Signaling events during swelling and regulatory volume decrease.

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Excitotoxic cell death

1992 • 2,307 citations

Functional Significance of Cell Volume Regulatory Mechanisms

1998 • 1,871 citations

Skepinone-L, a Novel Potent and Highly Selective Inhibitor of p38 MAP Kinase, Effectively Impairs Platelet Activation and Thrombus Formation

2013 • 1,823 citations

Glutamate release in severe brain ischaemia is mainly by reversed uptake

2000 • 1,105 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Membrane mechanisms in volume and pH regulation in vertebrate cells

1989 • 880 citations

Sgk1-Dependent Stimulation of Cardiac Na⁺/H⁺Exchanger Nhe1 by Dexamethasone

2013 • 842 citations

Structure and function of phosphoinositide 3-kinases

1998 • 666 citations

Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor

1997 • 652 citations

Cellular and molecular physiology of volume-sensitive anion channels

1996 • 620 citations

Current concepts of brain edema

1995 • 412 citations

Signaling to Rho GTPases

1999 • 411 citations

Properties of volume-regulated anion channels in mammalian cells

1997 • 357 citations

Calcium signaling in cell volume regulation

1992 • 349 citations

Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux

1993 • 331 citations

Imaging cell volume changes and neuronal excitation in the hippocampal slice

1994 • 302 citations

Regulation of cell function by the cellular hydration state

1994 • 270 citations

Rho family GTPases: the cytoskeleton and beyond

1996 • 262 citations

The cytoskeleton and cell volume regulation

2001 • 260 citations

Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats

1991 • 237 citations

Cell volume in the regulation of hepatic function: a mechanism for metabolic control

1991 • 225 citations

hSK4/hIK1, a Calmodulin-binding KCa Channel in Human T Lymphocytes

1999 • 216 citations

Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances.

1993 • 211 citations

Dissociation of Synchronization and Excitability in Furosemide Blockade of Epileptiform Activity

1995 • 202 citations

20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells

1998 • 198 citations

PHYSIOLOGICAL AND PATHOLOGICAL ASPECTS OF ASTROCYTIC SWELLING

1986 • 193 citations

Rapid Mechanotransduction in Situ at the Luminal Cell Surface of Vascular Endothelium and Its Caveolae

1998 • 191 citations

Activation of the osmo-sensitive chloride conductance involves P21rho and is accompanied by a transient reorganization of the F-actin cytoskeleton.

1996 • 171 citations

Mitogen-Activated Protein and Tyrosine Kinases in the Activation of Astrocyte Volume-Activated Chloride Current

1998 • 166 citations

The Tyrosine Kinase p56lck Mediates Activation of Swelling-induced Chloride Channels in Lymphocytes

1998 • 161 citations

A Serine Residue in ClC-3 Links Phosphorylation–Dephosphorylation to Chloride Channel Regulation by Cell Volume

1999 • 159 citations

Identification of the Phosphorylation Sites of Cytosolic Phospholipase A2 in Agonist-stimulated Human Platelets and HeLa Cells

1998 • 157 citations

Heterologous expression of specific K+ channels in T lymphocytes: functional consequences for volume regulation.

1993 • 155 citations

Tyrosine kinase activation is an immediate and essential step in hypotonic cell swelling-induced ERK activation and c-fos gene expression in cardiac myocytes.

1996 • 152 citations

Role of Rho and Rho kinase in the activation of volume‐regulated anion channels in bovine endothelial cells

1999 • 140 citations

Reduced intracellular ionic strength as the initial trigger for activation of endothelial volume-regulated anion channels

1999 • 140 citations

Phospholipase A2 as a mechanosensor

1995 • 139 citations

Chloride channels: a molecular perspective

1996 • 137 citations

Potassium and Taurine Release Are Highly Correlated with Regulatory Volume Decrease in Neonatal Primary Rat Astrocyte Cultures

1994 • 126 citations

Swelling and potassium uptake in cultured astrocytes

1987 • 120 citations

Activation of volume‐regulated chloride currents by reduction of intracellular ionic strength in bovine endothelial cells

1998 • 119 citations

Characterization of the voltage-dependent properties of a volume-sensitive anion conductance.

1995 • 118 citations

Phosphatidylinositol 3-Kinase Contributes to Cell Volume Regulation through Effects on ATP Release

1998 • 114 citations

Intracellular ionic strength regulates the volume sensitivity of a swelling-activated anion channel

1998 • 112 citations

Cell swelling activates separate taurine and chloride channels in Ehrlich mouse ascites tumor cells

1994 • 111 citations

Protein Kinase Signaling Pathway Triggered by Cell Swelling and Involved in the Activation of Glycogen Synthase and Acetyl-CoA Carboxylase in Isolated Rat Hepatocytes

1996 • 110 citations

Pharmacological characterization of swelling-induced<scp>d</scp>-[³H]aspartate release from primary astrocyte cultures

1998 • 106 citations

Inhibition by anion channel blockers of ischemia-evoked release of excitotoxic and other amino acids from rat cerebral cortex

1997 • 105 citations

Red cell volume regulation: the pivotal role of ionic strength in controlling swelling-dependent transport systems

1991 • 103 citations

Mechanisms of glutamate and aspartate release in the ischemic rat cerebral cortex

1996 • 100 citations

Stimulation of p38 Phosphorylation and Activity by Arachidonic Acid in HeLa Cells, HL60 Promyelocytic Leukemic Cells, and Human Neutrophils

1998 • 100 citations

Volume regulation in brain cells: Cellular and molecular mechanisms

1996 • 98 citations

Involvement of p38MAPK in the regulation of proteolysis by liver cell hydration

1999 • 98 citations

Separate taurine and chloride efflux pathways activated during regulatory volume decrease

1999 • 97 citations

Influence of Calcium on Regulatory Volume Decrease: Role of Potassium Channels

2000 • 92 citations

Caveolin‐1 modulates the activity of the volume‐regulated chloride channel

1999 • 89 citations

Hypo‐osmotic cell swelling activates the p38 MAP kinase signalling cascade

1996 • 88 citations

Cellular and subcellular redistribution of glutamate-, glutamine- and taurine-like immunoreactivities during forebrain ischemia: A semiquantitative electron microscopic study in rat hippocampus

1991 • 86 citations

Adaptive decreases in amino acids (taurine in particular), creatine, and electrolytes prevent cerebral edema in chronically hyponatremic mice: Rapid correction (experimental model of central pontine myelinolysis) causes dehydration and shrinkage of brain

1987 • 82 citations

Swelling-Induced Arachidonic Acid Release via the 85-kDa cPLA₂in Human Neuroblastoma Cells

1998 • 79 citations

Altered taurine release following hypotonic stress in astrocytes from mice deficient for GFAP and vimentin

1998 • 79 citations

Single-channel properties of a volume-sensitive anion conductance. Current activation occurs by abrupt switching of closed channels to an open state.

1995 • 78 citations

Functional and molecular characterization of a volume‐sensitive chloride current in rat brain endothelial cells

1999 • 78 citations

Cell Swelling Activates Phospholipase A 2 in Ehrlich Ascites Tumor Cells

1997 • 77 citations

Annexin II Modulates Volume-activated Chloride Currents in Vascular Endothelial Cells

1996 • 76 citations

Forskolin Stimulates Swelling-Induced Chloride Current, Not Cardiac Cystic Fibrosis Transmembrane-Conductance Regulator Current, in Human Cardiac Myocytes

1995 • 74 citations

Disruption of Mitochondrial Respiration Inhibits Volume-Regulated Anion Channels and Provokes Neuronal Cell Swelling

1998 • 72 citations

Inhibition of volume-activated I- and taurine efflux from HeLa cells by P-glycoprotein blockers correlates with calmodulin inhibition.

1994 • 71 citations

Signaling Mechanisms Involved in the Activation of Arachidonic Acid Metabolism in Human Astrocytoma Cells by Tumor Necrosis Factor‐α

1999 • 70 citations

On the Role of Calcium in the Regulatory Volume Decrease (RVD) Response in Ehrlich Mouse Ascites Tumor Cells

1997 • 70 citations

Mammalian retinal glial (Müller) cells express large‐conductance Ca ²⁺ ‐activated K ⁺ channels that are modulated by Mg ²⁺ and pH and activated by protein kinase A

1997 • 70 citations

Roles of neuroactive amino acids in ammonia neurotoxicity.

1998 • 69 citations

Taurine efflux and the regulation of cell volume in incubated slices of rat cerebral cortex

1994 • 67 citations

Volume-sensitive chloride current in pigmented ciliary epithelial cells: role of phospholipases

1997 • 65 citations

Volume-dependent taurine release from cultured astrocytes requires permissive [Ca²⁺]_iand calmodulin

1999 • 63 citations

[³H]taurine and<scp>d</scp>-[³H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases

1999 • 62 citations

Native Kv1.3 Channels are Upregulated by Protein Kinase C

1997 • 61 citations

Activation of the volume-sensitive chloride current in vascular endothelial cells requires a permissive intracellular Ca2+ concentration

1996 • 60 citations

Volume-activated chloride currents in pancreatic duct cells

1995 • 60 citations

Osmotic regulation of the heat shock response in primary rat hepatocytes

1998 • 58 citations

Cell Swelling Activates Stress-Activated Protein Kinases, p38 MAP Kinase and JNK, in Renal Epithelial A6 Cells

1999 • 58 citations

Tyrosine phosphorylation modulates the osmosensitivity of volume‐dependent taurine efflux from glial cells in the rat supraoptic nucleus

2000 • 56 citations

A swelling‐activated chloride current in rat sympathetic neurones

1997 • 54 citations

Cyclic AMP prevents activation of a swelling‐induced chloride‐sensitive conductance in chick heart cells.

1995 • 54 citations

THE PRENATAL GROWTH OF THE MOUSE

1927 • 54 citations

Cell Volume Regulation: Intracellular Transmission

1993 • 52 citations

Volume Expansion Stimulates p72 and p56 in Skate Erythrocytes

1999 • 52 citations

Characterization of volume-sensitive taurine- and Cl(-)-permeable channels

1997 • 50 citations

Modulation of phosphoenolpyruvate carboxykinase mRNA levels by the hepatocellular hydration state

1994 • 50 citations

Phosphorylation of P-glycoprotein by PKA and PKC modulates swelling-activated Cl⁻currents

1999 • 48 citations

Inhibition by polyunsaturated fatty acids of cell volume regulation and osmolyte fluxes in astrocytes

1995 • 46 citations

Ion Channels, Cell Volume, and Apoptotic Cell Death

1998 • 46 citations

The volume-activated chloride current in endothelial cells from bovine pulmonary artery is not modulated by phosphorylation

1996 • 44 citations

Protein kinase C stimulates swelling-induced chloride current in canine atrial cells

1999 • 41 citations

Volume sensitive efflux of taurine in HEK293 cells overexpressing phospholemman

2000 • 41 citations

Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in Intestine 407 cells involves the Ras/Raf-signalling pathway

1998 • 41 citations

Intracellular cyclic AMP inhibits native and recombinant volume‐regulated chloride channels from mammalian heart

2000 • 40 citations

Differences in Ca2+-mediation of hypotonic and Na+-nutrient regulatory volume decrease in suspensions of jejunal enterocytes

1992 • 38 citations

Swelling-activated amino acid efflux in the human neuroblastoma cell line CHP-100

1996 • 36 citations

Modulation of dog atrial swelling-induced chloride current by cAMP: protein kinase A-dependent and -independent pathways.

1997 • 36 citations

Volume regulation in human fibroblasts: role of Ca2+ and 5-lipoxygenase products in the activation of the Cl? efflux

1993 • 36 citations

Swelling-induced chloride currents in neuroblastoma cells are calcium dependent

1995 • 36 citations

Hyposmotically induced amino acid release from the rat cerebral cortex: role of phospholipases and protein kinases

1999 • 35 citations

Influence of protein kinases on the osmosensitive release of taurine from cerebellar granule neurons

2001 • 33 citations

Calcium dependence of hypoosmotically induced potassium release in cultured astrocytes

1994 • 33 citations

Chapter 6: Swelling of C6 glioma cells and astrocytes from glutamate, high K+ concentrations or acidosis

1992 • 32 citations

Regulation of the Taurine Content in Ehrlich Ascites Tumour Cells

1998 • 30 citations

Chloride channels activated by hypotonicity in N2A neuroblastoma cell line

1999 • 30 citations

Phospholemman: A Cardiac Taurine Channel Involved in Regulation of Cell Volume

1998 • 29 citations

Effect of protein kinase C inhibitors on Cl- conductance required for volume regulation after L-alanine cotransport

1992 • 28 citations

Cl⁻and K⁺conductances activated by cell swelling in primary cultures of rabbit distal bright convoluted tubules

1997 • 28 citations

Ca 2+ /Calmodulin Kinase II and Decreases in Intracellular pH are Required to Activate K + Channels After Substantial Swelling in Villus Epithelial Cells

1999 • 27 citations

Osmolarity modulates K+ channel function on rat hippocampal interneurons but not CA1 pyramidal neurons.

1997 • 26 citations

Role of concentration and size of intracellular macromolecules in cell volume regulation

1997 • 26 citations

Activation and inactivation of taurine efflux in hyposmotic and isosmotic swelling in cortical astrocytes: Role of ionic strength and cell volume decrease

1999 • 21 citations

Brain Tissue Acidosis: Effects on the Extracellular Concentration of N‐Acetylaspartate

1997 • 21 citations

Alanine uptake activates hepatocellular chloride channels

1997 • 21 citations

Potassium conductance activated during regulatory volume decrease by mudpuppy red blood cells

1996 • 15 citations

Swelling-activated K+ fluxes in vascular endothelial cells: role of intracellular Ca2+

1994 • 11 citations

Protein Kinase Inhibitors Attenuate Cardiac Swelling-induced Amino Acid Release in the Rat

1998 • 10 citations

Regulation of Ca2+-Activated K+ Channels from Rabbit Distal Colon

1997 • 9 citations

Hypotonicity-induced changes in anion permeability of cultured rat brain endothelial cells

1997 • 9 citations

Channels for amino acids and metabolites activated by cell volume regulation.

1994 • 9 citations