USE OF CTLA4-Ig IN COMBINATION WITH CONVENTIONAL IMMUNOSUPPRESSIVE AGENTS TO PROLONG ALLOGRAFT SURVIVAL

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 303 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 294 citations

Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.

1995 • 271 citations

Studies on heterologous anti-lymphocyte serum in mice. II. Effect on the immune response.

1966 • 214 citations

CD43 is a murine T cell costimulatory receptor that functions independently of CD28.

1995 • 137 citations

CTLA4-Ig PLUS BONE MARROW INDUCES LONG-TERM ALLOGRAFT SURVIVAL AND DONOR-SPECIFIC UNRESPONSIVENESS IN THE MURINE MODEL

1996 • 122 citations

The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells.

1996 • 104 citations

The Effect of Combination Cyclosporine and CTLA4-Ig Therapy on Cardiac Allograft Survival

1994 • 47 citations

BLOCKADE OF MULTIPLE COSTIMULATORY RECEPTORS INDUCES HYPORESPONSIVENESS

1996 • 42 citations

Long-term survival of rat to mouse cardiac xenografts with prolonged blockade of CD28-B7 interaction combined with peritransplant T-cell depletion

1996 • 20 citations