Regulation of Cytotoxic T Lymphocyte-Associated Molecule-4 by Src Kinases

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

LAT

1998 • 1,251 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

Recruitment of Tyrosine Phosphatase HCP by the Killer Cell Inhibitory Receptor

1996 • 625 citations

Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

1996 • 529 citations

Complex Complexes: Signaling at the TCR

1996 • 512 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

1996 • 390 citations

CTLA-4: a negative regulator of autoimmune disease.

1996 • 382 citations

Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.

1996 • 362 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

Tyrosine Phosphorylation Controls Internalization of CTLA-4 by Regulating Its Interaction with Clathrin-Associated Adaptor Complex AP-2

1997 • 334 citations

Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.

1993 • 319 citations

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes

1998 • 295 citations

Human Influence on the Atmospheric Vertical Temperature Structure: Detection and Observations

1996 • 289 citations

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.

1995 • 260 citations

CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis.

1996 • 232 citations

Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.

1997 • 225 citations

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase.

1996 • 214 citations

Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages.

1997 • 197 citations

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

1997 • 182 citations

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

1993 • 178 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.

1994 • 172 citations

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

1995 • 164 citations

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.

1995 • 161 citations

Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) Interferes with Extracellular Signal-regulated Kinase (ERK) and Jun NH2-terminal Kinase (JNK) Activation, but Does Not Affect Phosphorylation of T Cell Receptor ζ and ZAP70

1997 • 153 citations

Dynamics of Oxidation of a Fe ²⁺ -Bearing Aluminosilicate (Basaltic) Melt

1996 • 148 citations

Interaction of the Cytoplasmic Tail of CTLA-4 (CD152) with a Clathrin-Associated Protein Is Negatively Regulated by Tyrosine Phosphorylation

1997 • 126 citations

The Phosphotyrosine Phosphatase SHP-2 Participates in a Multimeric Signaling Complex and Regulates T Cell Receptor (TCR) coupling to the Ras/Mitogen-activated Protein Kinase (MAPK) Pathway in Jurkat T Cells

1998 • 118 citations

p56^ and p59^ regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor binding protein GRB-2 and T cell specific kinase ITK: implications for T cell co-stimulation.

1995 • 80 citations

Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK

1996 • 77 citations

Signal Transduction by the Lymphocyte-Specific Tyrosine Protein Kinase p56lck

1996 • 64 citations

Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein- associated p62 protein

1998 • 59 citations

CD28 signal transduction: tyrosine phosphorylation and receptor association of phosphoinositide‐3 kinase correlate with Ca²⁺‐independent costimulatory activity

1994 • 42 citations

Differential Phosphorylation of the T Lymphocyte Costimulatory Receptor CD28

1996 • 21 citations

Reconstitution of an active surface CD2 by DNA transfer in CD2-CD3+ Jurkat cells facilitates CD3-T cell receptor-mediated IL-2 production.

1991 • 19 citations