Inhibition of stromal matrix metalloproteases: Effects on breast-tumor promotion by fibroblasts

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

1996 • 515 citations

Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.

1995 • 511 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis

1995 • 429 citations

Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases.

1992 • 429 citations

Fibroblast-mediated acceleration of human epithelial tumor growth in vivo.

1990 • 417 citations

Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor

1996 • 287 citations

Epidermal growth factor or transforming growth factor alpha is required for kidney tubulogenesis in matrigel cultures in serum-free medium.

1990 • 243 citations

Matrix metalloproteinase inhibition: A review of anti-tumour activity

1995 • 226 citations

Enhanced Tumor Growth of Both Primary and Established Human and Murine Tumor Cells in Athymic Mice After Coinjection With Matrigel

1991 • 216 citations

Gelatinase A activity directly modulates melanoma cell adhesion and spreading.

1995 • 199 citations

Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo.

1994 • 189 citations

Metastasis from human breast cancer cell lines

1996 • 159 citations

Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts

1993 • 146 citations

Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion.

1996 • 134 citations

The role of fibroblasts in tumor behavior

1995 • 125 citations

The matrix metalloproteinases and their inhibitors in pancreatic cancer

1997 • 108 citations

Stromelysin-3 expression promotes tumor take in nude mice.

1996 • 92 citations

Identification of Structural Determinants Controlling Human and Mouse Stromelysin-3 Proteolytic Activities

1995 • 72 citations

Coordinate enhancement of gelatinase a mRNA and activity levels in human fibroblasts in response to breast‐adenocarcinoma cells

1994 • 58 citations

Stimulation of angiogenesis as an explanation of matrigel‐enhanced tumorigenicity

1994 • 48 citations

Fibroblast‐dependent tumorigenicity of melanoma xenografts in athymic mice

1992 • 21 citations