Novel Diversity in IL-4-Mediated Responses in Resting Human Naive B Cells Versus Germinal Center/Memory B Cells

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

1993 • 691 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

B-Cell Stimulatory Factor-1/Interleukin 4

1987 • 602 citations

Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23

1990 • 585 citations

Generation of Memory B Cells and Plasma Cells in Vitro

1995 • 585 citations

Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.

1993 • 457 citations

Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes.

1987 • 449 citations

Germinal centres in T-cell-dependent antibody responses

1992 • 442 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

Antigen-induced B-cell death and elimination during germinal-centre immune responses

1995 • 377 citations

Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression.

1992 • 366 citations

Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by Rapid Up-Regulation of B7-1 and B7-2

1995 • 358 citations

Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein.

1994 • 344 citations

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4

1997 • 293 citations

Impaired mucosal immune responses in interleukin 4-targeted mice.

1995 • 227 citations

The maturation of the immune response

1993 • 219 citations

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2.

1996 • 211 citations

Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction.

1994 • 182 citations

The germinal center: a crucible for lymphocyte selection

1996 • 166 citations

Memory B Cells Are Biased Towards Terminal Differentiation: A Strategy That May Prevent Repertoire Freezing

1997 • 161 citations

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

1996 • 158 citations

IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells

1998 • 155 citations

Constitutive Expression of Interleukin (IL)-4 In Vivo Causes Autoimmune-type Disorders in Mice

1997 • 151 citations

CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype.

1996 • 147 citations

Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells

1994 • 127 citations

Germinal Center Founder Cells Display Propensity for Apoptosis before Onset of Somatic Mutation

1997 • 126 citations

Memory, but not naive, peripheral blood B lymphocytes differentiate into Ig-secreting cells after CD40 ligation and costimulation with IL-4 and the differentiation factors IL-2, IL-10, and IL-3.

1997 • 118 citations

The distribution of IL-13 receptor α1 expression on B cells, T cells and monocytes and its regulation by IL-13 and IL-4

1998 • 104 citations

Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells.

1994 • 86 citations

Characterization of transforming growth factor-beta 1 induced apoptosis in normal human B cells and lymphoma B cell lines.

1995 • 82 citations

Negative selection of human germinal center B cells by prolonged BCR cross-linking.

1996 • 68 citations

A Pivotal Role of Cyclin D3 and Cyclin-Dependent Kinase Inhibitor p27 in the Regulation of IL-2-, IL-4-, or IL-10-Mediated Human B Cell Proliferation

1998 • 67 citations

Lymphocyte Development and Selection in Germinal Centers

1998 • 62 citations

Regulation of apoptosis by tyrosine-containing domains of IL-4R alpha: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis.

1998 • 59 citations

Subpopulations of B lymphocytes in germinal centers.

1987 • 44 citations

IL-4 Promotes the Migration of Circulating B Cells to the Spleen and Increases Splenic B Cell Survival

2000 • 43 citations

Regulation of interleukin 4 receptors on human T cells

1990 • 42 citations

Antigen receptor‐induced apoptosis of human germinal center B cells is targeted to a centrocytic subset

1997 • 40 citations

Modulation of the p27kip1 cyclin-dependent kinase inhibitor expression during IL-4-mediated human B cell activation.

1997 • 39 citations

Regulation of Apoptosis by Tyrosine-Containing Domains of IL-4Rα: Y497 and Y713, But Not the STAT6-Docking Tyrosines, Signal Protection from Apoptosis

1998 • 38 citations

Co-ligation of surface IgM and CD40 on naive B lymphocytes generates a blast population with an ambiguous extrafollicular/germinal centre cell phenotype

1996 • 34 citations

Identification of a tonsil IgD⁺ B cell subset with phenotypical and functional characteristics of germinal center B cells

1996 • 32 citations

Distinct sequence motifs within the cytoplasmic domain of the human IL-4 receptor differentially regulate apoptosis inhibition and cell growth.

1995 • 30 citations

Recombinant Tumor Necrosis Factor Enhances the Locomotion of Memory and Naive B Lymphocytes From Human Tonsils Through the Selective Engagement of the Type II Receptor

1997 • 29 citations

Expression of IL-4 Receptor on Human T and B Lymphocytes

1993 • 27 citations

Relationships Between B Cell Cytokine Production in Secondary Lymphoid Follicles and Apoptosis of Germinal Center B Lymphocytes

1995 • 25 citations

Recombinant Tumor Necrosis Factor Enhances the Locomotion of Memory and Naive B Lymphocytes From Human Tonsils Through the Selective Engagement of the Type II Receptor

1997 • 20 citations

The Epstein–Barr virus‐binding site on CD21 is involved in CD23 binding and interleukin‐4‐induced IgE and IgG4 production by human B cells

1996 • 18 citations

Interleukin-4 receptor expression by human B cells: Functional analysis with a human interleukin-4 toxin, DAB389IL-4

1995 • 14 citations

Subpopulations of B lymphocytes in germinal centers, II. A germinal center B cell subpopulation expresses sIgD and CD23

1989 • 14 citations

Interleukin‐4 Induces In Vitro Migration in Naive B Cells Through Direct Mechanisms

1994 • 3 citations

Cited By (0)

Loading...