669 citations

Chemokine receptors: Gateways to inflammation and infection

1996 • 659 citations

HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication

1997 • 564 citations

A new view of prostaglandin E regulation of the immune response

1991 • 535 citations

The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response

1988 • 533 citations

Co-receptors for HIV-1 entry

1997 • 493 citations

Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes.

1996 • 443 citations

In Vitro Behavior of Hematopoietic Progenitor Cells Under the Influence of Chemoattractants: Stromal Cell–Derived Factor-1, Steel Factor, and the Bone Marrow Environment

1998 • 417 citations

Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: Implications for HIV primary infection

1997 • 398 citations

Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines.

1997 • 388 citations

Phorbol Esters and SDF-1 Induce Rapid Endocytosis and Down Modulation of the Chemokine Receptor CXCR4

1997 • 382 citations

The G-Protein Linked Receptor Facts Book

1994 • 292 citations

Regulation of Human Chemokine Receptors CXCR4

1997 • 290 citations

Intracellular and Surface Expression of the HIV-1 Coreceptor CXCR4/Fusin on Various Leukocyte Subsets: Rapid Internalization and Recycling Upon Activation

1998 • 266 citations

Epinephrine-induced changes in the distribution of lymphocyte subsets in peripheral blood of humans.

1983 • 249 citations

Interleukin 10 Increases CCR5 Expression and HIV Infection in Human Monocytes

1998 • 238 citations

Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation.

1990 • 238 citations

Norepinephrine Accelerates HIV Replication Via Protein Kinase A-Dependent Effects on Cytokine Production

1998 • 228 citations

Antiviral Effect and Ex Vivo CD4 ⁺ T Cell Proliferation in HIV-Positive Patients as a Result of CD28 Costimulation

1996 • 219 citations

cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells.

1990 • 218 citations

Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.

1990 • 218 citations

Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent

1997 • 183 citations

Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry.

1997 • 160 citations

The influence of neuroendocrine pathways on lymphocyte migration

1994 • 157 citations

Immunosuppressive retroviral peptides: cAMP and cytokine patterns

1995 • 153 citations

Chemokines

1997 • 145 citations

CD4-Independent Infection by HIV-2 (ROD/B): Use of the 7-Transmembrane Receptors CXCR-4, CCR-3, and V28 for Entry

1997 • 140 citations

Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells.

1991 • 137 citations

Central nervous system influences on lymphocyte migration

1992 • 128 citations

Genomic Organization and Functional Characterization of the Chemokine Receptor CXCR4, a Major Entry Co-receptor for Human Immunodeficiency Virus Type 1

1998 • 118 citations

CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus

1997 • 116 citations

In Vivo Pathogenesis of a Human Immunodeficiency Virus Type 1 Reporter Virus

1998 • 86 citations

Prostaglandin E2 Induces Resistance to Human Immunodeficiency Virus-1 Infection in Monocyte-Derived Macrophages: Downregulation of CCR5 Expression by Cyclic Adenosine Monophosphate

1998 • 76 citations

Increased cyclic adenosine monophosphate levels block progression but not initiation of human T cell proliferation.

1990 • 73 citations

Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.

1993 • 71 citations

Histamine modulation of lymphocyte biology: membrane receptors, signal transduction, and functions.

1987 • 61 citations

Detection and delineation of CXCR-4 (fusin) as an entry and fusion cofactor for T-tropic [correction of T cell-tropic] HIV-1 by three different monoclonal antibodies.

1998 • 51 citations

Human Immunodeficiency Virus Replication: Modulation by Cellular Levels of cAMP

1992 • 48 citations

In Vitro Behavior of Hematopoietic Progenitor Cells Under the Influence of Chemoattractants: Stromal Cell–Derived Factor-1, Steel Factor, and the Bone Marrow Environment

1998 • 43 citations

cAMP Stimulates Human Immunodeficiency Virus (HIV-1)from Latently Infected Cells of Monocyte-Macrophage Lineage: Synergism with TNF-α

1993 • 41 citations

Delineation of CXCR-4 as an entry cofactor for T-tropic HIV-1 by monoclonal antibodies

1997 • 7 citations