Modulation of neurotransmission by purine nucleotides and nucleosides

Handbook of Psychopharmacology

1988 • 2,778 citations

Regulation of noradrenaline release by presynaptic receptor systems

1977 • 1,482 citations

The role of calcium in neuromuscular facilitation

1968 • 1,331 citations

SIXTH GADDUM MEMORIAL LECTURE NATIONAL INSTITUTE FOR MEDICAL RESEARCH, MILL HILL, JANUARY 1977

1977 • 935 citations

Do some nerve cells release more than one transmitter?

1976 • 633 citations

Are methylxanthine effects due to antagonism of endogenous adenosine?

1979 • 419 citations

Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides

1979 • 402 citations

The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat

1972 • 366 citations

Adenosine as inhibitor of myocardial effects of catecholamines

1977 • 364 citations

Basic Mechanisms of Prostaglandin Action on Autonomic Neurotransmission

1977 • 330 citations

Alkylxanthines: Inhibition of adenosine-elicited accumulation of cyclic AMP in brain slices and of brain phosphodiesterase activity

1979 • 311 citations

Cyclic Nucleotides in the Nervous System

1977 • 297 citations

Effects of adenosine on adrenergic neurotransmission; Prejunctional inhibition and postjunctional enhancement

1976 • 288 citations

The inhibitory effect of adenosine and related nucleotides on the release of acetylcholine

1976 • 252 citations

Adenosine inhibits the accumulation of cyclic AMP in cultured brain cells

1978 • 251 citations

Presynaptic receptors

1978 • 243 citations

Physiological and regulatory functions of adenosine and adenine nucleotides

1980 • 228 citations

The Release of Catecholamines from Adrenergic Neurons

1979 • 218 citations

Direct evidence for ATP release from non-adrenergic, non-cholinergic (“purinergic”) nerves in the guinea-pig taenia coli and bladder

1978 • 216 citations

Stimulation of Prostaglandin Biosynthesis by Adenine Nucleotides

1974 • 211 citations

Effects of adenosine on depolarization-induced release of various radiolabelled neurotransmitters from slices of rat corpus striatum

1979 • 210 citations

Inhibition of acetylcholine release from cholinergic nerves by adenosine, adenine nucleotides and morphine: antagonism by theophylline.

1976 • 209 citations

[ ³ H]Adenosine Triphosphate: Release during Stimulation of Enteric Nerves

1971 • 204 citations

The biogenesis of adrenal chromaffin granules

1977 • 203 citations

Release of adenosine triphosphate from isolated adult heart cells in response to hypoxia

1977 • 201 citations

Biological Sciences: Release of ATP from Rat Motor Nerve Terminals

1973 • 201 citations

Metabolism of [14C]adenine and derivatives by cerebral tissues, superfused and electrically stimulated

1972 • 193 citations

THE EFFECTS OF ADENOSINE TRIPHOSPHATE AND ADENOSINE DIPHOSPHATE ON TRANSMISSION AT THE RAT AND FROG NEUROMUSCULAR JUNCTIONS

1975 • 191 citations

The postjunctional effects and neural release of purine compounds in the guinea-pig vas deferens

1978 • 187 citations

Inhibition of sympathetic neurotransmission in canine blood vessels by adenosine and adenine nucleotides.

1977 • 175 citations

RELEASE OF ATP FROM A SYNAPTOSOMAL PREPARATION BY ELEVATED EXTRACELLULAR K⁺ AND BY VERATRIDINE

1978 • 173 citations

The Role of Cyclic Nucleotides in the CNS

1977 • 163 citations

Reflex activation of sympathetic pathways to vesical smooth muscle and parasympathetic ganglia by electrical stimulation of vesical afferents.

1976 • 162 citations

Adenosine modulation of synaptosomal dopamine release

1979 • 158 citations

Adenosine as a putative transmitter in the cerebral cortex. Studies with potentiators and antagonists

1975 • 158 citations

Adenosine modulates depolarization-induced release of 3H-noradrenaline from slices of rat brain neocortex

1978 • 154 citations

UPTAKE AND RELEASE OF [¹⁴C]ADENINE DERIVATIVES AT BEDS OF MAMMALIAN CORTICAL SYNAPTOSOMES IN A SUPERFUSION SYSTEM

1974 • 153 citations

Outflux of various phosphates during membrane depolarization of excitable tissues

1962 • 147 citations

Presynaptic inhibitory actions of adenine nucleotides and adenosine on neurotransmission in the rat vas deferens

1977 • 145 citations

ACCUMULATION OF CYCLIC ADENOSINE 3′, 5′‐MONOPHOSPHATE IN CEREBRAL CORTICAL SLICES FROM RAT AND MOUSE: STIMULATORY EFFECT OF α‐ AND β‐ADRENERGIC AGENTS AND ADENOSINE

1973 • 144 citations

Inhibition of noradrenaline release by adenosine.

1978 • 138 citations

Stimulation-dependent release of 3H-adenosine derivatives from central axon terminals to target neurones

1976 • 136 citations

Adenosine and adenosine triphosphate decrease 45Ca uptake by synaptosomes stimulated by potassium

1979 • 124 citations

DEPRESSION OF EVOKED POTENTIALS IN BRAIN SLICES BY ADENOSINE COMPOUNDS

1978 • 124 citations

Modulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATP

1979 • 119 citations

Dopaminergic Ergot Derivatives and Motor Function

1979 • 118 citations

Antagonistic effects of theophylline and adenosine on adrenergic neuroeffector transmission in the rabbit kidney.

1978 • 116 citations

Neurogenic release of purine compounds in blood vessels.

1975 • 108 citations

On the relation between ATP splitting and secretion in the adrenal chromaffin cell: extrusion of ATP (unhydrolysed) during release of catecholamines

1966 • 107 citations

Inhibitory effect of adenosine on adrenergic neuroeffector transmission in the rabbit heart

1979 • 106 citations

Possible feed-back inhibition of noradrenaline release by purine compounds

1977 • 104 citations

Microiontophoretic studies of the effects of cyclic nucleotides on excitability of neurones in the rat cerebral cortex

1977 • 100 citations

Concomitant changes in cyclic AMP level and postsynaptic potentials of olfactory cortex slices induced by adenosine derivatives

1976 • 97 citations

Secretory Processes in the Mammalian Pinealocyte under Natural and Experimental Conditions

1979 • 96 citations

Axonal transport of adenosine and uridine derivatives and transfer to postsynaptic neurons

1974 • 92 citations

Effects of purine compounds on cholinergic nerves. Specificity of adenosine and related compounds on acetylcholine release in electrically stimulated guinea pig ileum

1978 • 90 citations

Effects of adenosine analogs on rat cerebral cortical neurons

1976 • 89 citations

Effect of theophylline and other drugs on rabbit renal cyclic nucleotide phosphodiesterase, 5′-nucleotidase and adenosine deaminase

1978 • 88 citations

The release of 3H-adenosine and its derivatives from cat sensorimotor cortex

1975 • 88 citations

Turnover of adenine nucleotides in cholinergic synaptic vesicles of the Torpedo electric organ

1978 • 87 citations

Distribution and release of adenosine triphosphate in rat brain

1978 • 84 citations

Purine salvage at the cholinergic nerve endings of the Torpedo electric organ: The central role of adenosine

1979 • 83 citations

Effects of Adenine Nucleotides on the Contractility and Membrane Potentials of Rat Atrium

1957 • 82 citations

Release of Adenosine‐like Material from Isolated Perfused Dog Adipose Tissue Following Sympathetic Nerve Stimulation and its Inhibition by Adrenergic α‐Receptor Blockade

1976 • 81 citations

Purine nucleoside and nucleotide interactions on normal and subsensitive alpha adrenoreceptor responsiveness in guinea-pig vas deferens.

1978 • 81 citations

EVIDENCE FOR PURINERGIC INNERVATION OF THE ANOCOCCYGEUS MUSCLE

1978 • 79 citations

Release of ATP from stimulated nerve electroplaque junctions

1975 • 78 citations

Release of ³H‐nucleosides from ³H‐adenine labelled hypothalamic synaptosomes

1979 • 73 citations

Inhibition of acetylcholine release in guinea pig ileum by adenosine

1978 • 72 citations

RELEASE OF ³H‐PURINES FROM [³H]‐ADENINE LABELLED RABBIT KIDNEY FOLLOWING SYMPATHETIC NERVE STIMULATION, AND ITS INHIBITION BY α‐ADRENOCEPTOR BLOCKADE

1978 • 69 citations

Presynaptic inhibitory actions of 2-substituted adenosine derivatives on neurotransmission in rat vas deferens: Effects of inhibitors of adenosine uptake and deamination

1979 • 67 citations

Effect of Acetylcholine and Adenosine on Cardiac Cellular Potentials

1956 • 64 citations

Are vesicles necessary for release of acetylcholine at cholinergic synapses?

1979 • 63 citations

Specific binding of 3H-adenosine to rat brain membranes

1979 • 57 citations

RELATED CHANGES IN AMOUNTS OF ACh AND ATP IN RESTING AND ACTIVE TORPEDO NERVE ELECTROPLAQUE SYNAPSES

1977 • 56 citations

The role of calcium in the regulation of cyclic nucleotide levels in brain slices of rat and guinea pig

1978 • 56 citations

Adenosine as a constituent of the brain and of isolated cerebral tissues, and its relationship to the generation of adenosine 3′:5′-cyclic monophosphate

1977 • 56 citations

Evidence that most noradrenaline is stored without ATP in sympathetic large dense core nerve vesicles

1974 • 55 citations

Cyclic nucleotides in the nervous system

1978 • 52 citations

Quantitative studies of the release of purine compounds following stimulation of non-adrenergic inhibitory nerves in the stomach

1971 • 51 citations

Inhibitory action of adenosine, 5-HT (serotonin) and GABA (γ-aminobutyric acid) on the postsynaptic potential (PSP) of slices from olfactory cortex and superior colliculus in correlation to the level of cyclic AMP

1979 • 49 citations

EFFECT OF N6, 2'-O-DIBUTYRYL 3'5'-CYCLIC ADENOSINE MONOPHOSPHATE, 3', 5', -CYCLIC ADENOSINE MONOPHOSPHATE AND ADENOSINE TRIPHOSPHATE ON ACETYLCHOLINE OUTPUT FROM CHOLINERGIC NERVES IN GUINEA PIG ILEUM

1972 • 47 citations

INHIBITION OF 5′‐NUCLEOTIDASE IN RAT BRAIN BY METHYLXANTHINES

1975 • 45 citations

On the Possible Role of Adenosine as a Modulatory Messenger in the Hippocampus and other Regions of the CNS

1979 • 44 citations

Vascular and Metabolic Effects of Theophylline, Dibuturyl Cyclic AMP and Dibuturyl Cyclic GMP in Canine Subcutaneous Adipose Tissue in situ¹

1974 • 41 citations

A role of cyclic nucleotides in neuromuscular transmission.

1976 • 40 citations

Effects of inhibitors and adenosine on (HCO3−/CO2)-stimulated swelling and Cl− uptake in brain slices and cultured astrocytes

1978 • 40 citations

The accumulation of cyclic AMP and cyclic GMP in guinea pig brain slices

1977 • 40 citations

Electron-dense Particle in Cholinergic Synaptic Vesicles

1973 • 40 citations

The actions of adenosine and various nucleosides and nucleotides on the isolated toad spinal cord

1978 • 37 citations

Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. II. Effects of papaverine.

1974 • 37 citations

Effects of methylxanthines and imidazole on hte contractions of guinea-pig ileum induced by transmural stimulation

1976 • 36 citations

Catecholamines and adenine nucleotide material in effluent from stimulated adrenal medulla and spleen

1970 • 35 citations

Release of [14C]adenosine derivatives from superfused synaptosome preparations. Effects of depolarizing agents and metabolic inhibitors

1980 • 34 citations

STIMULATION OF GLYCOGENOLYSIS IN RAT CAUDATE NUCLEUS SLICES BY <scp>L</scp>‐ISOPROPYLNOREPINEPHERINE, DIBUTYRYL CYCLIC AMP AND 2‐CHLOROADENOSINE

1976 • 33 citations

Adenine mononucleotides and their metabolites liberated from and applied to isolated tissues of the mammalian brain

1977 • 32 citations

Potentiation by dipyridamole of the inhibition of guinea-pig ileum twitch response caused by adenine derivatives.

1978 • 31 citations

Adenosine effects upon transmitter release parameters in the Mg2+-paralyzed neuro-muscular junction of frog

1979 • 30 citations

Relative importance of calcium and cyclic AMP for noradrenaline secretion from sympathetic nerves of guinea-pig vas deferens and for prostaglandine-induced depression of noradrenaline secretion

1976 • 29 citations

[³H]‐adenine nucleotide and [³H]‐noradrenaline release evoked by electrical field stimulation, perivascular nerve stimulation and nicotine from the taenia of the guinea‐pig caecum

1973 • 29 citations

Release of radioactive purines from cat nictitating membrane labeled with 3H-adenine

1979 • 28 citations

Axonal release and transfer of nucleoside derivates in the entorhinal-hippocampal system: An autoradiographic study

1977 • 25 citations

ACTIVATION OF GLYCOGEN PHOSPHORYLASE IN RAT CAUDATE NUCLEUS SLICES BY l-ISOPROPYLNOREPINEPHERINE AND DIBUTYRYL CYCLIC AMP

1977 • 24 citations

THE DEVELOPMENT OF TACHYPHYLAXIS TO ELECTRICAL STIMULATION IN GUINEA‐PIG ILEAL LONGITUDINAL MUSCLES AND THE POSSIBLE PARTICIPATION OF ADENOSINE AND ADENINE NUCLEOTIDES

1978 • 23 citations

Efflux of Cyclic Nucleotides from Rat Pineal: Release of Guanosine 3′,5′-Monophosphate from Sympathetic Nerve Endings

1977 • 23 citations

Phosphate efflux and oxygen consumption in small non‐myelinated nerve fibres at rest and during activity

1979 • 19 citations

Elevation of guanosine 3′,5′-monophosphate level by adenosine in cerebellar slices of guinea pig

1977 • 19 citations

The effects of adenosine and adenine nucleotides on the guinea-pig vas deferens: Evidence for existence of purinergic receptors

1979 • 19 citations

Depolarization and potentiation of responses to acetycholine elicited by ATP on frog muscle

1975 • 18 citations

Effects of adenosine on neurally mediated norepinephrine release from the cat spleen

1979 • 17 citations

Is presynaptic acetylcholine release accompanied by the secretion of the synaptic vesicles contents?

1978 • 17 citations

Release of adenosine from the rabbit heart by sympathetic nerve stimulation

1979 • 16 citations

Increase in efflux of inorganic phosphate during electrical activity in small non‐myelinated nerve fibres.

1978 • 16 citations

Adenosine‐sensitive adenylate cyclase in rat striatal homogenates

1977 • 15 citations

Adenosine and related compounds do not affect nerve terminal excitability in rat CNS

1980 • 13 citations

Effects of adenosine triphosphate and prostaglandins on vascular adrenergic transmission.

1978 • 13 citations

Effect of muscarinic agonists on the release of [3H]noradrenaline from the guinea-pig perfused heart

1974 • 11 citations

Uptake and release of phosphate and calcium in nervous tissue

1979 • 11 citations

Control of cyclic adenosine 3':5'-monophosphate-elevating effect of adenosine in C-1300 murine neuroblastoma in tissue culture.

1977 • 6 citations