Molecular mechanisms in tumor-cell killing by activated macrophages

Textbook of Rheumatology

1985 • 1,671 citations

Active Oxygen Species and the Functions of Phagocytic Leukocytes

1980 • 1,124 citations

Natural Cell-Mediated Immunity

1978 • 1,063 citations

Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering.

1977 • 488 citations

Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide.

1979 • 423 citations

Purification and physico-chemical characterization of rabbit tumor necrosis factor.

1980 • 386 citations

Activated macrophages kill tumour cells by releasing arginase

1978 • 307 citations

Heterocytolysis by Macrophages Activated by Bacillus Calmette-Gurin: Lysosome Exocytosis into Tumor Cells

1974 • 278 citations

Macrophage fibrinolytic activity: Identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor

1982 • 225 citations

Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis

1981 • 220 citations

Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted neutral proteases.

1980 • 206 citations

Effector mechanisms of cytolytically activated macrophages. I. Secretion of neutral proteases and effect of protease inhibitors.

1980 • 194 citations

Role of oxygen-dependent mechanisms in antibody-induced lysis of tumor cells by activated macrophages

1980 • 192 citations

Suppression of in vitro cytotoxic response by macrophages due to induced arginase.

1977 • 189 citations

Mononuclear phagocytes : functional aspects

1980 • 172 citations

Synthesis and Release of Thymidine by Macrophages

1977 • 171 citations

Effects of activated complement components on enzyme secretion by macrophages.

1976 • 162 citations

Identification of the cell multiplication inhibitory factors in interferon preparations as interferons

1976 • 129 citations

Morphological evidence for the translocation of lysosomal organelles from cytotoxic macrophages into the cytoplasm of tumor target cells.

1976 • 115 citations

Receptors for Maleylated Proteins Regulate Secretion of Neutral Proteases by Murine Macrophages

1982 • 112 citations

Effects of Lysozyme on Normal and Transformed Mammalian Cells

1973 • 108 citations

Activated macrophages release a factor which lyses malignant cells but not normal cells.

1975 • 105 citations

Preliminary characterization of the tumor cell cytotoxin in tumor necrosis serum.

1981 • 94 citations

Heterogeneity of mononuclear phagocytes

1981 • 92 citations

Role of oxygen in antibody-dependent cytotoxicity mediated by monocytes and neutrophils.

1980 • 91 citations

Generation and characterization of a lipopolysaccharide-induced and serum-derived cytotoxic factor for tumor cells

1980 • 88 citations

Mechanisms of Cell-Mediated Cytotoxicity

1982 • 88 citations

Endocytosis of red blood cells or haemoglobin by activated macrophages inhibits their tumoricidal effect

1977 • 84 citations

Augmentation of spontaneous macrophage-mediated cytolysis by eosinophil peroxidase

1982 • 75 citations

Inhibition of nonspecific tumoricidal activity by activated macrophages with antiserum against a soluble cytotoxic factor

1981 • 62 citations

Hydrogen peroxide and cytolytic factor can interact synergistically in effecting cytolysis of neoplastic targets.

1981 • 57 citations

Differential arginine dependence and the selective cytotoxic effects of activated macrophages for malignant cells in vitro

1978 • 55 citations

Role of tumor cell membrane-bound serine proteases in tumor-induced target cytolysis.

1982 • 46 citations

Evidence for both oxygen and non-oxygen dependent mechanisms of antibody sensitized target cell lysis by human monocytes

1980 • 44 citations

Demonstration of membrane-bound proteolytic activity on the surface of mononuclear leukocytes

1981 • 44 citations

Mechanism of Nonspecific Macrophage-Mediated Cytotoxicity: Evidence for Lack of Dependence upon Oxygen

1978 • 39 citations

The binding of BCG-activated macrophages to tumor targets stimulates secretion of cytolytic factor.

1981 • 36 citations

Macrophage-mediated antibody-dependent cellular cytotoxicity

1985 • 35 citations

The relationship between competence for secretion of H2O2 and completion of tumor cytotoxicity by BCG-elicited murine macrophages.

1982 • 35 citations

Monocyte-mediated antibody-dependent cell-mediated cytotoxicity: the role of the metabolic burst

1981 • 31 citations

Mechanism of action of mouse macrophages as antitumor effector cells: Role of arginase

1980 • 31 citations

Tumour-necrosis factor from the rabbit. IV. Purification and chemical characterization

1980 • 31 citations

Inducible Macrophage Cytotoxins. II. Tumor Lysis Mechanism Involving Target Cell-Binding Proteases<xref ref-type="fn" rid="FN2">2</xref>

1982 • 30 citations

Stimulation of peritoneal cell arginase by bacterial lipopolysaccharides.

1980 • 29 citations

Functional heterogeneity among peritoneal macrophages

1980 • 18 citations

Inability of the C3a anaphylatoxin to promote cellular lysis

1980 • 18 citations

Inability of tumour cells to elicit the respiratory burst in cytotoxic, activated macrophages.

1982 • 17 citations

Inducible Macrophage Cytotoxins. I. Biokinetics of Activation and Release In Vitro<xref ref-type="fn" rid="FN2">2</xref>

1982 • 15 citations

In vitro killing of tumor cells by soluble products of activated guinea pig peritoneal macrophages

1980 • 15 citations

Analysis of the Lytic Step in the Herpes Simplex Virus Antibody-Dependent Cellular Cytotoxicity System

1980 • 6 citations