Deletion of lactose repressor carboxyl-terminal domain affects tetramer formation.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Computed circular dichroism spectra for the evaluation of protein conformation

1969 • 3,654 citations

X-Ray Structure of the GCN4 Leucine Zipper, a Two-Stranded, Parallel Coiled Coil

1991 • 1,433 citations

pEMBL: a new family of single stranded plasmids

1983 • 1,231 citations

lac repressor-operator interaction

1970 • 791 citations

The three operators of the lac operon cooperate in repression.

1990 • 487 citations

Sequence of the lacI gene

1978 • 463 citations

lac repressor forms loops with linear DNA carrying two suitably spaced lac operators.

1987 • 353 citations

DNA binding of the lac repressor

1968 • 279 citations

How lac Repressor Binds to DNA

1972 • 228 citations

Lac Repressor

1973 • 215 citations

Lac repressor and Lac operator

1976 • 187 citations

On the assay, isolation and characterization of the lac repressor

1968 • 181 citations

Interaction of effecting ligands with lac repressor and repressor-operator complex

1975 • 181 citations

Genetic studies of the lac repressor

1990 • 173 citations

Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy

1990 • 139 citations

Genetic studies of the lac repressor

1979 • 134 citations

DNA supercoiling changes the spacing requirement of two lac operators for DNA loop formation with lac repressor.

1988 • 132 citations

DNA binding characteristics of lactose repressor and the trypsin-resistant core repressor.

1980 • 118 citations

Equilibrium binding of inducer to lac repressor.operator DNA complex.

1980 • 94 citations

Conformational prediction and circular dichroism studies on the lac repressor

1975 • 94 citations

X-ray scattering indicates that the leucine zipper is a coiled coil.

1991 • 90 citations

Missense mutation in the lacI gene of Escherichia coli

1988 • 87 citations

DNA looping in cellular repression of transcription of the galactose operon.

1990 • 86 citations

Genetic studies of the lac repressor

1979 • 85 citations

Macromolecular binding equilibria in the lac repressor system: studies using high-pressure fluorescence spectroscopy

1990 • 81 citations

Lac repressor - lac operator interaction. Circular dichroism study

1981 • 80 citations

Recognition helices of lac and lambda repressor are oriented in opposite directions and recognize similar DNA sequences.

1988 • 76 citations

DNA-binding properties of a lac repressor mutant incapable of forming tetramers.

1991 • 75 citations

[41] Techniques to assay repressors

1971 • 73 citations

Thermodynamic analysis of the lactose repressor-operator DNA interaction

1986 • 69 citations

Evidence for leucine zipper motif in lactose repressor protein

1991 • 67 citations

Mutations affecting the quaternary structure of the lac repressor.

1976 • 66 citations

Solution structure of the DNA-binding domain of the yeast transcriptional activator protein GCN4

1990 • 65 citations

Limited proteolytic digestion of lac repressor by trypsin. Chemical nature of the resulting trypsin-resistant core.

1976 • 61 citations

Supercoiling facilitates lac operator-repressor-pseudooperator interactions.

1987 • 60 citations

Stability of a Lac repressor mediated "looped complex"

1991 • 59 citations

Dissociation of the lactose repressor-operator DNA complex: effects of size and sequence context of operator-containing DNA

1986 • 58 citations

Characterization of mutations in oligomerization domain of Lac repressor protein.

1991 • 58 citations

Tryptic core protein of lactose repressor binds operator DNA.

1979 • 47 citations

Interaction of lac repressor with inducer. Kinetic and equilibrium measurements

1977 • 43 citations

A comparison of lac repressor binding to operator and to nonoperator DNA

1975 • 42 citations

Characterization and modification of a monomeric mutant of the lactose repressor protein

1986 • 40 citations

Ultraviolet light induces different spectra of lacI sequence changes in vegetative and conjugating cells of Escherichia coli

1988 • 35 citations

Cloning and characterization of several dominant-negative and tight-binding mutants of lac repressor

1986 • 29 citations

Exposure of antigenic sites during immunization. Monoclonal antibodies to monomer of lactose repressor protein.

1985 • 25 citations

Binding of lac repressor induces different conformational changes on operator and non‐operator DNAs

1982 • 18 citations

Composite predictions of secondary structures of lac repressor

1979 • 17 citations

Simultaneous deletion of the intervening sequences from the human interferon-γ gene by oligodeoxynucleotide-directed mutagenesis

1987 • 3 citations