Macromolecular Sites for Specific Neurotoxins and Drugs on Chemosensitive Synapses and Electrical Excitation in Biological Membranes

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

The Hydrophobic Effect: Formation of Micelles and Biological Membranes

1991 • 3,370 citations

The Hydrophobic Effect: Formation of Micelles and Biological Membranes

1981 • 2,803 citations

Single-Channel Recording

1995 • 2,565 citations

Single-channel currents recorded from membrane of denervated frog muscle fibres

1976 • 2,456 citations

Measurement of current‐voltage relations in the membrane of the giant axon of Loligo

1952 • 1,655 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

1984 • 1,339 citations

Alkaloids: Chemical and Biological Perspectives

1992 • 1,310 citations

Neurotoxins that Act on Voltage-Sensitive Sodium Channels in Excitable Membranes

1980 • 1,236 citations

Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant Axons

1964 • 1,065 citations

Voltage clamp analysis of acetylcholine produced end‐plate current fluctuations at frog neuromuscular junction

1973 • 992 citations

Chemicals as tools in the study of excitable membranes.

1974 • 918 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena.

1966 • 809 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

A quantitative description of end‐plate currents

1972 • 625 citations

Acetylcholine Receptor: An Allosteric Protein

1984 • 620 citations

Acetylcholine Receptor: Complex of Homologous Subunits

1980 • 594 citations

The extracellular patch clamp: A method for resolving currents through individual open channels in biological membranes

1978 • 511 citations

The Selective Inhibition of Delayed Potassium Currents in Nerve by Tetraethylammonium Ion

1967 • 490 citations

Chemistry and Pharmacology of Polypeptide Toxins in Snake Venoms

1972 • 479 citations

The Nicotinic Cholinergic Receptor: Correlation of Molecular Structure with Functional Properties

1982 • 456 citations

Single Na+ channel currents observed in cultured rat muscle cells

1980 • 452 citations

Cloning and sequence analysis of calf cDNA and human genomic DNA encoding α-subunit precursor of muscle acetylcholine receptor

1983 • 433 citations

Alkaloids: Chemical and biological perspectives

1986 • 401 citations

Structural and Functional Properties of the Acetylcholine Receptor Protein in its Purified and Membrane-Bound States

1978 • 399 citations

Quantitation of junctional and extrajunctional acetylcholine receptors by electron microscope autoradiography after (125)I-α-bungarotoxin binding at mouse neuromuscular junctions

1976 • 398 citations

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

1978 • 384 citations

The Cell surface and neuronal function

1980 • 379 citations

Receptors for neurotransmitters and peptide hormones.

1980 • 373 citations

Ionic pores, gates, and gating currents

1974 • 358 citations

ACTIVE PHASE OF FROG'S END-PLATE POTENTIAL

1959 • 348 citations

The Molecular Basis of Neuronal Excitability

1984 • 346 citations

Advances in Cytopharmacology

1973 • 345 citations

Multiple conductance states of single acetylcholine receptor channels in embryonic muscle cells

1981 • 327 citations

Localization of Acetylcholine Receptor by ¹²⁵ I-Labeled α-Bungarotoxin Binding at Mouse Motor Endplates

1974 • 306 citations

Dynamics of aminopyridine block of potassium channels in squid axon membrane.

1976 • 297 citations

Structure and function of an acetylcholine receptor

1982 • 281 citations

Quaternary structure of the acetylcholine receptor

1985 • 281 citations

Studies on the axon membrane. I. A new method

1949 • 272 citations

Purification of the tetrodotoxin-binding component associated with the voltage-sensitive sodium channel from Electrophorus electricus electroplax membranes.

1978 • 270 citations

The actions of tubocurarine at the frog neuromuscular junction.

1979 • 265 citations

Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from Torpedo marmorata

1983 • 250 citations

Tetraethylammonium ions and the potassium permeability of excitable cells

1983 • 248 citations

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions

1979 • 243 citations

Ionic Currents Underlying Activity in the Giant Axon of the Squid

1949 • 243 citations

Biochemical properties of acetylcholine receptor subunits from Torpedo californica

1979 • 239 citations

Interactions of aminopyridines with potassium channels of squid axon membranes

1976 • 234 citations

Voltage jump analysis of procaine action at frog end‐plate

1977 • 230 citations

Membrane potential-dependent binding of scorpion toxin to the action potential Na+ ionophore. Studies with a toxin derivative prepared by lactoperoxidase-catalyzed iodination

1977 • 221 citations

Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in Xenopus oocytes

1982 • 217 citations

Distribution of acetylcholine receptors at frog neuromuscular junctions with a discussion of some physiological implications.

1978 • 217 citations

The mode of action of 4-aminopyridine and guanidine on transmitter release from motor nerve terminals

1977 • 215 citations

Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata

1973 • 212 citations

The effect of internal and external 4‐aminopyridine on the potassium currents in intracellularly perfused squid giant axons

1977 • 212 citations

The charge carried by single‐channel currents of rat cultured muscle cells in the presence of local anaesthetics.

1983 • 211 citations

Stabilization and rectification of muscle fiber membrane by tetrodotoxin

1960 • 204 citations

Slow changes in potassium permeability in skeletal muscle

1970 • 200 citations

Some Factors Affecting the Time Course of the Recovery of Contracture Ability Following a Potassium Contracture in Frog Striated Muscle

1965 • 200 citations

The Relation between Classical and Cooperative Models for Drug Action

1973 • 194 citations

Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venom.

1975 • 194 citations

Effects of tetraethylammonium on potassium currents in a molluscan neurons.

1981 • 193 citations

Single sodium channels from rat brain incorporated into planar lipid bilayer membranes

1983 • 186 citations

Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica

1977 • 183 citations

Histrionicotoxins: Roentgen-Ray Analysis of the Novel Allenic and Acetylenic Spiroalkaloids Isolated from a Colombian Frog, Dendrobates histrionicus

1971 • 179 citations

Generation of end-plate potentials

1976 • 176 citations

Classification of skin alkaloids from neotropical poison-dart frogs (dendrobatidae)

1978 • 173 citations

Proceedings: Selective inhibition of potassium current in the giant axon of the cockroach.

1974 • 172 citations

Dependence of acetylcholine desensitization on the membrane potential of frog muscle fibre and on the ionic changes in the medium

1970 • 172 citations

Tetrodotoxin, Saxitoxin, and Related Substances: Their Applications in Neurobiology

1972 • 172 citations

Effects of 4-aminopyridine on neuromuscular transmission

1978 • 172 citations

The characteristics of ‘end‐plate noise’ produced by different depolarizing drugs

1973 • 171 citations

A quantitative analysis of local anaesthetic alteration of miniature end‐plate currents and end‐plate current fluctuations.

1977 • 169 citations

An analysis of the dose‐response relationship at voltage‐clamped frog neuromuscular junctions.

1978 • 162 citations

Dynamics of Cholinergic Function

1986 • 161 citations

Leçons sur les effets des substances toxiques et medicamenteuses / par M. Claude Bernard.

1857 • 161 citations

Binding of scorpion toxin to receptor sites associated with sodium channels in frog muscle. Correlation of voltage-dependent binding with activation.

1979 • 158 citations

Functional reconstitution of the purified brain sodium channel in planar lipid bilayers.

1985 • 158 citations

Structure of batrachotoxin, a steroidal alkaloid from the Colombian arrow poison frog, phyllobates aurotaenia, and partial synthesis of batrachotoxin and its analogs and homologs

1969 • 157 citations

Single channel currents from excised patches of muscle membrane.

1980 • 157 citations

Mechanism of action of tetrodotoxin and saxitoxin on excitable membranes.

1972 • 156 citations

Voltage-dependence of drug-induced conductance in frog neuromuscular junction.

1975 • 156 citations

Synaptic transmission in squid giant synapse after potassium conductance blockage with external 3- and 4-aminopyridine

1976 • 155 citations

Molecular Mechanisms of Anesthesia

1984 • 154 citations

Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica

1979 • 153 citations

Dart-Poison Frogs

1983 • 152 citations

A re-examination of curare action at the motor endplate

1978 • 150 citations

Determination of dose‐response curves by quantitative ionophoresis at the frog neuromuscular junction.

1978 • 147 citations

Batrachotoxin as a tool to study voltage-sensitive sodium channels of excitable membranes

1985 • 145 citations

Alteration by Xylocaine (Lidocaine) and Its Derivatives of the Time Course of the End Plate Potential

1968 • 143 citations

Molecular Mechanisms of Anesthesia

1981 • 140 citations

Gephyrotoxins, Histrionicotoxins and Pumiliotoxins from the Neotropical Frog Dendrobates histrionicus

1977 • 139 citations

Cooperative activation of action potential Na+ ionophore by neurotoxins.

1975 • 137 citations

The effect of the tetraethylammonium ion on the delayed currents of frog skeletal muscle

1970 • 137 citations

Modification of single Na+ channels by batrachotoxin.

1982 • 137 citations

Factors affecting the time course of decay of end‐plate currents: a possible cooperative action of acetylcholine on receptors at the frog neuromuscular junction.

1975 • 135 citations

Natural Products and Drug Development

1985 • 133 citations

Acetylcholine Receptor and Ion Conductance Modulator Sites at the Murine Neuromuscular Junction: Evidence from Specific Toxin Reactions

1973 • 133 citations

Anatoxin-a: a novel, potent agonist at the nicotinic receptor.

1980 • 133 citations

The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex.

1985 • 130 citations

Further analysis of the mechanisms of action of batrachotoxin on the membrane of myelinated nerve

1979 • 126 citations

Neuropharmacology and pesticide action

1987 • 122 citations

Conductance of channels opened by acetylcholine-like drugs in muscle end-plate

1975 • 121 citations

Identification of a local anesthetic binding site in nicotinic post-synaptic membranes isolated from Torpedo marmorata electric tissue.

1979 • 120 citations

The arrangement of the subunits of the acetylcholine receptor of Torpedo californica.

1983 • 115 citations

Physiological and Pharmacological Manipulations with Light Flashes

1982 • 115 citations

Local anesthetics and histrionicotoxin are allosteric inhibitors of the acetylcholine receptor. Studies of clonal muscle cells.

1982 • 114 citations

Leçons sur les effets des substances toxiques et médicamenteuses

1857 • 113 citations

Identification of a large molecular weight peptide associated with a tetrodotoxin binding protein from the electroplax of Electrophoruselectricus

1980 • 113 citations

Effects of Batrachotoxin on Membrane Potential and Conductance of Squid Giant Axons

1971 • 104 citations

Levels of Batrachotoxin and Lack of Sensitivity to Its Action in Poison-Dart Frogs ( Phyllobates )

1980 • 103 citations

Acetylcholine receptor site density affects the rising phase of miniature endplate currents.

1980 • 101 citations

A Structural Model for the Kinetic Behavior of Hemoglobin

1979 • 97 citations

Potential-dependent interaction of toxin from venom of the scorpion Buthus eupeus with sodium channels in myelinated fibre. Voltage clamp experiments

1980 • 97 citations

A Kinetic Model for the Action of Xylocaine on Receptors for Acetylcholine

1968 • 96 citations

A study of the irreversible cholinesterase inhibitor, diisopropylfluorophosphate, on time course of end-plate currents in frog sartorius muscle.

1974 • 94 citations

The Cholinergic Receptor Protein in Its Membrane Environment

1975 • 93 citations

The venom of the Colombian arrow poison frogPhyllobates bicolor

1963 • 92 citations

The Density of Acetylcholine Receptors and Their Sensitivity in the Postsynaptic Membrane of Muscle Endplates

1974 • 91 citations

The structure of batrachotoxinin A, a novel steroidal alkaloid from the Columbian arrow poison frog, Phyllobates aurotaenia

1968 • 90 citations

Voltage-dependent effect of curare at the frog neuromuscular junction

1977 • 90 citations

Chemical modification reduces the conductance of sodium channels in nerve

1980 • 89 citations

Phencyclidine interactions with the ionic channel of the acetylcholine receptor and electrogenic membrane

1980 • 89 citations

Die Wirkung von Skorpiongift auf die Ionenstr�me des Ranvierschen Schn�rrings

1968 • 88 citations

Purification and functional reconstitution of the voltage-sensitive sodium channel from rabbit T-tubular membranes.

1985 • 88 citations

3H-batrachotoxinin-A benzoate binding to voltage-sensitive sodium channels: inhibition by the channel blockers tetrodotoxin and saxitoxin

1986 • 88 citations

Molecular mechanisms of the potent and stereospecific nicotinic receptor agonist (+)-anatoxin-a.

1986 • 87 citations

Similar dopamine-releasing effects of phencyclidine and nonamphetamine stimulants in striatal slices.

1982 • 85 citations

Proceedings: The actions of 4-aminopyridine on the delayed potassium current in skeletal muscle fibres.

1975 • 84 citations

4‐AMINOPYRIDINE AND EVOKED TRANSMITTER RELEASE FROM MOTOR NERVE ENDINGS

1978 • 84 citations

Batrachotoxin. The Active Principle of the Colombian Arrow Poison Frog, Phyllobates bicolor

1965 • 84 citations

Regulation of [3H]perhydrohistrionicotoxin binding to Torpedo ocellata electroplax by effectors of the acetylcholine receptor.

1981 • 83 citations

Solubilized tetrodotoxin binding component from the electroplax of Electrophorus electricus. Stability as a function of mixed lipid-detergent micelle composition

1979 • 82 citations

Aminopyridines and sparteine as inhibitors of membrane potassium conductance: effects on Myxicola giant axons and the lobster neuromuscular junction.

1976 • 82 citations

Analysis of atropine action at the frog neutromuscular junction.

1977 • 80 citations

Effect of histrionicotoxin on the ionic conductance modulator of the cholinergic receptor: a quantitative analysis of the end-plate current.

1974 • 80 citations

The Acetylcholine Receptor as Part of a Protein Complex in Receptor-Enriched Membrane Fragments from Torpedo californica Electric Tissue

1978 • 79 citations

The pharmacology of batrachotoxin. II. Effect on electrical properties of the mammalian nerve and skeletal muscle membranes.

1971 • 78 citations

Patch-recorded single-channel currents of the purified and reconstituted Torpedo acetylcholine receptor.

1983 • 76 citations

Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica.

1980 • 74 citations

Progress in Cholinergic Biology: Model Cholinergic Synapses

1983 • 73 citations

Pharmacological studies on tarichatoxin, a potent neurotoxin.

1963 • 73 citations

Effects of histrionicotoxin on the chemosensitive and electrical properties of skeletal muscle

1975 • 72 citations

Actions of the histrionicotoxins at the ion channel of the nicotinic acetylcholine receptor and at the voltage-sensitive ion channels of muscle membranes.

1982 • 71 citations

An analysis by low-angle neutron scattering of the structure of the acetylcholine receptor from Torpedo californica in detergent solution

1979 • 71 citations

Kinetic analysis of end plate currents altered by atropine and scopolamine.

1978 • 70 citations

A dangerously toxic new frog (Phyllobates) used by Emberá Indians of western Colombia, with discussion of blowgun fabrication and dart poisoning. Bulletin of the AMNH ; v. 161, article 2

1978 • 70 citations

A voltage‐clamp study of the effect of two lidocaine derivatives on the time course of end‐plate currents.

1976 • 69 citations

Kinetics of agonist conductance changes during hyperpolarization at frog endplates

1997 • 67 citations

The behavioral effects of phencyclidines may be due to their blockade of potassium channels.

1981 • 67 citations

The pharmacology of batrachotoxin. IV. Interaction with tetrodotoxin on innervated and chronically denervated rat skeletal muscle.

1972 • 66 citations

Studies on the effect of histrionicotoxin on the monocellular electroplax from Electrophorus electricus and on the binding of (3H)acetylcholine to membrane fragments from Torpedo marmorata.

1976 • 65 citations

The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ionic channel complex. II. Patch clamp studies.

1984 • 64 citations

Specific binding of perhydrohistrionicotoxin to Torpedo acetylcholine receptor.

1979 • 62 citations

Analysis of Cooperativity of Drug-Receptor Interaction by Quantitative Iontophoresis at Frog Motor End Plates

1976 • 61 citations

Progress in Cholinergic Biology: Model Cholinergic Synapses

1983 • 61 citations

A quantitative description of end‐plate currents in the presence of two lidocaine derivatives.

1976 • 60 citations

Selective labeling of the .delta. subunit of the acetylcholine receptor by a covalent local anesthetic

1981 • 60 citations

The molecular weight of an acetylcholine receptor isolated from Torpedo californica

1975 • 60 citations

Binding of perhydrohistrionicotoxin to intact and detergent-solubilized membranes enriched in nicotinic acetylcholine receptor

1979 • 58 citations

Amantadine: Neuromuscular Blockade by Suppression of Ionic Conductance of the Acetylcholine Receptor

1978 • 58 citations

Activation and desensitization of Torpedo acetylcholine receptor: evidence for separate binding sites.

1982 • 58 citations

Activation, inactivation, and desensitization of acetylcholine receptor channel complex detected by binding of perhydrohistrionicotoxin

1980 • 58 citations

Mechanism of action of amantadine on neuromuscular transmission.

1978 • 58 citations

Characterization of batrachotoxin-induced depolarization of the squid giant axons.

1973 • 57 citations

Quinacrine (mepacrine) action at frog end‐plate.

1980 • 57 citations

Alkaloids of Neotropical Poison Frogs (Dendrobatidae)

1982 • 55 citations

Electrophysiological observations on the action of the purified scorpion venom, tityustoxin, on nerve and skeletal muscle of the rat.

1976 • 55 citations

Diisopropylfluorophosphate: Suppression of Ionic Conductance of the Cholinergic Receptor

1973 • 54 citations

Preliminary evaluation of skin toxins and vocalizations in taxonomic and evolutionary studies of poison-dart frogs (Dendrobatidae). Bulletin of the AMNH ; v. 157, article 3

1976 • 54 citations

Dissection of the 66 000-dalton subunit of the acetylcholine receptor

1981 • 53 citations

Histrionicotoxin enhances agonist-induced desensitization of acetylcholine receptor.

1977 • 53 citations

Voltage- and time-dependent action of histrionicotoxin on the endplate current of the frog muscle.

1978 • 51 citations

Electrophysiological and biochemical studies on enhancement of desensitization by phenothiazine neuroleptics.

1983 • 51 citations

Time-resolved photolabeling by quinacrine azide of a noncompetitive inhibitor site of the nicotinic acetylcholine receptor in a transient, agonist-induced state.

1985 • 51 citations

An analysis of the action of atropine and scopolamine on the end-plate current of frog sartorius muscle.

1976 • 50 citations

Cardiovascular Effects of Snake Venoms

1979 • 50 citations

The pharmacology of batrachotoxin. I. Effects on the contractile mechanism and on neuromuscular transmission of mammalian skeletal muscle.

1971 • 50 citations

An electrophysiological study of the effects of d-tubocurarine, atropine, and α-bungarotoxin on the cholinergic receptor in innervated and chronically denervated mammalian skeletal muscles

1974 • 50 citations

Differentiation of the open and closed states of the ionic channels of nicotinic acetylcholine receptors by tricyclic antidepressants.

1981 • 49 citations

Mode of action of quinacrine on the acetylcholine receptor ionic channel complex.

1979 • 49 citations

Binding of d-tubocurarine and α-bungarotoxin in normal and denervated mouse muscles

1974 • 49 citations

Binding of antibodies to acetylcholine receptors in Electrophorus and Torpedo electroplax membranes.

1978 • 48 citations

The Link between Drug Binding and Response: Theories and Observations

1979 • 47 citations

The pharmacology of batrachotoxin. 3. Effect on the heart Purkinje fibers.

1971 • 46 citations

End‐plate channel opening and the kinetics of quinacrine (mepacrine) block.

1980 • 45 citations

Neuropharmacology and pesticide action

1988 • 45 citations

Phencyclidine in nanomolar concentrations binds to synaptosomes and blocks certain potassium channels.

1983 • 45 citations

Distribution and density of cholinergic receptors at the motor endplates of a denervated mouse muscle

1975 • 43 citations

Interactions of bupivacaine with ionic channels of the nicotinic receptor. Analysis of single-channel currents.

1984 • 41 citations

The acetylcholine receptor and the ionic conductance modulation system of skeletal muscle

1975 • 39 citations

MECHANISM OF NICOTINIC CHANNEL ACTIVATION AND BLOCKADE*

1980 • 39 citations

Sites of action of phencyclidine. I. Effects on the electrical excitability and chemosensitive properties of the neuromuscular junction of skeletal muscle.

1980 • 39 citations

Interactions of perhydrohistrionicotoxin with postsynaptic membranes

1977 • 39 citations

STUDIES ON THE MECHANISM OF CURARIZATION*

1959 • 38 citations

Batrachotoxin, a Selective Probe for Channels Modulating Sodium Conductances in Electrogenic Membranes

1977 • 38 citations

Temperature dependence of ion permeation at the endplate channel.

1983 • 37 citations

Reconstitution of acetylcholine receptor function using purified receptor protein

1981 • 37 citations

Consequences of denervation on the distribution of the cholinergic (nicotinic) receptor sites fromElectrophorus electricus revealed by high resolution autoradiography

1973 • 37 citations

Voltage- and time-dependent actions of piperocaine on the ion channel of the acetylcholine receptor.

1979 • 37 citations

Neuromuscular Transmission

1976 • 35 citations

Relation Between Structure and Action of Quaternary Ammonium Neuromuscular Blocking Agents

1965 • 34 citations

A voyage to China and the East Indies

1771 • 33 citations

Peripheral and central nicotinic ACh receptors — how similar are they?

1982 • 33 citations

The pharmacology of batrachotoxin. VII. Structure-activity relationships and the effects of pH.

1975 • 32 citations

Desensitization at the Motor Endplate

1973 • 32 citations

The Molecular Basis of Neurotransmission: Structure and Function of the Nicotinic Acetylcholine Receptor

1985 • 30 citations

Structure-activity relationships of amantadine. I. Interaction of the N-alkyl analogues with the ionic channels of the nicotinic acetylcholine receptor and electrically excitable membrane.

1982 • 30 citations

A quantitative study of the action ofCentruroides sculpturatus toxins III and IV on the Na currents of the node of Ranvier

1983 • 29 citations

Differential effects of perhydrohistrionicotoxin on neurally and iontophoretically evoked endplate currents.

1978 • 28 citations

Response of acetylcholine receptors to photoisomerizations of bound agonist molecules

1978 • 28 citations

Interactions of d-tubocurarine with the nicotinic acetylcholine receptor/channel molecule.

1982 • 28 citations

Meproadifen reaction with the ionic channel of the acetylcholine receptor: potentiation of agonist-induced desensitization at the frog neuromuscular junction.

1982 • 28 citations

The pharmacology of batrachotoxin. V. A comparative study of membrane properties and the effect of batrachotoxin on sartorius muscles of the frogs Phyllobates aurotaenia and Rana pipiens.

1973 • 28 citations

The mean lifetime of orthopositronium in vacuum

1977 • 28 citations

Voltage-clamp analysis of the sodium and potassium currents in skeletal muscle fibres treated with 4-aminopyridine

1978 • 27 citations

Biophysical Aspects of Agonist Action at Frog Endplate

1979 • 27 citations

Interactions of bupivacaine with ionic channels of the nicotinic receptor. Electrophysiological and biochemical studies.

1984 • 27 citations

Fluctuation analysis of Na+ channels modified by batrachotoxin in myelinated nerve

1981 • 27 citations

New perspectives on the interactions of tetrodotoxin and saxitoxin with excitable membranes

1983 • 25 citations

Effects of 4‐aminopyridine on Statistical Parameters of Transmitter Release at the Neuromuscular Junction

1979 • 25 citations

Interactions of gephyrotoxin with the acetylcholine receptor-ionic channel complex. I. Blockade of the ionic channel.

1984 • 24 citations

Meproadifen enhances activation and desensitization of the acetylcholine receptor‐ionic channel complex (AChR): single channel studies

1984 • 23 citations

Some aspects of the pharmacology of sodium channels in nerve membrane. Process of inactivation

1979 • 23 citations

Possible Site of Action of Batrachotoxin

1971 • 23 citations

Proceedings: Effects of 4-aminopyridine on the potassium current in internally perfused giant axons of the squid.

1975 • 23 citations

Ganglionic and cardiac actions of batrachotoxin

1970 • 22 citations

The effects of batrachotoxin on cat papillary muscle.

1976 • 22 citations

Voltage- and time-dependent effects of phencyclidines on the endplate current arise from open and closed channel blockade.

1986 • 21 citations

Chiriquitoxin, a new tool for mapping ionic channels.

1981 • 21 citations

Effect of 4-aminopyridine on nerve terminal action potentials.

1981 • 21 citations

Effects of phencyclidine and its analogs on the end-plate current of the neuromuscular junction.

1986 • 20 citations

Stereochemical Preferences for Curarimimetic Neuromuscular Junction Blockade I: Enantiomeric Monoquaternary Amines as Probes

1975 • 20 citations

The frog interosseal muscle fiber as a new model for patch clamp studies of chemosensitive- and voltage-sensitive ion channels: actions of acetylcholine and batrachotoxin.

1984 • 17 citations

Interactions of phencyclidine with ion channels of nerve and muscle: behavioral implications.

1983 • 17 citations

174. Curare alkaloids. Part VI. Alkaloids from Chondrodendron tomentosum R. and P.

1947 • 17 citations

Interactions of gephyrotoxin with the acetylcholine receptor-ionic channel complex. II. Enhancement of desensitization.

1984 • 17 citations

Site of action of phencyclidine. IV. Interaction of phencyclidine and its analogues on ionic channels of the electrically excitable membrane and nicotinic receptor: implications for behavioral effects.

1982 • 16 citations

EFFECT OF ATROPINE ON THE DECAY OF MINIATURE END‐PLATE CURRENTS AT THE FROG NEUROMUSCULAR JUNCTION

1976 • 14 citations

Open time of channels activated by binding of two distinct agonists

1980 • 13 citations

The narcotic antagonist naltrexone has a biphasic effect on the nicotinic acetylcholine receptor

1985 • 12 citations

Local anesthetic molecules transiently block currents through individual open acetylcholine receptor channels [proceedings]

1977 • 12 citations

Elucidation of the mechanism and site of action of quinuclidinyl benzilate (QNB) on the electrical excitability and chemosensitivity of the frog sartorius muscle

1981 • 11 citations

Interaction of bicyclo-octane analogs of amantadine with ionic channels of the nicotinic acetylcholine receptor and electrically excitable membrane.

1984 • 11 citations

Stereochemical Preferences for Curarimimetic Neuromuscular Junction Blockade II: Enantiomeric Bisquaternary Amines as Probes

1975 • 10 citations

Demonstration and affinity labeling of a stereoselective binding site for a benzomorphan opiate on acetylcholine receptor-rich membranes from Torpedo electroplaque.

1985 • 10 citations

Batrachotoxin has no effect on the electrogenic membranes of lobster and crayfish muscles

1972 • 9 citations

The ionic channel of the nicotinic acetylcholine receptor is unable to differentiate between the optical antipodes of perhydrohistrionicotoxin

1983 • 9 citations

The comparative activity of arecoline and arecoline N-metho salt

1964 • 9 citations

Discriminant effects of behaviorally active and inactive analogs of phencyclidine on membrane electrical excitability.

1984 • 8 citations

Stereochemical Preferences for Curarimimetic Neuromuscular Junction Blockade III: Enantiomeric Bisquaternary Amines Related to Benzoquinonium as Probes

1975 • 6 citations

Physiological studies on the ionic channel of nicotinic neuromuscular synapses.

1979 • 5 citations

A study of the novel synthetic analog (+/-)-depentylperhydrohistrionicotoxin on the nicotinic receptor-ion channel complex.

1984 • 4 citations

Effect of histrionicotoxin on ion channels in synaptic and conducting membranes of electroplax ofElectrophorus electricus

1983 • 4 citations

Phencyclidine (PCP), in Nanomolar Concentrations, Binds to Synaptosomes and Blocks Certain Potassium Channels

1984 • 4 citations

Appearance of Extrapyramidal Symptoms: Interaction between Neuroleptics and Other CNS Active Drugs

1982 • 4 citations

Interaction of analogs of histrionicotoxin with the acetylcholine receptor ionic channel complex and membrane excitability.

1984 • 3 citations

Stereochemical Preferences for Curarimimetic Neuromuscular Junction Blockade IV: Monoquaternary Ammonium Probes Possessing Carbon and Nitrogen Asymmetry

1979 • 2 citations

Deleted Work

1955 • 0 citations