Alzheimer’s presenilin 1 modulates sorting of APP and its carboxyl‐terminal fragments in cerebral neurons in vivo

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 • 1,880 citations

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 • 1,467 citations

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

1992 • 1,453 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

2007 • 1,114 citations

Reconstitution of γ-secretase activity

2003 • 868 citations

The role of presenilin cofactors in the γ-secretase complex

2003 • 856 citations

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

2003 • 744 citations

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

1994 • 494 citations

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

1999 • 483 citations

Model‐guided microarray implicates the retromer complex in Alzheimer's disease

2005 • 413 citations

The role of cerebral amyloid β accumulation in common forms of Alzheimer disease

2005 • 387 citations

Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons

1998 • 356 citations

Protein Kinase C-dependent α-Secretase Competes with β-Secretase for Cleavage of Amyloid-β Precursor Protein in the Trans-Golgi Network

2000 • 320 citations

Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis

2006 • 320 citations

Loss of Apolipoprotein E Receptor LR11 in Alzheimer Disease

2004 • 312 citations

Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production

2005 • 277 citations

Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis

2004 • 207 citations

Endocytic Trafficking Routes of Wild Type and ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator

2004 • 206 citations

Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane

2002 • 191 citations

Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein

1994 • 175 citations

Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism

2006 • 137 citations

Presenilin-1 Regulates Intracellular Trafficking and Cell Surface Delivery of β-Amyloid Precursor Protein

2003 • 136 citations

Nicastrin Is Critical for Stability and Trafficking but Not Association of Other Presenilin/γ-Secretase Components

2005 • 114 citations

Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells

1993 • 112 citations

Phospholipase D1 corrects impaired βAPP trafficking and neurite outgrowth in familial Alzheimer’s disease-linked presenilin-1 mutant neurons

2006 • 105 citations

Calpain Activity Regulates the Cell Surface Distribution of Amyloid Precursor Protein

2002 • 105 citations

Expression of APP in transgenic mice: a Comparison of neuron-specific promoters

1996 • 94 citations

Regulation of tyrosinase trafficking and processing by presenilins: Partial loss of function by familial Alzheimer's disease mutation

2005 • 90 citations

Alzheimer Amyloid Protein Precursor Is Localized in Nerve Terminal Preparations to Rab5-containing Vesicular Organelles Distinct from Those Implicated in the Synaptic Vesicle Pathway

1996 • 83 citations

A Role for Presenilin 1 in Regulating the Delivery of Amyloid Precursor Protein to the Cell Surface

2002 • 73 citations

Carboxyl-terminal Fragments of Alzheimer β-Amyloid Precursor Protein Accumulate in Restricted and Unpredicted Intracellular Compartments in Presenilin 1-deficient Cells

2000 • 73 citations

Presenilin/γ‐secretase activity regulates protein clearance from the endocytic recycling compartment

2006 • 60 citations

Presenilins and γ-Secretase Inhibitors Affect Intracellular Trafficking and Cell Surface Localization of the γ-Secretase Complex Components

2004 • 46 citations

Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity

2004 • 38 citations

Lipid homoeostasis and Golgi secretory function

2006 • 30 citations

Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis

2005 • 26 citations

Presenilin‐1‐mediated Retention of APP Derivatives in Early Biosynthetic Compartments

2006 • 24 citations

Expression of the Thy-1 gene and Thy-1-derived fusion genes in transgenic mice.

1989 • 4 citations