DNA looping in cellular repression of transcription of the galactose operon.

Experiments in molecular genetics

1972 • 28,260 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

The locus of sequence-directed and protein-induced DNA bending

1984 • 1,453 citations

Gene regulation by proteins acting nearby and at a distance

1986 • 886 citations

ISOLATION OF THE LAC REPRESSOR

1966 • 657 citations

DYNAMIC, STRUCTURAL, AND REGULATORY ASPECTS OF λ SITE-SPECIFIC RECOMBINATION

1989 • 607 citations

Sur la biosynthese de la β-galactosidase (lactase) chez Escherichia coli. La specificite de l'induction

1951 • 600 citations

Characterization of a “silencer” in yeast: A DNA sequence with properties opposite to those of a transcriptional enhancer

1985 • 531 citations

The three operators of the lac operon cooperate in repression.

1990 • 487 citations

The Chemical Effects ofNucleic Acid Alkylation and Their Relation to Mutagenesis and Carcinogen esis

1975 • 446 citations

An operator at -280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression.

1984 • 375 citations

A repressor (MATα2 product) and its operator control expression of a set of cell type specific genes in yeast

1985 • 368 citations

lac repressor forms loops with linear DNA carrying two suitably spaced lac operators.

1987 • 353 citations

Multiple DNA-pRotein Interactions Governing High-Precision DNA Transactions

1986 • 302 citations

A control element within a structural gene: The gal operon of Escherichia coli

1983 • 206 citations

Upstream Operators Enhance Repression of the lac Promoter

1986 • 197 citations

MULTIPARTITE GENETIC CONTROL ELEMENTS: COMMUNICATION BY DNA LOOP

1989 • 188 citations

RAP-1 factor is necessary for DNA loop formation in vitro at the silent mating type locus HML

1989 • 184 citations

DNA loops induced by cooperative binding of λ repressor

1986 • 165 citations

Use of polylysine for adsorption of nuclei acids and enzymes to electron microscope specimen films.

1977 • 153 citations

Galactose-sensitive mutants of Salmonella I. Metabolism of galactose

1961 • 140 citations

Modulation of the two promoters of the galactose operon of Escherichia coli

1979 • 132 citations

Demonstration of two operator elements in gal: in vitro repressor binding studies.

1984 • 130 citations

Lac repressor is a transient gene-activating protein

1987 • 123 citations

The Location of the Repressor Binding Sites in the lac Operon

1974 • 112 citations

DNA-protein recognition: demonstration of three genetically separated operator elements that are required for repression of the Escherichia coli deoCABD promoters by the DeoR repressor.

1986 • 107 citations

DNA bending by negative regulatory proteins: Gal and Lac repressors.

1989 • 106 citations

DNA Looping

1988 • 78 citations

Recognition helices of lac and lambda repressor are oriented in opposite directions and recognize similar DNA sequences.

1988 • 76 citations

Single and double loop formation when deoR repressor binds to its natural operator sites

1989 • 70 citations

Interaction of spatially separated protein-DNA complexes for control of gene expression: operator conversions.

1988 • 67 citations

Specific destruction of the second lac operator decreases repression of the lac operon in Escherichia coli fivefold

1987 • 65 citations

Construction, Isolation and Implications of Repressor‐galactosidase ·ß‐galactosidase Hybrid Molecules

1977 • 61 citations

Purification and properties of Gal repressor:pL-galR fusion in pKC31 plasmid vector.

1987 • 60 citations

Dissociation of the lactose repressor-operator DNA complex: effects of size and sequence context of operator-containing DNA

1986 • 58 citations

Repressor Recognition of Operator and Effectors

1980 • 53 citations

RNA polymerase and gal repressor bind simultaneously and with DNA bending to the control region of the Escherichia coli galactose operon.

1989 • 44 citations

The prodigious warp of NGC4013

1987 • 36 citations

Mechanism of activation of transcription by the complex formed between cyclic AMP and its receptor in Escherichia coli

1986 • 26 citations

lac: The Genetic System

1980 • 25 citations

Specialized Nucleoprotein Structures in high‐fidelity DNA transactions

1984 • 12 citations