The three operators of the lac operon cooperate in repression.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Genetic regulatory mechanisms in the synthesis of proteins

1961 • 6,378 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

1985 • 2,505 citations

DNAase footprinting a simple method for the detection of protein-DNA binding specificity

1978 • 2,092 citations

Transcription of glnA in E. coli is stimulated by activator bound to sites far from the promoter

1986 • 444 citations

λ Repressor and cro—components of an efficient molecular switch

1981 • 385 citations

An operator at -280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression.

1984 • 375 citations

Interactions between DNA-bound repressors govern regulation by the λ phage repressor

1979 • 329 citations

The lac operator is DNA.

1967 • 303 citations

Diffusion-driven mechanisms of protein translocation on nucleic acids. 2. The Escherichia coli lac repressor-operator interaction: equilibrium measurements

1981 • 299 citations

Mécanismes régulateurs dans la biosynthèse des enzymes du métabolisme du galactose chez Escherichia coli K12

1963 • 258 citations

A perfectly symmetric lac operator binds the lac repressor very tightly.

1983 • 256 citations

DNA supercoiling promotes formation of a bent repression loop in lac DNA

1987 • 252 citations

DNA sequence for a low-level promoter of the lac repressor gene and an ‘up’ promoter mutation

1978 • 251 citations

A control element within a structural gene: The gal operon of Escherichia coli

1983 • 206 citations

Upstream Operators Enhance Repression of the lac Promoter

1986 • 197 citations

The interaction of the recognition helix of lac repressor with lac operator.

1987 • 151 citations

Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair.

1984 • 129 citations

Lac repressor is a transient gene-activating protein

1987 • 123 citations

DNA binding characteristics of lactose repressor and the trypsin-resistant core repressor.

1980 • 118 citations

The Location of the Repressor Binding Sites in the lac Operon

1974 • 112 citations

DNA bending by negative regulatory proteins: Gal and Lac repressors.

1989 • 106 citations

Long-range cooperativity between gene regulatory sequences in a prokaryote

1987 • 106 citations

Protein—ligand interactions

1975 • 98 citations

Missense mutation in the lacI gene of Escherichia coli

1988 • 87 citations

Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter.

1986 • 87 citations

DNA looping in cellular repression of transcription of the galactose operon.

1990 • 86 citations

Lac repressor - lac operator interaction. Circular dichroism study

1981 • 80 citations

Recognition helices of lac and lambda repressor are oriented in opposite directions and recognize similar DNA sequences.

1988 • 76 citations

Comparison of ultraviolet irradiation-induced mutagenesis of the lacI gene in Escherichia coli and in human 293 cells

1989 • 69 citations

The functional repressor parts of a tetrameric lac repressor-beta-galactosidase chimaera are organized as dimers.

1976 • 67 citations

Interaction of spatially separated protein-DNA complexes for control of gene expression: operator conversions.

1988 • 67 citations

Specific destruction of the second lac operator decreases repression of the lac operon in Escherichia coli fivefold

1987 • 65 citations

Construction, Isolation and Implications of Repressor‐galactosidase ·ß‐galactosidase Hybrid Molecules

1977 • 61 citations

Supercoiling facilitates lac operator-repressor-pseudooperator interactions.

1987 • 60 citations

Probing co-operative DNA-binding in vivo

1988 • 58 citations

REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF THE ENZYMES OF GALACTOSE METABOLISM IN ESCHERICHIA COLI K 12. I. THE INDUCED BIOSYNTHESIS OF GALACTOKINASE AND THE SIMULTANEOUS INDUCTION OF THE ENZYMATIC SEQUENCE

1963 • 57 citations

Why should DNA loop?

1987 • 57 citations

Characterization of two mutations in the Escherichia coli galE gene inactivating the second galactose operator and comparative studies of repressor binding.

1983 • 57 citations

Influence of supercoiling and sequence context on operator DNA binding with lac repressor.

1987 • 54 citations

“Second” and “third operator” of the lac operon: An investigation of their role in the regulatory mechanism

1979 • 50 citations

Dual mechanism of repression at a distance in the lac operon.

1988 • 46 citations

The upstream operator of the Escherichia coli galactose operon is sufficient for repression of transcription initiated at the cyclic AMP-stimulated promoter.

1986 • 30 citations

Characteristics of tight binding repressors of the lac operon

1981 • 28 citations

Deletions fusing the i and lac regions of the chromosome in E. coli: Isolation and mapping

1974 • 18 citations

A versatile phage lambda expression vector system for cloning in Escherichia coli

1989 • 17 citations

Themacpromoters: functional hybrid promoters activated by themalTproduct and repressed by thelacIproduct

1985 • 16 citations