Prostaglandins and the Inflammatory Response

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Adenosine 3‘,5‘-Phosphate in Biological Materials

1962 • 2,102 citations

Superoxide Dismutases

1975 • 1,673 citations

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

1971 • 1,535 citations

Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine

1971 • 1,433 citations

Drugs which inhibit prostaglandin biosynthesis.

1974 • 1,325 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

1979 • 992 citations

Prostaglandins: Stimulation of Bone Resorption in Tissue Culture

1970 • 981 citations

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

1977 • 886 citations

Prostaglandins, Aspirin-like Drugs and Analgesia

1972 • 871 citations

Regulation of the immune response by prostaglandins

1980 • 772 citations

Diglyceride lipase: a pathway for arachidonate release from human platelets.

1979 • 696 citations

Advances in prostaglandin and thromboxane research

1980 • 675 citations

Advances in prostaglandin and thromboxane research

1976 • 602 citations

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

1976 • 600 citations

Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds

1981 • 477 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids.

1979 • 465 citations

Slow reacting substances of anaphylaxis: Identification of leukotrienes C-1 and D from human and rat sources

1980 • 433 citations

Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritis.

1975 • 393 citations

Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets

1975 • 393 citations

Prostacyclin is a circulating hormone

1978 • 380 citations

The Biosynthesis and Metabolism of Prostaglandins

1979 • 366 citations

Prostaglandin biosynthesis can be triggered by lipid peroxides

1979 • 357 citations

LEUKOTRIENES

1983 • 347 citations

Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig

1975 • 339 citations

Cutaneous reactions to intradermal prostaglandins

1971 • 337 citations

The Isolation of Prostaglandin F from Sheep Prostate Glands.

1960 • 318 citations

Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiency.

1975 • 312 citations

Role of prostaglandin endoperoxide PGG2 in inflammatory processes

1977 • 307 citations

Über die Spezifische Blutdrucksenkende Substanz des Menschlichen Prostata- und Samenblasensekretes

1935 • 305 citations

Structure of leukotriene C identification of the amino acid part

1979 • 304 citations

Prostaglandins, peptides and amines,

1969 • 295 citations

Effect of Prostaglandin E1 on Adjuvant Arthritis

1971 • 264 citations

Limitation of Excessive Myelopoiesis by the Intrinsic Modulation of Macrophage-Derived Prostaglandin E

1978 • 263 citations

Corticosteroids inhibit prostaglandin production by rheumatoid synovia

1975 • 261 citations

Prostaglandins in Cellular Biology

1972 • 260 citations

Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.

1979 • 258 citations

Introduction of a nomenclature: Leukotrienes

1979 • 257 citations

Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages.

1982 • 247 citations

The Isolation of Prostaglandin E from Sheep Prostate Glands.

1960 • 246 citations

Parallel assay of prostaglandin-like activity in rat inflammatory exudate by means of cascade superfusion

1969 • 240 citations

Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids

1975 • 239 citations

Fluorescent Labeling of Fatty Acids with 9-Anthryldiazomethane (ADAM) for High Performance Liquid Chromatography

1980 • 210 citations

Regulation of arachidonate metabolism via lipoxygenase and cyclo-oxygenase by 12-HPETE, the product of human platelet lipoxygenase

1979 • 208 citations

Recovery of Prostaglandins in Human Cutaneous Inflammation

1971 • 206 citations

Measuring leukotrienes of slow reacting substance of anaphylaxis: development of a specific radioimmunoassay.

1983 • 205 citations

Prostaglandin and thromboxane production by human and guinea-pig macrophages and leucocytes

1979 • 197 citations

Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint

1975 • 196 citations

Indomethacin in submicromolar concentrations inhibits cyclic AMP-dependent protein kinase

1978 • 193 citations

Slow Reacting Substances (SRSs): The structure identification of SRSs from rat basophil leukaemia (RBL-1) cells

1980 • 192 citations

Nutritional and Pharmacological Factors in Eicosanoid Biology

2009 • 191 citations

Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells

1975 • 184 citations

Precursor role of arachidonic acid in release of slow reacting substance from rat basophilic leukemia cells.

1977 • 183 citations

Stimulation of bone resorption by various prostaglandins in organ culture

1975 • 181 citations

Effect of mechanical stimulation on rabbits' eyes: release of active substance in anterior chamber perfusates

1965 • 177 citations

Pharmacologic Agents Released in Ultraviolet Inflammation Studied by Continuous Skin Perfusion

1970 • 167 citations

Effects of prostaglandin E2 on rat skin: inhibition of sterol ester biosynthesis and clearing of scaly lesions in essential fatty acid deficiency

1972 • 159 citations

Nomenclature for leukotrienes

1980 • 157 citations

Participation of superoxide anions at the prostaglandin phase of carrageenan foot-oedema

1976 • 153 citations

Action of Prostaglandin E1 on Tissues which respond to Bradykinin

1963 • 139 citations

Monocytes regulate osteoclast-activating factor production by releasing prostaglandins.

1979 • 138 citations

9-Diazomethylanthracene as a new fluorescence and ultraviolet label for the spectrometric detection of picomole quantities of fatty acids by high-pressure liquid chromatography

1980 • 137 citations

The metabolism of dihomo‐γ‐linolenic acid in man

1979 • 132 citations

Prostaglandin e₁ treatment of NZB/NZW F₁ hybrid MICE

1977 • 132 citations

Levels of Prostaglandins F₂α and E₂and Thromboxane B₂In Joint Fluid in Rheumatoid Arthritis

1977 • 131 citations

Suppression of immune complex vasculitis in rats by prostaglandin.

1979 • 129 citations

In vitro synthesis of prostaglandins and related lipids by populations of human peripheral blood mononuclear cells

1980 • 128 citations

THE SYNOVIAL PROSTAGLANDIN SYSTEM IN CHRONIC INFLAMMATORY ARTHRITIS: DIFFERENTIAL EFFECTS OF STEROIDAL AND NONSTEROIDAL ANTI‐INFLAMMATORY DRUGS

1981 • 124 citations

Immunologic Release of Histamine and Slow Reacting Substance of Anaphylaxis from Human Lung

1973 • 124 citations

Prostaglandins are necessary for osteoclast-activating factor production by activated peripheral blood leukocytes.

1979 • 118 citations

Treatment of Raynaud's phenomenon by intravenous infusion of prostacyclin (PGI2)

1982 • 117 citations

Suppression by prostaglandin E1 of vascular permeability induced by vasoactive inflammatory mediators.

1980 • 114 citations

Specific suppression of human T lymphocyte function by leukotriene B4.

1983 • 113 citations

Separation, Identification, and Estimation of Prostaglandins

1969 • 113 citations

Differential effects of dietary fatty acids on the accumulation of arachidonic acid and its metabolic conversion through the cyclooxygenase and lipoxygenase in platelets and vascular tissue

1981 • 111 citations

Determination of cyclooxygenase products and prostaglandin metabolites using high-pressure liquid chromatography and radioimmunoassay

1979 • 108 citations

LEUKOTRIENES C₄ AND D₄ INDUCE PROSTAGLANDIN AND THROMBOXANE RELEASE FROM RAT PERITONEAL MACROPHAGES

1981 • 102 citations

Mediators of Anaphylaxis and Inflammation

1982 • 99 citations

Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins

1973 • 96 citations

Uptake and metabolism of monohydroxy-eicosatetraenoic acids by macrophages.

1982 • 93 citations

Effect of Prostaglandin E2 on Adjuvant Arthritis

1969 • 91 citations

Inhibition of sheep vesicular gland oxygenase by unsaturated fatty acids from skin of essential fatty acid deficient rats

1974 • 90 citations

Is prostacyclin the major pro-inflammatory prostanoid in joint fluid?

1980 • 89 citations

Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold

1973 • 85 citations

Prostaglandin E1 inhibits T-cell proliferation and renal disease in mice

1981 • 80 citations

Fluorescent/ultraviolet absorbing ester derivative formation and analysis of eicosanoids by high-pressure liquid chromatography

1982 • 80 citations

Prostaglandin activity in human cutaneous inflammation: Detection by radioimmunoassay

1973 • 76 citations

PROSTAGLANDIN E1: EFFECT ON HUMAN CUTANEOUS VASCULATURE AND SKIN HISTAMINE

1971 • 75 citations

Prostaglandins and anti-inflammatory drugs in the dog knee joint

1972 • 74 citations

Induction of prostaglandin E release from macrophages by colchicine.

1980 • 73 citations

CONGENITAL DEFICIENCY OF THROMBOXANE AND PROSTACYCLIN

1980 • 72 citations

A SIMPLE CHEMICAL PROCEDURE FOR DISTINGUISHING E FROM F PROSTAGLANDINS, WITH APPLICATION TO TISSUE EXTRACTS

1968 • 71 citations

Human monocytes synthesize eicosanoids from T lymphocyte-derived arachidonic acid

1982 • 70 citations

Prostaglandin synthesis by rheumatoid synovium and its stimulation by colchicine

1975 • 68 citations

Action of corticosteroids in regulation of prostaglandin biosynthesis in cultured fibroblasts.

1978 • 65 citations

Arachidonic acid metabolism in glutathione-deficient macrophages.

1982 • 64 citations

Prostaglandins, thromboxanes, and polymorphonuclear leukocytes

1977 • 64 citations

Reduced exudation and increased tissue proliferation during chronic inflammation in rats deprived of endogenous prostaglandin precursors

1977 • 64 citations

[61] Separation of arachidonic acid metabolites by high-pressure liquid chromatography

1982 • 63 citations

Prostaglandins and Cutaneous Inflammation

1975 • 62 citations

The Mode of Action of Anti-inflammatory Drugs which Prevent the Peroxidation of Arachidonic Acid

1980 • 59 citations

Prostaglandin e₁ (pge₁) suppression of adjuvant arthritis histopathology

1973 • 57 citations

Synthesis of prostaglandins by subpopulations of human peripheral blood monocytes

1979 • 56 citations

Comparative effects of aspirin and diflunisal on prostaglandin synthetase from human platelets and sheep seminal vesicles.

1977 • 56 citations

Prostaglandin synthetase activity from human rheumatoid synovial microsomes. Effect of 'aspirin-like' drug therapy.

1976 • 56 citations

EFFECTS OF ANTI-INFLAMMATORY DRUGS ON LYMPHOCYTES

1967 • 53 citations

Sensitive high-performance liquid chromatographic method for prostaglandins using a fluorescence reagent, 4-bromomethyl-7-acetoxycoumarin

1982 • 51 citations

Prostaglandins, immune responses, and murine lupus

1982 • 51 citations

Indomethacin potentiates PGE1 stimulated cyclic AMP accumulation in human synoviocytes

1974 • 50 citations

Changes in lymphocyte sensitivity to prostaglandin E, histamine, hydrocortisone, and X irradiation with age: Studies in a healthy elderly population

1982 • 49 citations

Pathogenesis of Crystal-Induced Synovitis

1977 • 48 citations

Prostaglandin E1 treatment of NZB/W mice

1978 • 48 citations

PROSTAGLANDINS, KININ AND INFLAMMATION IN THE RAT

1974 • 48 citations

Prostaglandin production in arthritis.

1978 • 47 citations

The nature of the prostaglandin-producing mononuclear cell in human peripheral blood.

1981 • 47 citations

Hydrocortisone inhibition of the bradykinin activation of human synovial fibroblasts

1977 • 46 citations

Essential fatty acid deficiency: A condition to discriminate prostaglandin and non-prostaglandin mediated components of inflammation

1976 • 46 citations

TIME‐DEPENDENT STIMULATORY AND INHIBITORY EFFECTS OF PROSTAGLANDIN E_x ON EXUDATIVE AND TISSUE COMPONENTS OF GRANULOMATOUS INFLAMMATION IN RATS

1979 • 46 citations

EFFECTS OF ASPIRIN ON PROSTAGLANDIN AND FRUCTOSE LEVELS IN HUMAN SEMEN

1973 • 45 citations

Rat platelets aggregate in the absence of endogenous precursors of prostaglandin endoperoxides

1976 • 42 citations

Radical scavenging as the mechanism for stimulation of prostaglandin cyclooxygenase and depression of inflammation by lipoic acid and sodium iodide

1978 • 41 citations

Prostaglandin synthetase activity from human rheumatoid synovial tissue and its inhibition by non-steroidal anti-inflammatory drugs

1975 • 41 citations

Prostaglandin E2 elevation of cyclic-AMP in granuloma macrophages at various stages of inflammation: Relevance to anti-inflammatory and immunomodulatory functions

1981 • 38 citations

The effect of anti-inflammatory agents on human synovial fibroblast prostaglandin synthetase

1976 • 38 citations

Immunohistochemical localization of prostaglandin e in rheumatoid synovial tissues

1977 • 37 citations

The role of prostaglandins in the local control of circulation.

1975 • 33 citations

In vitro and in vivo arachidonic acid conversions into biologically active derivatives are enhanced by uric acid

1981 • 32 citations

Xanthine oxidase-induced foot-edema in rats: Involvement of oxygen radicals

1978 • 32 citations

Murine lupus—an overview

1982 • 30 citations

PGE2 and PGF2α biosynthesis in stimulated and nonstimulated peritoneal preparations containing macrophages

1977 • 29 citations

Increased collagen metabolism in granulomata induced in rats deficient in endogenous prostaglandin precursors

1977 • 28 citations

Interaction of the unique competitive inhibitor imidazole with human carbonic anhydrase B

1977 • 27 citations

Influence of prostaglandins (PG) E2 and F2α on the inflammatory process

1973 • 27 citations

Cyclic AMP response to prostaglandin E1 in mononuclear cells from peripheral blood and synovial fluid of patients with rheumatoid arthritis

1977 • 26 citations

Effects of prostaglandin E1 on microvascular haemodynamics in progressive systemic sclerosis.

1982 • 26 citations

Treatment of murine immune complex glomerulonephritis with prostaglandin E2: Dose-response of immune complex deposition, antibody synthesis, and glomerular damage

1983 • 26 citations

High performance liquid chromatography (HPLC) of arachidonic acid metabolites

1982 • 26 citations

Leukotriene C stimulates prostaglandin release from rat peritoneal macrophages

1981 • 25 citations

9,11-Iminoepoxyprosta-5,13-dienoic acid is a selective thromboxane A2 synthetase inhibitor

1979 • 24 citations

Prostaglandins in vascular disease: a seminal approach.

1981 • 24 citations

Linolenic Acid Deficiency In Man

2009 • 23 citations

Effect of Ibuprofen, a fatty acid cyclooxygenase inhibitor, on murine lupus

1982 • 22 citations

Animal Models for Systemic Lupus Erythematosus

1975 • 21 citations

The effects of PGE1 on lymphocytes in NZB/W mice

1980 • 19 citations

Mechanism of stimulation of prostaglandin synthesis by a factor from rheumatoid synovial tissue.

1981 • 19 citations

Functional and biochemical heterogeneity among subpopulations of rat and mouse peritoneal macrophages.

1982 • 16 citations

Prostaglandins in synovial inflammatory disease.

1974 • 16 citations

Prostaglandin E2 secretion by subsets of human peripheral blood monocytes

1982 • 16 citations

In Vivo and In Vitro Actions of a New Selective Inhibitor of Leukotriene C and D Synthesis

1983 • 16 citations

The role of prostaglandins in the development of macrophages from bone marrow cells.

1980 • 14 citations

Mechanism of intervention of uric acid metabolism in PG biosynthesis

1981 • 12 citations

Genetic, environmental, and cellular factors in the pathogenesis of systemic lupus erythematosus

1982 • 12 citations

Recent Developments in the Pharmacology of Inflammatory Mediators

1977 • 12 citations

Contraction of Glycerol Extracted Fibres of Smooth Muscle by Acetylcholine and Imidazole in the Presence of a Ca‐binding Microsomal Fraction from Rabbit Colon

1976 • 10 citations

Natural factors modulating the intervention of activated oxygen in the biosynthesis of prostanoids.

1981 • 10 citations

Immunoelectron microscopic demonstration of prostaglandin e in rheumatoid synovium

1982 • 10 citations

A phlogistic function of PGE1 in calcium pyrophosphate dihydrate crystal-induced inflammation.

1975 • 8 citations

Prostaglandin E1 treatment of NZB/W F1 hybrids—Induction of in vitro and in vivo cell-mediated immune responses to DNA

1980 • 7 citations

Indomethacin inhibitsin vitro immunoglobulin production by human B-lymphocytes

1981 • 7 citations

Indomethacin modulates plasma membrane-associated properties of macrophages

1982 • 6 citations

Effects of indomethacin treatment on human peripheral blood monocytes

1981 • 5 citations

The effects of prostaglandins PGE1, PGE2, PGF1a, and PGF2a on canine synovial perfusion

1975 • 5 citations

Prostaglandin research: Clinical implications

1982 • 4 citations

Treatment of severe Raynaud's phenomenon with prostaglandin E1

1981 • 3 citations

I.免疫複合体病変をめぐる問題

1979 • 2 citations

Free Radical Mechanisms

1983 • 2 citations