Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis.

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

BOTH ALLOANTIGEN-DEPENDENT AND -INDEPENDENT FACTORS INFLUENCE CHRONIC ALLOGRAFT REJECTION

1995 • 378 citations

BOTH ALLOANTIGEN-DEPENDENT AND -INDEPENDENT FACTORS INFLUENCE CHRONIC ALLOGRAFT REJECTION

1995 • 340 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 303 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 294 citations

The spectrum of coronary artery pathologic findings in human cardiac allografts.

1989 • 283 citations

cDNA cloning by PCR of rat transforming growth factor β-1

1990 • 274 citations

CHRONIC VASCULAR REJECTION OF THE HEART AND THE KIDNEY—HAVE RATIONAL TREATMENT OPTIONS EMERGED?

1992 • 152 citations

EXPERIMENTAL GRAFT ARTERIOSCLEROSIS

1992 • 143 citations

UPREGULATION OF CYTOKINES ASSOCIATED WITH MACROPHAGE ACTIVATION IN THE LEWIS-TO-F344 RAT TRANSPLANTATION MODEL OF CHRONIC CARDIAC REJECTION1,2

1995 • 141 citations

Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance

1994 • 139 citations

Upregulation and Modulation of Inducible Nitric Oxide Synthase in Rat Cardiac Allografts With Chronic Rejection and Transplant Arteriosclerosis

1995 • 135 citations

Early and persistent induction of monocyte chemoattractant protein 1 in rat cardiac allografts.

1993 • 128 citations

Prevention Of Chronic Rejection And Graft Arteriosclerosis By Tolerance Induction

1995 • 73 citations

T cell costimulatory pathways

1995 • 73 citations

EXPERIMENTAL GRAFT ARTERIOSCLEROSIS II. IMMUNOCYTOCHEMICAL ANALYSIS OF LESION DEVELOPMENT

1993 • 65 citations

Up-regulation of endothelin-1 mRNA and peptide expression in rat cardiac allografts with rejection and arteriosclerosis.

1995 • 60 citations

Lymphocytic subsets and histopathologic changes associated with the development of heart transplant arteriosclerosis.

1992 • 57 citations

Cytomegalovirus infection enhances mRNA expression of platelet-derived growth factor-BB and transforming growth factor-beta 1 in rat aortic allografts. Possible mechanism for cytomegalovirus-enhanced graft arteriosclerosis.

1994 • 56 citations

Cardiac graft vascular disease. Nonselective involvement of large and small vessels.

1993 • 49 citations

Identification and upregulation of galactose/N-acetylgalactosamine macrophage lectin in rat cardiac allografts with arteriosclerosis.

1994 • 48 citations

Expression of cytokine genes in human cardiac allografts: correlation of IL-6 and transforming growth factor-beta (TGF-β) with histological rejection

1993 • 47 citations

INTRATHYMIC TOLERANCE IN THE LEWIS-TO-F344 CHRONIC CARDIAC ALLOGRAFT REJECTION MODEL

1995 • 21 citations

Prevention Of Chronic Rejection And Graft Arteriosclerosis By Tolerance Induction

1995 • 5 citations

Heterotopic Heart Transplantation in Rodents

2024 • 1 citations