Modulation of cytosolic-[Ca2+] oscillations in hepatocytes results from cross-talk among second messengers. The synergism between the α1-adrenergic response, glucagon and cyclic AMP, and their antagonism by insulin and diacylglycerol manifest themselves in the control of the cytosolic-[Ca2+] oscillations

Calcium Channels, Stores, and Oscillations

1990 • 1,208 citations

Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release

1991 • 843 citations

Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes

1986 • 790 citations

Forskolin: a unique diterpene activator of cyclic AMP-generating systems.

1981 • 716 citations

Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin.

1984 • 436 citations

Activation of two signal-transduction systems in hepatocytes by glucagon

1986 • 383 citations

Characterization of Cytosolic Calcium Oscillations Induced by Phenylephrine and Vasopressin in Single Fura-2-loaded Hepatocytes

1989 • 369 citations

Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium.

1988 • 359 citations

Generation of Calcium Oscillations in Fibroblasts by Positive Feedback Between Calcium and IP ₃

1991 • 317 citations

Spatial and temporal aspects of cell signalling

1988 • 278 citations

Gluconeogenesis: Its regulation in mammalian species

1977 • 259 citations

Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid.

1986 • 255 citations

Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.

1986 • 254 citations

Fluorescence measurement and photochemical manipulation of cytosolic free calcium

1988 • 248 citations

Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system

1989 • 247 citations

Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate.

1985 • 218 citations

Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C.

1987 • 203 citations

Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate.

1986 • 198 citations

Ca2+ Oscillations Induced by Hormonal Stimulation of Individual Fura-2-loaded Hepatocytes

1989 • 195 citations

Calcium oscillations in electrically non-excitable cells

1990 • 191 citations

[15] cAMP analog antagonists of cAMP action

1988 • 184 citations

Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.

1987 • 184 citations

The mechanism for synergism between phospholipase C- and adenylylcyclase-linked hormones in liver. Cyclic AMP-dependent kinase augments inositol trisphosphate-mediated Ca2+ mobilization without increasing the cellular levels of inositol polyphosphates.

1991 • 166 citations

Hormone-induced calcium oscillations in liver cells can be explained by a simple one pool model

1991 • 158 citations

Insulin Generates an Enzyme Modulator from Hepatic Plasma Membranes: Regulation of Adenosine 3′, 5′-Monophosphate Phosphodiesterase, Pyruvate Dehydrogenase, and Adenylate Cyclase*

1987 • 142 citations

Phorbol-ester-induced alterations of free calcium ion transients in single rat hepatocytes

1987 • 108 citations

CGS 9343B, a novel, potent, and selective inhibitor of calmodulin activity.

1987 • 105 citations

Insulin-Signaling Mechanisms: Lessons From the Old Testament of Glycogen Metabolism and the New Testament of Molecular Biology

1988 • 96 citations

Epidermal growth factor mimics insulin effects in rat hepatocytes

1986 • 96 citations

Effect of cyclic AMP-dependent hormones and Ca2+-mobilizing hormones on the Ca2+ influx and polyphosphoinositide metabolism in isolated rat hepatocytes

1986 • 87 citations

Insulin inhibition of α-adrenergic actions in liver

1981 • 73 citations

Inhibitors of protein kinase C prolong the falling phase of each free-calcium transient in a hormone-stimulated hepatocyte

1990 • 67 citations

Glucagon and vasopressin interactions on Ca2+ movements in isolated hepatocytes

1986 • 66 citations

Potentiation of alpha 1-adrenergic responses in rat liver by a cAMP-dependent mechanism.

1984 • 59 citations

4 β-Phorbol 12-myristate 13-acetate attenuates the glucagon-induced increase in cytoplasmic free Ca2+ concentration in isolated rat hepatocytes

1986 • 56 citations

Protein kinase C activators inhibit the inositol trisphosphate‐mediated muscarinic current responses in rat lacrimal cells.

1987 • 53 citations

Insulin increases the synthesis of phospholipid and diacylglycerol and protein kinase C activity in rat hepatocytes

1990 • 51 citations

Inhibition of inositol trisphosphate-stimulated calcium mobilization by calmodulin antagonists in rat liver epithelial cells.

1988 • 48 citations

Interactions between insulin and alpha 1-adrenergic agents in the regulation of glycogen metabolism in isolated hepatocytes.

1985 • 46 citations

A Putative Mediator of Insulin Action Which Inhibits Adenylate Cyclase and Adenosine 3′,5′-Monophosphate- Dependent Protein Kinase: Partial Purificaton from Rat Liver: Site and Kinetic Mechanism of Action*

1987 • 38 citations

Phospholipid signaling systems in insulin action

1988 • 38 citations

A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate.

1987 • 36 citations

Binding and action of insulin and glucagon in monolayer cultures and fresh suspensions of rat hepatocytes

1982 • 36 citations

Frequency and amplitude enhancement of calcium transients by cyclic AMP in hepatocytes

1991 • 35 citations

Effects of insulin on phenylephrine-induced activation of phosphorylase and phosphatidylinositol turnover in isolated hepatocytes.

1983 • 28 citations

Recent progress in our understanding of the mechanism of action of insulin

1988 • 21 citations

Hormone-induced intracellular calcium oscillations and mitochondrial energy supply in single hepatocytes

1990 • 19 citations

EGF receptor down-regulation attenuates ligand-induced second messenger formation

1990 • 11 citations