Participation of C3 and its Ligands in Complement Activation

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Proteases and biological control

1976 • 1,380 citations

The Properdin System and Immunity: I. Demonstration and Isolation of a New Serum Protein, Properdin, and Its Role in Immune Phenomena

1954 • 940 citations

MOLECULAR ORGANIZATION AND FUNCTION OF THE COMPLEMENT SYSTEM

1988 • 831 citations

The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

1986 • 575 citations

Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.

1975 • 474 citations

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B

1984 • 433 citations

Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3.

1981 • 426 citations

The structural basis of the multiple forms of human complement component C4

1984 • 419 citations

Regulation by membrane sialic acid of β1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway

1978 • 415 citations

Proteases and biological control

1975 • 412 citations

Human complement component C3: cDNA coding sequence and derived primary structure.

1985 • 410 citations

Molecular Biology and Chemistry of the Alternative Pathway of Complement

1980 • 409 citations

Adipsin: A Circulating Serine Protease Homolog Secreted by Adipose Tissue and Sciatic Nerve

1987 • 398 citations

Evidence for presence of an internal thiolester bond in third component of human complement.

1980 • 368 citations

THE PROPERDIN SYSTEM AND IMMUNITY

1956 • 363 citations

Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.

1987 • 351 citations

Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and beta1 H for cell-bound C3b.

1979 • 339 citations

Relation of putative thioester bond in C3 to activation of the alternative pathway and the binding of C3b to biological targets of complement.

1980 • 328 citations

Complete amino acid sequence of human plasma beta 2-glycoprotein I.

1984 • 326 citations

The covalent-binding reaction of complement component C3

1981 • 304 citations

Adipsin and Complement Factor D Activity: An Immune-Related Defect in Obesity

1989 • 303 citations

A comparison of the properties of two classes, C4A and C4B, of the human complement component C4.

1984 • 296 citations

Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity.

1982 • 296 citations

The alternative pathway of complement

1984 • 294 citations

Complement Ligand-Receptor Interactions that Mediate Biological Responses

1983 • 294 citations

Activation of the alternative complement pathway due to resistance of zymosan-bound.

1977 • 283 citations

The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.

1988 • 281 citations

cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.

1987 • 277 citations

Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins.

1987 • 267 citations

Human Alternative Complement Pathway: Membrane-Associated Sialic Acid Regulates the Competition between B and β1H for Cell-Bound C3b

1979 • 257 citations

Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis.

1987 • 237 citations

The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.

1984 • 237 citations

Capsular sialic acid prevents activation of the alternative complement pathway by type III, group B streptococci.

1982 • 210 citations

Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway.

1976 • 204 citations

Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen.

1984 • 202 citations

The structure of human complement component C7 and the C5b-7 complex.

1988 • 199 citations

Complement system proteins which interact with C3b or C4b A superfamily of structurally related proteins

1986 • 195 citations

Mechanism of action of factor D of the alternative complement pathway.

1978 • 191 citations

Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs

1988 • 189 citations

ENHANCEMENT OF THE HEMOLYTIC ACTIVITY OF THE SECOND COMPONENT OF HUMAN COMPLEMENT BY OXIDATION

1967 • 189 citations

Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties

1981 • 184 citations

Covalent binding and hemolytic activity of complement proteins.

1980 • 183 citations

The Alternative Pathway of Complement Activation

1976 • 180 citations

The genealogy of some recently evolved vertebrate proteins

1985 • 179 citations

Structure, Organization, and Regulation of the Complement Genes

1988 • 178 citations

Activation of the alternative complement pathway with rabbit erythrocytes by circumvention of the regulatory action of endogenous control proteins

1977 • 178 citations

Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9.

1984 • 160 citations

Activation of the First Component of Complement

1987 • 160 citations

The alternate pathway of complement activation. The role of C3 and its inactivator (KAF).

1973 • 153 citations

Generation of three different fragments of bound C3 with purified factor I or serum. II. Location of binding sites in the C3 Fragments for Factors B and H, complement receptors , and bovine conglutinin

1983 • 151 citations

A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue.

1985 • 149 citations

Primary structure of human complement component C2 Homology to two unrelated protein families

1986 • 148 citations

Complete primary structure for the zymogen of human complement factor B.

1984 • 142 citations

Molecular architecture of human properdin, a positive regulator of the alternative pathway of complement.

1984 • 131 citations

Human α2-macroglobulin: structure and function

1982 • 130 citations

A new function of the activated third component of complement: binding to C5, an essential step for C5 activation.

1978 • 126 citations

Renal Filtration and Catabolism of Complement Protein D

1985 • 118 citations

Analysis of the natural polymeric forms of human properdin and their functions in complement activation.

1989 • 118 citations

PROPERDIN FACTOR D: CHARACTERIZATION OF ITS ACTIVE SITE AND ISOLATION OF THE PRECURSOR FORM

1974 • 117 citations

Metabolism of complement factor D in renal failure

1988 • 115 citations

Cleavage of C2 by C1̄s̄ into the antigenically distinct fragments C2a and C2b: Demonstration of binding of C2b to C4b

1977 • 112 citations

Complementary DNA and derived amino acid sequence of the .alpha. subunit of human complement protein C8: evidence for the existence of a separate .alpha. subunit messenger RNA

1987 • 112 citations

The human complement system: assembly of the classical pathway C3 convertase

1980 • 112 citations

C3 Requirements for Formation of Alternative Pathway C5 Convertase

1976 • 110 citations

A Previously Undetected MHC Gene with an Unusual Periodic Structure

1988 • 108 citations

The binding of human complement proteins C5, factor B, β1H and properdin to complement fragment C3b on zymosan

1981 • 107 citations

Complementary DNA and derived amino acid sequence of the .beta. subunit of human complement protein C8: identification of a close structural and ancestral relationship to the .alpha. subunit and C9

1987 • 106 citations

Isolation of complement-fragment-iC3b-binding proteins by affinity chromatography. The identification of p150,95 as an iC3b-binding protein

1985 • 106 citations

C5 convertase of the alternative complement pathway: covalent linkage between two C3b molecules within the trimolecular complex enzyme.

1988 • 105 citations

Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r

1986 • 100 citations

Mapping of distinct von Willebrand factor domains interacting with platelet GPIb and GPIIb/IIIa and with collagen using monoclonal antibodies

1986 • 93 citations

Covalent association of C3b with C4b within C5 convertase of the classical complement pathway.

1987 • 90 citations

MHC Class III products: an electron microscopic study of the C3 convertases of human complement.

1984 • 81 citations

Third component of human complement: Localization of the internal thiolester bond

1982 • 80 citations

Disulfide bonds are localized within the short consensus repeat units of complement regulatory proteins: C4b-binding protein

1989 • 77 citations

Structural characterization of factor I mediated cleavage of the third component of complement

1982 • 77 citations

Release of soluble immune complexes from immune adherence receptors on human erythrocytes is mediated by C3b inactivator independently of β1H and is accompanied by generation of C3c

1982 • 72 citations

The purification and properties of the second component of guinea-pig complement

1982 • 72 citations

Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates.

1987 • 71 citations

The Classical Complement Pathway: Mechanism of Activation of the First Component by Antigen-Antibody Complexes (Part 1 of 3)

1982 • 65 citations

Primary structure of the fifth component of murine complement

1987 • 65 citations

Ultrastructure of cobra venom factor-dependent C3/C5 convertase and its zymogen, factor B of human complement.

1982 • 64 citations

The structure and function of the third component of human complement—I. The nature and extent of conformational changes accompanying C3 activation

1981 • 64 citations

TheFactor BandC2genes

1984 • 62 citations

Alternative complement pathway activation fragment Ba binds to C3b. Evidence that formation of the factor B-C3b complex involves two discrete points of contact.

1987 • 61 citations

Identification of functionally relevant determinants on the complement component C3 with monoclonal antibodies.

1982 • 57 citations

Restriction of alternative complement pathway activation by sialosylglycolipids

1982 • 57 citations

C3 convertase of the alternative complement pathway. Demonstration of an active, stable C3b, Bb (Ni) complex.

1983 • 55 citations

Isolation and characterization of a 33,000-dalton fragment of complement Factor B with catalytic and C3b binding activity.

1984 • 55 citations

Probing functional sites on complement protein B with monoclonal antibodies. Evidence for C3b-binding sites on Ba.

1987 • 55 citations

The interaction of C5 with C3b in free solution: a sufficient condition for cleavage by a fluid phase C3/C5 convertase.

1980 • 54 citations

Amino acid sequence studies of human properdin—N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with trypsin and the peptides produced by cyanogen bromide treatment

1981 • 53 citations

Studies on the sub-unit structure of human properdin

1974 • 53 citations

A novel cleavage product of human complement component C3 with structural and functional properties of cobra venom factor.

1988 • 53 citations

cDNA cloning and expression of human complement component C2.

1989 • 52 citations

Carbohydrate composition of the second, third and fifth components and factors B and D of human complement

1985 • 51 citations

A 34-amino acid peptide of the third component of complement mediates properdin binding.

1988 • 50 citations

Human α2macroglobulin

1984 • 49 citations

Native and activated properdin: interconvertibility and identity of amino- and carboxy-terminal sequences.

1980 • 44 citations

Amino acid sequence of human D of the alternative complement pathway

1984 • 41 citations

Localization of the human MHC-linked complement genes between HLA-B and HLA-DR by using HLA mutant cell lines.

1985 • 40 citations

Multiple sedimenting species of properdin in human serum and interaction of purified properdin with the third component of complement.

1976 • 40 citations

Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complement

1988 • 40 citations

Activation of C1

1984 • 39 citations

Quantitation of complement factor D in human serum by a solid-phase radioimmunoassay

1984 • 39 citations

Post-translational modification of the fourth component of complement. Effect of tunicamycin and amino acid analogs on the formation of the internal thiol ester and disulfide bonds.

1983 • 36 citations

Residual hemolytic and proteolytic activity expressed by Bb after decay-dissociation of C3b,Bb.

1984 • 36 citations

The human complement system

1975 • 36 citations

The Structure and Genetics of the C2 and Factor B Genes

1985 • 35 citations

The Year in immunology

1982 • 34 citations

In vitro biosynthesis of complement protein D by U937 cells.

1985 • 34 citations

The reaction of iodine and thiol-blocking reagents with human complement components C2 and factor B. Purification and N-terminal amino acid sequence of a peptide from C2a containing a free thiol group

1983 • 30 citations

Evidence for a C4b binding site on the C2b domain of C2.

1988 • 27 citations

Properdin is a trimer

1982 • 25 citations

The Alternative Pathway of Complement

1985 • 25 citations

Isolation of complement protein D from urine of patients with Fanconi's syndrome

1987 • 24 citations

Partial amino acid sequence of human factor D:homology with serine proteases.

1980 • 23 citations

Amino acid sequence of human factor D of the complement system

1984 • 22 citations

Cloning of cDNA and Genomic DNA for Human von Willebrand Factor

1986 • 22 citations

A thermodynamic study of the interaction between human complement components C3b or C3(H2O) and factor B in solution.

1988 • 21 citations

Human complement protein D catabolism by the rat kidney.

1986 • 20 citations

Biosynthesis of the Internal Thioester Bond of the Third Component of Complement1

1984 • 16 citations

Active site amino acid sequence of human factor D.

1980 • 14 citations

Biosynthesis of complement protein D by HepG2 cells: a comparison of D produced by HepG2 cells, U937 cells and blood monocytes

1985 • 13 citations

ヒト,プロパージンのアミノ酸配列 トリプシンでの限定たんぱく質分解により生成した分画や,臭化シアンにより生成されたペプチドの配列やN末端分析

1981 • 11 citations

Structure, molecular genetics, and function of complement control proteins: an update.

1988 • 3 citations