Autoimmunity, Apoptosis Defects and Retroviruses

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Amino Acid Homology Between the Encephalitogenic Site of Myelin Basic Protein and Virus: Mechanism for Autoimmunity

1985 • 941 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

1992 • 857 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily

1990 • 614 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Inhibition of Lymphocyte Proliferation by a Synthetic Peptide Homologous to Retroviral Envelope Proteins

1985 • 433 citations

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

1987 • 413 citations

Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

1989 • 385 citations

Inactivation of muscle chloride channel by transposon insertion in myotonic mice

1991 • 382 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletion

1988 • 372 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.

1992 • 339 citations

Exocrinopathy resembling Sjögren's syndrome in HTLV-1 tax transgenic mice

1989 • 335 citations

A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen

1987 • 312 citations

Soluble cytokine receptors: their role in immunoregulation

1991 • 289 citations

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

1993 • 287 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Identification of homologous regions in human immunodeficiency virus I gp41 and human MHC class II beta 1 domain. I. Monoclonal antibodies against the gp41-derived peptide and patients' sera react with native HLA class II antigens, suggesting a role for autoimmunity in the pathogenesis of acquired immune deficiency syndrome.

1988 • 268 citations

AUTOANTIBODIES ARE ANTI-IDIOTYPE ANTIBODIES TO ANTIVIRAL ANTIBODIES

1983 • 257 citations

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

1992 • 242 citations

Mls — a retrovirus exploits the immune system

1991 • 233 citations

Detection of serum antibodies to retroviral proteins in patients with primary sjögren's syndrome (autoimmune exocrinopathy)

1990 • 224 citations

Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome.

1989 • 209 citations

A Virus-Encoded "Superantigen" in a Retrovirus-Induced Immunodeficiency Syndrome of Mice

1991 • 198 citations

Common epitope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I infected individuals.

1990 • 197 citations

The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1.

1990 • 189 citations

Evolutionarily conserved Ets family members display distinct DNA binding specificities.

1992 • 175 citations

A conserved idiotype and antibodies to retroviral proteins in systemic lupus erythematosus.

1990 • 166 citations

Common epitope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I-infected individuals.

1989 • 151 citations

Cytokine modulation of HIV expression

1993 • 147 citations

Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.

1994 • 145 citations

Determination of an epitope of the diffuse systemic sclerosis marker antigen DNA topoisomerase I: sequence similarity with retroviral p30gag protein suggests a possible cause for autoimmunity in systemic sclerosis.

1989 • 132 citations

Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide)

1992 • 121 citations

Inhibition of lymphoproliferation by a synthetic peptide with sequence identity to gp41 of human immunodeficiency virus type 1

1989 • 117 citations

A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells

1992 • 113 citations

Macrophage accumulation in mice is inhibited by low molecular weight products from murine leukemia viruses.

1980 • 110 citations

Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E.

1987 • 106 citations

Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse.

1993 • 98 citations

Increased synthesis and expression of H-2 antigens on thymocytes as a result of radiation leukemia virus infection: a possible mechanism for H-2 linked control of virus-induced neoplasia.

1978 • 95 citations

Direct and indirect mechanisms mediating apoptosis during HIV infection: contribution to in vivo CD4 T cell depletion

1993 • 91 citations

Genes Newly Identified as Regulated by Glucocorticoids in Murine Thymocytes

1991 • 91 citations

A role for endogenous retroviral sequences in the regulation of lymphocyte activation.

1989 • 90 citations

Early Deletion and Late Positive Selection of T-Cells Expressing a Male-Specific Receptor in T-Cell Receptor Transgenic Mice

1989 • 83 citations

Identification, using synthetic peptides, of the minimum amino acid sequence from the retroviral transmembrane protein p15E required for inhibition of lymphoproliferation and its similarity to gp21 of human T-lymphotropic virus types I and II

1989 • 70 citations

Transgenic rearranged T cell receptor gene inhibits lymphadenopathy and accumulation of CD4-CD8-B220+ T cells in lpr/lpr mice.

1990 • 64 citations

Sphingolipids and cell function

1992 • 63 citations

A variable number of tandem repeats locus within the human complement C2 gene is associated with a retroposon derived from a human endogenous retrovirus.

1992 • 61 citations

Human retrovirus-related synthetic peptides inhibit T lymphocyte proliferation

1988 • 59 citations

Inhibition of human lymphocyte mitogen and antigen response by a 15,000-dalton protein from feline leukemia virus.

1979 • 54 citations

Concise Communications

1991 • 52 citations

Glucose induces intracisternal type A retroviral gene transcription and translation in pancreatic beta cells.

1986 • 48 citations

Cross-reactivity of the subunit of the Sm ribonucleoprotein autoantigen with proline-rich polypeptides

1992 • 38 citations

Retrovirus-mediated immunosuppression. II. FeLV-UV alters in vitro murine T lymphocyte behavior by reversibly impairing lymphokine secretion.

1985 • 38 citations

The acute retroviral syndrome and the pathogenesis of HIV-1 infection

1993 • 37 citations

Inhibition of cellular DNA synthesis by reovirus occurs through a receptor-linked signaling pathway that is mimicked by antiidiotypic, antireceptor antibody.

1989 • 35 citations

Demonstration of two distinct forms of released low‐affinity type interleukin 2 receptors

1988 • 34 citations

Murine retroviruses control class I major histocompatibility antigen gene expression via a trans effect at the transcriptional level.

1987 • 34 citations

Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction.

1989 • 33 citations

Interruption of two immunoglobulin heavy-chain switch regions in murine plasmacytoma P3.26Bu4 by insertion of retroviruslike element ETn.

1987 • 27 citations

Recombinant hydrophilic region of murine retroviral protein p15E inhibits stimulated T-lymphocyte proliferation.

1987 • 25 citations

Association of murine lupus and thymic full-length endogenous retroviral expression maps to a bone marrow stem cell.

1991 • 21 citations

Evidence for possible retroviral involvement in autoimmune diseases.

1992 • 20 citations

Genetics and expression of the Q6 and Q8 genes. An LTR-like sequence in the 3? untranslated region

1989 • 19 citations

Endogenous Mtv-8 or a closely linked sequence stimulates rearrangement of the downstream V kappa 9 gene.

1992 • 17 citations

Integration of the transposon-like element ETn upstream of V lambda 2 in the cell line P3X63Ag8.

1989 • 14 citations

Non-cytolytic control of HIV replication by CD8+ T cells

1993 • 12 citations

Molecular Aspects of Systemic Lupus Erythematosus: Murine Endogenous Retroviral Expression

1992 • 8 citations

Non-H-2 histocompatibility antigens encoded by Moloney-murine leukemia virus in Mov mouse strains are detectable by skin grafting and cytolytic T lymphocytes.

1988 • 6 citations