Tumoricidal Effector Mechanisms of Murine BCG-Activated Macrophages: Role of TNF in Conjugation-Dependent and Conjugation-Independent Pathways

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Cachectin and tumour necrosis factor as two sides of the same biological coin

1986 • 1,659 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

Identification of a membrane-associated interleukin 1 in macrophages.

1985 • 487 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells.

1985 • 430 citations

The active form of tumor necrosis factor is a trimer.

1987 • 430 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Cellular receptor for 125I-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity.

1985 • 287 citations

Macrophages Activated in Vitro with Lymphocyte Mediators Kill Neoplastic but not Normal Cells

1975 • 244 citations

Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes.

1987 • 192 citations

Discrimination Between Neoplastic and Non-Neoplastic Cells In Vitro by Activated Macrophages12

1974 • 191 citations

Binding of human tumor necrosis factor to high affinity receptors on HeLa and lymphoblastoid cells sensitive to growth inhibition.

1985 • 183 citations

Evidence for the existence of two forms of membrane tumor necrosis factor: an integral protein and a molecule attached to its receptor.

1989 • 119 citations

Quantification and characterization of high‐affinity membrane receptors for tumor necrosis factor on human leukemic cell lines

1986 • 110 citations

Susceptibility of Normal and Transformed Cell Lines to Cytostatic and Cytocidal Effects Exerted by Macrophages 2

1976 • 97 citations

Species specificity of human and murine tumor necrosis factor. A comparative study of tumor necrosis factor receptors.

1986 • 95 citations

Interaction of BCG-activated macrophages with neoplastic and nonneoplastic cell lines in vitro: Cinemicrographic analysis

1975 • 95 citations

Tumor necrosis factor as effector molecule in monocyte mediated cytotoxicity.

1986 • 89 citations

Recognition and destruction of target cells by tumoricidal macrophages.

1978 • 86 citations

Alternative Cleavage of the Cachectin/Tumor Necrosis Factor Propeptide Results in a Larger, Inactive Form of Secreted Protein

1989 • 75 citations

Plasma membrane-associated tumor necrosis factor. A non-integral membrane protein possibly bound to its own receptor.

1988 • 69 citations

Molecular weight of recombinant human tumor necrosis factor-alpha.

1987 • 60 citations

Tumor necrosis factor and IL-1 associated with plasma membranes of activated human monocytes lyse monokine-sensitive but not monokine-resistant tumor cells whereas viable activated monocytes lyse both.

1988 • 60 citations

Binding of human TNF-α to high-affinity cell surface receptors: Effect of IFN

1986 • 59 citations

Necrosin: purification and properties of a cytotoxin derived from a murine macrophage-like cell line.

1984 • 42 citations

Characterization and affinity crosslinking of receptors for tumor necrosis factor on human cells

1986 • 36 citations

Tumour necrosis factor-like activity on paraformaldehyde-fixed monocyte monolayers.

1987 • 31 citations

Synthesis and maturation of recombinant human tumor necrosis factor in eukaryotic systems

1986 • 27 citations

Improvement of cytotoxicity of tumor necorosis factor (TNF) by increase in basicity of its N-terminal region

1987 • 26 citations

Demonstration of membrane receptors for human natural and recombinant ¹²⁵I‐labeled tumor necrosis factor on HeLa cell clones and their role in tumor cell sensitivity

1986 • 25 citations

A rapid extremely sensitive, quantitative microassay for cytotoxic cytokines.

1985 • 22 citations

Tumoricidal effector mechanisms of murine Bacillus Calmette-Guérin-activated macrophages: mediation of cytolysis, mitochondrial respiration inhibition, and release of intracellular iron by distinct mechanisms.

1987 • 18 citations

Cytostatic product(s) released by activated macrophages, unrelated to interleukin 1, tumor necrosis factor α, and interferon-αβ

1988 • 16 citations

Effect of antisera against recombinant tumor necrosis factor and the monocyte-derived cytotoxin(s) on monocyte-mediated killing of various tumor cells

1987 • 6 citations

L-Arginine independent macrophage tumor cytotoxicity

1989 • 5 citations