Interactions of FGFs with target cells

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes.

1982 • 759 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells

1987 • 653 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules

1989 • 597 citations

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

1990 • 545 citations

FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.

1991 • 541 citations

Molecular cloning of syndecan, an integral membrane proteoglycan.

1989 • 505 citations

Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0----G1 transition.

1987 • 422 citations

Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells invitro: Implications for a role of heparinase-like enzymes in the neovascular response

1987 • 416 citations

Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.

1991 • 415 citations

Suramin inhibition of growth factor receptor binding and mitogenicity in AKR‐2B cells

1987 • 387 citations

Recovery of Mitogenic Activity of a Growth Factor Mutant with a Nuclear Translocation Sequence

1990 • 373 citations

The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells.

1985 • 352 citations

Diverse forms of a receptor for acidic and basic fibroblast growth factors.

1990 • 352 citations

Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor.

1991 • 346 citations

Basic and acidic fibroblast growth factors interact with the same cell surface receptors.

1986 • 340 citations

Nuclear and cytoplasmic localization of different basic fibroblast growth factor species

1990 • 332 citations

Translocation of bFGF to the nucleus is G1 phase cell cycle specific in bovine aortic endothelial cells.

1990 • 324 citations

Interaction of endothelial cell growth factor with heparin: characterization by receptor and antibody recognition.

1985 • 301 citations

Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblasts

1986 • 285 citations

Metabolism of receptor-bound and matrix-bound basic fibroblast growth factor by bovine capillary endothelial cells.

1988 • 276 citations

Ligand-affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor.

1990 • 274 citations

Basic Fibroblast Growth Factor (FGF) in the Central Nervous System: Identification of Specific Loci of Basic FGF Expression in the Rat Brain

1989 • 233 citations

Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet‐derived growth factor‐like protein which is secreted

1987 • 229 citations

Role of extracellular matrix in the action of basic fibroblast growth factor: Matrix as a source of growth factor for long‐term stimulation of plasminogen activator production and DNA synthesis

1989 • 227 citations

Solubilization and degradation of subendothelial matrix glycoproteins and proteoglycans by metastatic tumor cells.

1982 • 222 citations

Syndecan, a developmentally regulated cell surface proteoglycan that binds extracellular matrix and growth factors

1990 • 218 citations

Multiple Forms of bFGF: Differential Nuclear and Cell Surface Localization

1991 • 210 citations

Complementary DNA cloning and sequencing of rat ovarian basic fibroblast growth factor and tissue distribution study of its mRNA

1988 • 210 citations

Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration.

1989 • 210 citations

Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line.

1990 • 208 citations

Cell surface fibroblast growth factor and epidermal growth factor receptors are permanently lost during skeletal muscle terminal differentiation in culture.

1988 • 197 citations

Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor).

1987 • 194 citations

Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries.

1988 • 193 citations

Basic fibroblast growth factor is an extracellular matrix component required for supporting the proliferation of vascular endothelial cells and the differentiation of PC12 cells.

1989 • 190 citations

Specific binding of basic fibroblast growth factor to basement membrane‐like structures and to purified heparan sulfate proteoglycan of the EHS tumor

1988 • 172 citations

Heparin modulation of the neurotropic effects of acidic and basic fibroblast growth factors and nerve growth factor on PC12 cells

1987 • 163 citations

The NH₂‐terminal extension of high molecular weight bFGF is a nuclear targeting signal

1991 • 161 citations

Phospholipase C release of basic fibroblast growth factor from human bone marrow cultures as a biologically active complex with a phosphatidylinositol-anchored heparan sulfate proteoglycan.

1991 • 145 citations

Transformation of NIH 3T3 cells with basic fibroblast growth factor or the hst/K-fgf oncogene causes downregulation of the fibroblast growth factor receptor: reversal of morphological transformation and restoration of receptor number by suramin.

1989 • 143 citations

Basic fibroblast growth factor is released from endothelial extracellular matrix in a biologically active form

1989 • 143 citations

MCF7 mammary cancer cells respond to bFGF and internalize it following its release from extracellular matrix: A permissive role of cathepsin D

1991 • 142 citations

Acidic fibroblast growth factor mRNA is expressed by cardiac myocytes in culture and the protein is localized to the extracellular matrix.

1989 • 141 citations

Specific fixation of bovine brain and retinal acidic and basic fibroblast growth factors to mouse embryonic eye basement membranes

1987 • 133 citations

The structure of human acidic fibroblast growth factor and its interaction with heparin

1991 • 129 citations

Regulatory effects of cell density on the binding of transforming growth factor beta, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor.

1988 • 120 citations

Diverse receptors for fibroblast growth factors

1992 • 119 citations

Expression of syndecan, a putative low affinity fibroblast growth factor receptor, in the early mouse embryo

1991 • 115 citations

Characterization of the Neuronal Receptor for Basic Fibroblast Growth Factor and Comparison to Receptors on Mesenchymal Cells

1989 • 113 citations

Glycosylation of the basic fibroblast growth factor receptor. The contribution of carbohydrate to receptor function.

1988 • 112 citations

Evidence and characterization of the receptor to eye-derived growth factor I, the retinal form of basic fibroblast growth factor, on bovine epithelial lens cells.

1986 • 105 citations

The mRNAs encoding acidic FGF, basic FGF and FGF receptor are coordinately downregulated during myogenic differentiation

1991 • 104 citations

Fibroblast growth factor receptor levels decrease during chick embryogenesis.

1990 • 99 citations

Basic fibroblast growth factor accumulates in the nuclei of various bFGF-producing cell types

1990 • 98 citations

Analysis of competence: receptors for fibroblast growth factor in early Xenopus embryos

1989 • 97 citations

Three forms of rat basic fibroblast growth factor are made from a single mRNA and localize to the nucleus

1991 • 94 citations

Reduction of basic fibroblasts growth factor receptor is coupled with terminal differentiation of chondrocytes.

1991 • 93 citations

Internalization of basic fibroblast growth factor (bFGF) in cultured endothelial cells: Role of the low affinity heparin‐like bFGF receptors

1993 • 90 citations

Isolation of a Receptor for Acidic and Basic Fibroblast Growth Factor from Embryonic Chick

1989 • 88 citations

Identification of heparan sulfate proteoglycan as a high affinity receptor for acidic fibroblast growth factor (aFGF) in a parathyroid cell line.

1991 • 86 citations

Protamine sulfate inhibits mitogenic activities of the extracellular matrix and fibroblast growth factor, but potentiates that of epidermal growth factor

1987 • 86 citations

Internalization and processing of basic fibroblast growth factor by neurons and astrocytes

1991 • 83 citations

Cell type and tissue distribution of the fibroblast growth factor receptor

1989 • 77 citations

Fibroblast growth factor phosphorylation and receptors in rod outer segments.

1989 • 76 citations

Expression of two different forms of fibroblast growth factor receptor 1 in different mouse tissues and cell lines.

1991 • 75 citations

Identification of the fibroblast growth factor receptor in human vascular endothelial cells

1988 • 72 citations

Basic fibroblast growth factor requires a long-lasting activation of protein kinase C to induce cell proliferation in transformed fetal bovine aortic endothelial cells.

1991 • 70 citations

Nuclear localization of endogenous basic fibroblast growth factor in cultured endothelial cells

1991 • 64 citations

Purification of basic FGF receptors from rat brain

1988 • 63 citations

Extracellular matrix heparan sulfate proteoglycans modulate the mitogenic capacity of acidic fibroblast growth factor

1989 • 60 citations

Ontogeny of basic fibroblast growth factor binding sites in mouse ocular tissues

1990 • 58 citations

Flg-2, a new member of the family of fibroblast growth factor receptors.

1991 • 54 citations

Binding, internalization, and degradation of basic fibroblast growth factor in human microvascular endothelial cells

1989 • 45 citations

Cell density regulates the number of cell surface receptors for fibroblast growth factor

1989 • 43 citations

Identification and isolation from bovine epithelial lens cells of two basic fibroblast growth factor receptors that possess bFGF-enhanced phosphorylation activities

1989 • 38 citations

Internalization and degradation of heparin binding growth factor-I by endothelial cells

1988 • 38 citations

Presence of basic fibroblast growth factor receptors in bovine brain membranes.

1988 • 37 citations

Distribution of basic fibroblast growth factor binding sites in various tissue membrane preparations from adult guinea pig

1989 • 36 citations

Subcellular Distribution of Basic Fibroblast Growth Factor in Human Hepatoma Cells

1991 • 35 citations

Internalization of basic fibroblast growth factor by Chinese hamster lung fibroblast cells: Involvement of several pathways

1991 • 31 citations

Effect of heparin on the binding affinity of acidic FGF for the cloned human FGF receptors, flg and bek

1990 • 31 citations

Biological and binding studies of acidic fibroblast growth factor in the presence of substituted dextran

1989 • 27 citations

Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.

1991 • 27 citations

Evidence of high and low affinity binding sites for basic fibroblast growth factor in mouse placenta

1990 • 26 citations

Modulation of mitogenic activity and cellular binding of basic fibroblast growth factor by basic proteins

1989 • 25 citations

Internalization and Limited Processing of Basic Fibroblast Growth Factor on Chinese Hamster Lung Fibroblasts

1989 • 24 citations

Proteoheparan Sulfates Contribute to the Binding of Basic FGF to its High Affinity Receptors on Bovine Adrenocortical Cells

1991 • 24 citations

Phorbol ester reduces number of heparin‐binding growth‐factor receptors in human adult endothelial cells

1988 • 22 citations

16-kilodalton heparin binding (fibroblast) growth factor type one appears in a stable 40-kilodalton complex after receptor-dependent internalization.

1991 • 21 citations

Purification from human hepatoma cells of a 130-kDa membrane glycoprotein with properties of the heparin-binding growth factor receptor

1988 • 17 citations

Purification of basic fibroblast growth factor receptors from bovine brain

1989 • 16 citations

High Affinity Receptors to Acidic and Basic Fibroblast Growth Factor (FGF) are Detected Mainly in Adult Brain Membrane Preparations but not in Liver, Kidney, Intestine, Lung or Stomach

1991 • 14 citations

Enhanced MYCN oncogene expression in human neuroblastoma cells is associated with altered FGF receptor expression and cellular growth response to basic FGF

1991 • 11 citations

Binding and effect of atrial natriuretic factor on cyclic GMP formation and alpha-MSH secretion of intermediate pituitary cells

1988 • 8 citations

Étude de la distribution tissulaire et cellulaire des récepteurs aux "Fibroblast growth factors" acide et basique

1991 • 1 citations