Noradrenergic Sympathetic Neural Interactions with the Immune System: Structure and Function

Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones

1986 • 1,521 citations

Noradrenergic and peptidergic innervation of lymphoid tissue

1985 • 996 citations

The immune system as a sensory organ.

1984 • 555 citations

Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

1987 • 555 citations

Immunoregulation mediated by the sympathetic nervous system

1979 • 483 citations

The Immune Response Evokes Changes in Brain Noradrenergic Neurons

1983 • 442 citations

Vasoactive intestinal peptide

1982 • 417 citations

Adrenergic Receptors in Man

1982 • 401 citations

Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding.

1976 • 398 citations

Stress-Induced Suppression of Immunity in Adrenalectomized Rats

1983 • 390 citations

The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues.

1981 • 389 citations

Psychoneuroimmunology

1982 • 366 citations

Noradrenergic sympathetic innervation of the spleen: II. Tyrosine hydroxylase (TH)‐positive nerve terminals form synapticlike contacts on lymphocytes in the splenic white pulp

1987 • 329 citations

Sympathetic innervation of murine thymus and spleen: Evidence for a functional link between the nervous and immune systems

1981 • 325 citations

MRC OX‐19: A monoclonal antibody that labels rat T lymphocytes and augments in vitro proliferative responses

1984 • 305 citations

Lymphocyte blast transformation

1970 • 293 citations

Involvement of peripheral and central catecholamine systems in neural-immune interactions

1985 • 283 citations

Noradrenergic sympathetic innervation of the spleen: I. Nerve fibers associate with lymphocytes and macrophages in specific compartments of the splenic white pulp

1987 • 282 citations

Interaction of vasoactive intestinal peptide with mouse lymphocytes: specific binding and the modulation of mitogen responses.

1984 • 266 citations

Decreased Beta-Adrenergic Receptors on Polymorphonuclear Leukocytes after Adrenergic Therapy

1978 • 261 citations

Hemolytic Plaque Formation by Leukocytes in Vitro CONTROL BY VASOACTIVE HORMONES

1974 • 219 citations

The β-adrenergic receptor in human lymphocytes: Subclassification by the use of a new radio-ligand, (±)−125iodocyanopindolol

1981 • 209 citations

Adrenal Tyrosine Hydroxylase: Compensatory Increase in Activity after Chemical Sympathectomy

1969 • 206 citations

Brain, behavior, and immunity

1987 • 199 citations

Sympathetic innervation of murine thymus and spleen: A comparative histofluorescence study

1981 • 193 citations

Characterization of the beta-adrenergic receptor of the rat peritoneal macrophage.

1985 • 190 citations

Modulation of macrophage-mediated tumoricidal activity by neuropeptides and neurohormones.

1985 • 183 citations

Autonomic nervous system innervation of thymic‐related lymphoid tissue in wildtype and nude mice

1984 • 170 citations

The innervation of the bone marrow in laboratory animals

1968 • 169 citations

Vasoactive intestinal peptide and neuropeptide modulation of the immune response

1985 • 165 citations

Sympathetic innervation of lymph nodes in mice

1984 • 162 citations

Modulation of lymphocyte function by sensory neuropeptides

1985 • 158 citations

Changes in the density of beta adrenergic receptors in rat lymphocytes, heart and lung after chronic treatment with propranolol.

1982 • 158 citations

The influence of intracellular levels of cyclic nucleotides on cell proliferation and the induction of antibody synthesis.

1975 • 154 citations

Beta adrenergic receptors in lymphocyte subpopulations

1980 • 150 citations

Lymph nodes—A possible site for sympathetic neuronal regulation of immune responses

1980 • 141 citations

Norepinephrine and the antibody response.

1985 • 139 citations

Modification of lymphocyte traffic by vasoactive neurotransmitter substances.

1984 • 135 citations

The Presence of a Substance with Sympathin E Properties in Spleen Extracts

1946 • 122 citations

The Noradrenaline Content of the Varicosities of Sympathetic Adrenergic Nerve Terminals in the Rat

1966 • 118 citations

Neurotransmitters, hormones, and cyclic nucleotides in lymphocyte regulation.

1985 • 114 citations

The sympathetic nervous system modulates antibody response to thymus-independent antigens

1981 • 114 citations

Identification of β adrenoceptors during thymocyte ontogeny in mice

1979 • 113 citations

Evidence for a β-adrenergic receptor initiating DNA synthesis in haemopoietic stem cells

1972 • 111 citations

High affinity beta-2-adrenergic receptors in mononuclear leucocytes: Similar density in young and old normal subjects

1981 • 107 citations

Evidence for a neurotransmitter role for epinephrine derived from the adrenal medulla

1982 • 105 citations

Innervation of the periarteriolar lymphatic sheath of the spleen

1979 • 104 citations

Noradrenergic sympathetic innervation of lymphoid tissue in the rabbit appendix: Further evidence for a link between the nervous and immune systems

1981 • 104 citations

Immunoregulation mediated by the sympathetic nervous system, II

1981 • 101 citations

The actions of drugs on the smooth muscle of the capsule and blood vessels of the spleen.

1973 • 101 citations

Beta-Adrenergic Receptors are Different in Subpopulations of Human Circulating Lymphocytes

1984 • 101 citations

Substance P and immunoregulation.

1987 • 100 citations

Studies on the maturation of thymus stem cells The effects of catecholamines, histamine and peptide hormones on the expression of T cell alloantigens

1976 • 98 citations

Distribution of beta-adrenergic receptors on human lymphocyte subpopulations.

1979 • 97 citations

Adrenal involvement in conditioned immunosuppression

1979 • 97 citations

The parallel, time-dependent, bimodal change in lymphocyte cholinergic binding activity and cholinergic influence upon lymphocyte-mediated cytotoxicity after lymphocyte activation.

1981 • 93 citations

On the immunocytochemical localization of the vasoactive intestinal polypeptide.

1979 • 92 citations

Electron-microscopic investigation of filament structures in unmyelinated fibers of cat splenic nerve

1961 • 91 citations

Alterations of monoamines in specific central autonomic nuclei following immunization in mice

1987 • 91 citations

Beta adrenoceptor mediation of the enhancing effect of norepinephrine on the murine primary antibody response in vitro.

1984 • 90 citations

Responses of the isolated, perfused human spleen to sympathetic nerve stimulation, catecholamines and polypeptides

1972 • 86 citations

The detection of β-adrenoceptors on murine lymphocytes

1981 • 82 citations

Electron microscopy of the red pulp of the dog spleen including vascular arrangements, periarterial macrophage sheaths (Ellipsoids), and the contractile, innervated reticular meshwork

1981 • 82 citations

The innervation of the cat spleen

1970 • 81 citations

The role of cyclic nucleotides in lymphocyte activation and function.

1977 • 75 citations

Noradrenergic sympathetic innervation of the spleen: IV. Morphometric analysis in adult and aged F344 rats

1987 • 74 citations

β-adrenergic receptors on splenic lymphocytes from axotomized mice

1984 • 72 citations

Studies of the hemopoietic microenvironment. VIII andrenergic and cholinergic innervation of the murine spleen

1976 • 69 citations

Regulation of the immune system by sympathetic neural mechanisms

1987 • 68 citations

Decreased sympathetic innervation of spleen in aged fischer 344 rats

1987 • 67 citations

Innervation and vascular pharmacodynamics of the mammalian spleen

1985 • 66 citations

Electron microscope study of the white pulp of the mouse spleen

1962 • 65 citations

Noradrenergic sympathetic innervation of the spleen: III. Development of innervation in the rat spleen

1987 • 62 citations

Effects of streptozotocin diabetes on the noradrenergic innervation of the rat heart: A longitudinal histofluorescence and neurochemical study

1982 • 61 citations

On the development of bone marrow innervation in new‐born rats as studied with silver impregnation and electron microscopy,

1969 • 56 citations

Effects of Adrenergic Alpha‐ and Beta‐Receptor Stimulation on the Release of Lymphocytes and Granulocytes from the Spleen

1973 • 56 citations

The structure of the spleen and its functional implications

1964 • 55 citations

Noradrenaline Stores in Nerve Terminals of the Spleen: Changes during Hemorrhagic Shock

1965 • 52 citations

Kinetics of the enhancing effect produced by norepinephrine and terbutaline on the murine primary antibody response in vitro.

1984 • 51 citations

Platelet-induced neurogenic coronary contractions due to accumulation of the false neurotransmitter, 5-hydroxytryptamine.

1985 • 50 citations

Sympathetic immunoregulation: difference between high- and low-responder animals

1982 • 49 citations

Role of alpha adrenoceptor activation in modulating the murine primary antibody response in vitro.

1985 • 49 citations

Catechol-O-methyltransferase activity and aminergic binding sites distribution in human peripheral blood lymphocyte subpopulations

1983 • 48 citations

Effect of catecholamines on lymphopoiesis in fetal mouse thymic explants.

1979 • 45 citations

Developmental plasticity of central noradrenaline neurons after neonatal damage—changes in transmitter functions

1979 • 45 citations

Noradrenergic Sympathetic Innervation of Spleen and Lymph Nodes in Relation to Specific Cellular Compartments

1986 • 44 citations

Adrenergic receptors on monocytes modulate complement component synthesis.

1982 • 44 citations

Different numbers of β-receptors in human lymphocyte subpopulations

1982 • 40 citations

Influence of adrenaline on the dissemination of antibody-producing cells from the spleen.

1975 • 39 citations

Histotopography of catecholamines in the mammalian thymus

1974 • 35 citations

The innervation of the spleen

1944 • 35 citations

Cyclic Nucleotides in Lymphocyte Proliferation and Differentiation

1977 • 35 citations

Electron microscopic studies of the innervation of the human spleen

1977 • 34 citations

Catecholamine-containing neurons and lymphoid cells in a lacrimal gland of the pigeon

1985 • 34 citations

Characteristics of Adrenergic Binding Sites Associated with Murine Lymphocytes Isolated from Spleen

1980 • 34 citations

�ber die mikroskopische Innervation der Milz

1929 • 30 citations

Sympathetic innervation of fetal mouse thymus

1984 • 30 citations

Noradrenergic sympathetic innervation of the spleen: V. Acute drug‐induced depletion of lymphocytes in the target fields of innervation results in redistribution of noradrenergic fibers but maintenance of compartmentation

1987 • 28 citations

Bone marrow response to stimulation of the sympathetic trunks in rats

1970 • 28 citations

Studies of the hemopoietic microenvironment

1977 • 27 citations

Possibilities of a direct adrenergic influence on blood elements in the dog spleen.

1973 • 26 citations

Evidence for Local Neuromodulation of T Cell Migration in Vivo

1958 • 21 citations

beta-Adrenergic receptors and adenylate cyclase activity in murine lymphoid cell lines.

1985 • 12 citations