A stereochemical concept for the catalytic mechanism of prolylhydroxylase

Superoxide Dismutases

1975 • 1,673 citations

The Biosynthesis of Collagen and Its Disorders

1979 • 1,067 citations

Synthetic oxygen carriers related to biological systems

1979 • 1,001 citations

Handbook of lipid research

1978 • 978 citations

Three-dimensional Fourier Synthesis of Horse Oxyhaemoglobin at 2.8 Å Resolution: The Atomic Model

1968 • 908 citations

Hydroxylation and epoxidation catalyzed by iron-porphine complexes. Oxygen transfer from iodosylbenzene

1979 • 799 citations

The Biosynthesis of Collagen and Its Disorders

1979 • 573 citations

The thermal transition of a non-hydroxylated form of collagen. Evidence for a role for hydroxyproline in stabilizing the triple-helix of collagen

1973 • 563 citations

Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate

1978 • 531 citations

Dioxygen-metal complexes: toward a unified view

1976 • 472 citations

Aliphatic hydroxylation via oxygen rebound. Oxygen transfer catalyzed by iron

1976 • 468 citations

Biochemistry of collagen

1977 • 429 citations

Enzyme-Activated Irreversible Inhibitors

1979 • 420 citations

Spin Transitions in six-coordinate iron(II) complexes

1976 • 388 citations

Synthetic models for the oxygen-binding hemoproteins

1977 • 367 citations

The Primary Structure of Collagen

1976 • 349 citations

Studies on hydroperoxide-dependent substrate hydroxylation by purified liver microsomal cytochrome P-450

1976 • 339 citations

A rapid assay for collagen proline hydroxylase

1966 • 333 citations

Dioxygen ligand in mononuclear Group VIII transition metal complexes

1973 • 325 citations

Cofactor and substrate requirements of collagen proline hydroxylase

1967 • 300 citations

Synthesis of (Pro-Hyp-Gly)n of defined molecular weights Evidence for the stabilization of collagen triple helix by hydroxypyroline

1973 • 291 citations

Synthesis, stereochemistry, and structure-related properties of .alpha.,.beta.,.gamma.,.delta.-tetraphenylporphinatoiron(II)

1975 • 291 citations

Synthesis and extrusion of collagen by freshly isolated cells from chick embryo tendon

1971 • 280 citations

Mechanism of the Prolyl Hydroxylase Reaction

1977 • 260 citations

Mechanism of the Prolyl Hydroxylase Reaction

1977 • 247 citations

Introduction of fluorine into organic molecules: why and how

1978 • 230 citations

Mechanism of epoxidation of olefins by covalent peroxides of molybdenum(VI)

1972 • 228 citations

Structure of horse carbonmonoxyhaemoglobin

1976 • 228 citations

Inorganic oxygen carriers as models for biological systems

1976 • 220 citations

Directed Valence

1940 • 215 citations

The role of ascorbate in the prolyl hydroxylase reaction

1978 • 211 citations

Structure of 18S and 14S acetylcholinesterase. Identification of collagen-like subunits that are linked by disulfide bonds to catalytic subunits

1977 • 204 citations

Hydroxyproline stabilizes the triple helix of chick tendon collagen

1973 • 201 citations

Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase.

1978 • 189 citations

A hypothesis on the role of hydroxyproline in stabilizing collagen structure

1973 • 186 citations

Preparation and characterization of an oxoporphinatochromium(V) complex

1979 • 183 citations

Coordination and catalysis

1976 • 182 citations

Self-catalyzed inactivation of hepatic cytochrome P-450 by ethynyl substrates.

1980 • 178 citations

Sodium periodate, sodium chlorite, organic hydroperoxides, and H2O2 as hydroxylating agents in steroid hydroxylation reactions catalyzed by partially purified cytochrome P-450

1975 • 168 citations

Replacement of proline by azetidine-2-carboxylic acid during biosynthesis of protein

1963 • 165 citations

Structure of oxymyoglobin

1978 • 163 citations

Activation of molecular oxygen: rhodium-catalyzed oxidation of olefins

1978 • 143 citations

The vitamin K-dependent synthesis of gamma-carboxyglutamic acid by bone microsomes.

1978 • 141 citations

Inflammation, Immunity, and Hypersensitivity

1971 • 140 citations

Electronic spectra of metal-dioxygen complexes

1978 • 137 citations

Incorporation of proline analogues into collagen polypeptides Effects on the production of extracellular procollagen and on the stability of the triple-helical structure of the molecule

1974 • 134 citations

Biosynthesis of abnormal collagens with amino acid analogues

1969 • 134 citations

Reactions of peroxobis(triphenylphosphine) platinum (II) and analogs with with carbon dioxide, carbon disulfide, and other unsaturated molecules

1970 • 129 citations

Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450

1977 • 126 citations

The enzymic conversion of 4-fluorophenylalanine to tyrosine

1961 • 124 citations

Biosynthesis of the First Component of Complement by Human and Guinea Pig Peritoneal Macrophages: Evidence for an Independent Production of the C1 Subunits

1978 • 124 citations

Stereospecific aliphatic hydroxylation by iron-hydrogen peroxide. Evidence for a stepwise process

1976 • 122 citations

Influence of chelating agents on the biosynthesis of collagen

1965 • 119 citations

Reaction of iron(III) porphyrins and iodosoxylene. The active oxene complex of cytochrome P-450

1979 • 118 citations

Synthesis of elastin and procollagen by cells from embryonic aorta

1976 • 114 citations

Progress in bioorganic chemistry

1971 • 112 citations

Effects of the stereo-configuration of the hydroxyl group in 4-hydroxyproline on the triple-helical structures formed by homogeneous peptides resembling collagen

1976 • 104 citations

Rheumatoid synovitis. An extravascular immune complex disease

1974 • 104 citations

Activities of prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase in the liver of rats with hepatic injury

1974 • 92 citations

Development of mouse limb buds in organ culture: Chondrogenesis in the presence of a proline analog, l-azetidine-2-carboxylic acid

1972 • 91 citations

Stereospecific aliphatic hydroxylation by an iron-based oxidant

1974 • 89 citations

Semiempirical calculations of model oxyheme: variation of calculated electromagnetic properties with electronic configuration and oxygen geometry

1977 • 83 citations

Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct

1978 • 80 citations

Incorporation of cis- and trans-4-Fluoro-L-prolines into Proteins and Hydroxylation of the trans Isomer During Collagen Biosynthesis^*

1965 • 79 citations

Oxygen-18 studies on the conversion of proline to collagen hydroxyproline

1963 • 79 citations

Incorporation of 3,4-Dehydroproline into Protocollagen and Collagen

1970 • 77 citations

Intracellular enzymes of collagen biosynthesis in rat liver as a function of age and in hepatic injury induced by dimethylnitrosamine. Purification of rat prolyl hydroxylase and comparison of changes in prolyl hydroxylase activity with changes in immunoreactive prolyl hydroxylase

1976 • 77 citations

Destruction of cytochrome P-450 by 2-isopropyl-4-pentenamide and methyl 2-isopropyl-4-pentenoate: Mass spectrometric characterization of prosthetic heme adducts and nonparticipation of epoxide metabolites

1979 • 72 citations

Biosynthesis of abnormal collagens with amino acid analogues. II. Inability of cartilage cells to extrude collagen polypeptides containing L-azetidine-2-carboxylic acid or cis-4-fluoro-L-proline.

1969 • 70 citations

A theoretical investigation of the magnetic and ground-state properties of model oxyhemoglobin complexes

1980 • 70 citations

Inhibition of Liver Fibrosis by L-Azetidine-2-Carboxylic Acid in Rats Treated with Carbon Tetrachloride

1973 • 70 citations

Iodosylbenzene derivatives as oxygen donors in cytochrome P-450 catalyzed steroid hydroxylations

1979 • 68 citations

The Preparation of cis- and trans-4-H³-L-Prolines and Their Use in Studying the Mechanism of Enzymatic Hydroxylation in Chick Embryos

1964 • 67 citations

Structural studies on a glycoprotein isolated from alveoli of patients with alveolar proteinosis

1976 • 67 citations

Mechanisms of zinc ion catalysis in small molecules and enzymes

2007 • 66 citations

Some Solvent and Structural Effects in Free Radical Chlorination¹

1959 • 63 citations

Biosynthesis of abnormal collagens with amino acid analogues

1969 • 61 citations

Non-heme iron dioxygenases structure and mechanism

1980 • 60 citations

Conformational Studies of Oligopeptides Containing Proline and Glycine

1977 • 59 citations

Prevention of Collagen Deposition Following Pulmonary Oxygen Toxicity in the Rat by Cis-4-Hydroxy-l-Proline

1980 • 57 citations

Hydroxylation of alkyl and halogen substituted anilines and acetanilides by microsomal hydroxylases

1968 • 57 citations

Positive Halogen Compounds. II. Radical Chlorination of Substituted Hydrocarbons with t-Butyl Hypochlorite¹

1960 • 56 citations

Oxidative cleavage of .alpha.-keto, .alpha.-hydroxy, and .alpha.-halo ketones, esters, and carboxylic acids by superoxide

1976 • 55 citations

Purification and partial characterization of the two nonidentical subunits of prolyl hydroxylase.

1979 • 55 citations

Simultaneous incorporation of 18O into succinate and hydroxyproline catalyzed by collagen proline hydroxylase

1971 • 53 citations

Oxygenation of 2,6-di--butyl-4-alkylphenols catalyzed by cobalt(II) Schiff's base complexes

1974 • 53 citations

Mechanism of .alpha.-ketoglutarate oxidation in coupled enzymic oxygenations

1969 • 52 citations

Partial reaction of prolyl hydroxylase. (Gly-PRO-Ala)n stimulates alpha-ketoglutarate decarboxylation without prolyl hydroxylation.

1978 • 51 citations

Oxotransition metal oxidants as mimics for the action of mixed-function oxygenases. "NIH shift" with chromyl reagents

1971 • 49 citations

The Mechanism of Action of Cytochrome P-450. Occurrence of the 'NIH Shift' during Hydroperoxide-Dependent Aromatic Hydroxylations

1978 • 47 citations

Mechanism of the Wolff rearrangement. 6. Ab initio molecular orbital calculations on the thermodynamic and kinetic stability of the oxirene molecule

1976 • 45 citations

28. Free-radical substitution in aliphatic compounds. Part II. Halogenation of the n-butyl halides

1960 • 44 citations

The Covalent Structure of Calf Skin Type III Collagen. I. The Amino Acid Sequence of the Amino Terminal Region of the αl(III) Chain (Position 1-222)

1979 • 42 citations

The Mixed Function Oxygenation of 4-Halogenoacetanilides in Rat Liver Microsomes and Model Systems

1968 • 42 citations

Isomer Distribution in the Sulfuryl Chloride Chlorination of the 1-Chlorobutanes and Related Compounds; the Inductive Effect in Free Radical Substitutions¹

1955 • 41 citations

The hydroxylation of alkanes and alkyl chains

1977 • 39 citations

α-Ketoglutarate dependent dioxygenases: A mechanism for prolyl hydroxylase action

1979 • 38 citations

Involvement of superoxide in the prolyl and lysyl hydroxylase reactions

1979 • 38 citations

Incorporation of proline analogs into procollagen

1977 • 38 citations

Assigning oxidation states to some metal dioxygen complexes of biological interest

1979 • 38 citations

Reaction of singlet oxygen with .alpha.-ketocarboxylic acids. Oxidative decarboxylation and peroxyacid formation

1976 • 38 citations

The binding of 18S acetylcholinesterase to sphingomyelin and the role of the collagen-like tail

1977 • 37 citations

71. Preparation and electronic spectra of some tetrahedral complexes of iron(II)

1965 • 37 citations

Electronic structure and electric field gradients in oxyhemoglobin and -cytochrome P-450 model compounds

1975 • 36 citations

Hydralazine-induced disturbances in collagen biosynthesis

1972 • 35 citations

Binding of a Metyrapone Spin Label to Microsomal Cytochrome P‐450

1976 • 34 citations

α‐Ketoglutarate in biological hydroxylations

1968 • 33 citations

Reversible inhibition of C1q release from guinea pig macrophages by 2,2′‐dipyridyl

1978 • 33 citations

¹³C nuclear magnetic resonance study of the cis-trans isomerism in X-Pro-Pro tripeptides

1978 • 32 citations

Studies with proline-3,4-H3 on the hydroxylation of proline during collagen synthesis in chick embryos

1964 • 32 citations

Evidence for a thyroid peroxidase associated “active iodine” species

1978 • 31 citations

Inhibition of hydroxyproline synthesis by palladium ions

1976 • 31 citations

Electronic structure and spectra of tetrahalogenoferrates (II)

1963 • 29 citations

Hydroxylation of proline in polytripeptide models of collagen: stereochemistry of polytripeptide-prolyl hydroxylase interaction

1978 • 28 citations

The electronic structure of peracids. Functional models for cytochrome p-450

1977 • 28 citations

BIOCHEMICAL STUDIES ON CYTOCHROME P‐450 SOLUBILIZED FROM LIVER MICROSOMES: PARTIAL PURIFICATION AND MECHANISM OF CATALYSIS*

1973 • 27 citations

Conformations and electronic properties of alkyl peroxides, alkylperoxy radicals and alkoxy radicals

1977 • 24 citations

Evidence that C1q, a Subcomponent of the First Component of Complement, is an Fc Receptor of Peritoneal and Alveolar Macrophages

1980 • 24 citations

Protocollagen proline hydroxylase in isolated rat liver cells

1972 • 23 citations

Mechanism of base-catalyzed isomerization and disproportionation of trihalobenzenes

1971 • 23 citations

Basement membrane biosynthesis secretion without deposition of underhydroxylated basement membrane collagen by parietal yolk sacs

1978 • 22 citations

Studies on enzymes of collagen biosynthesis and the synthesis of hydroxyproline in macrophages and mast cells

1979 • 22 citations

Immunological Cross‐Reactivity between Electric‐Eel Acetylcholinesterase and Rat‐Tail‐Tendon Collagen

1979 • 22 citations

Investigation of Rapid Proton Exchange by Proton Magnetic Resonance

1970 • 21 citations

Solid-State and Solution Conformation of N-tert-Butyloxycarbonyl-L-prolylglycine

1977 • 20 citations

The hydroxylation of proline to hydroxyproline during the synthesis of collagen in chick embryos

1962 • 20 citations

Quantum chemical study of the mechanism of collagen proline hydroxylation

1973 • 20 citations

The in vivo inhibition of collagen synthesis and the reduction of prolyl hydroxylase activity by 3,4-dehydroproline

1976 • 20 citations

Dioxygen fixation. Oxene transfer in the reaction of singlet dioxygen with .alpha.-keto acids

1978 • 19 citations

l-3,4-Dehydroproline analogs of bradykinin

1978 • 19 citations

CRP, immunologically cross-reacting protein of prolyl hydroxylase. Its role in assembly of active prolyl hydroxylase and cellular localization in L-929 fibroblasts

1980 • 19 citations

Über die Bildung von Oxirenen aus cyclischen α‐Diazoketonen

1978 • 19 citations

A Molecular Orbital Calculation of Chemically Interacting Systems. Interaction between Two Radicals

1978 • 18 citations

Interference with thyroid histogenesis by inhibitors of collagen synthesis.

1977 • 17 citations

Inhibition of tropoelastin secretion by incorporation of dl-3,4-dehydroproline

1977 • 17 citations

The NIH shift of deuterium during the oxidation of aromatic compounds by iron perchlorate and hydrogen peroxide in acetonitrile

1978 • 16 citations

α‐Oxocarbene‐Oxirene Isomerization: Photolysis of [1‐¹³C]‐2‐Diazo‐1‐phenyl‐1‐propanone and [2‐¹³C]‐1‐Diazo‐1‐phenyl‐2‐propanone

1977 • 15 citations

Oxygen-18 exchange studies on vanadate (V10O286-) in aqueous media

1974 • 15 citations

Radical brominations of some chloroalkanes. Evidence for anchimeric assistance by neighboring chlorine

1978 • 11 citations

Studies on the effect of l-3,4-dehydroproline on collagen synthesis by chick embryo polysemes

1976 • 10 citations

Perturbation molecular orbital treatment of free-radical hydrogen-abstraction reactions

1978 • 10 citations

Liver collagen hydroxylation in murine schistosomiasis

1978 • 10 citations

Prolyl hydroxylase in platelets

1976 • 9 citations

Inhibition of Human Prolyl Hydroxylase as Common Biochemical Denominator of the Non-Sedative Effects of Thalidomide in Man

1977 • 9 citations

New evidence for glutamic acid as an iron ligand in hemerythrin

1978 • 8 citations

Studies on the effect of 3,4-dehydroproline on collagen metabolism in carbon tetrachloride-induced hepatic fibrosis

1977 • 8 citations

Prolyl hydroxylase in pulmonary alveolar macrophages

1977 • 6 citations

Selective inhibition of collagen synthesis by d-penicillamine in carrageenin-induced inflammation in rats

1979 • 5 citations

Molecular-orbital study of hydroxylation of collagenous proline and lysine

1971 • 3 citations