The Biosynthesis of Collagen and Its Disorders

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

The Pathogenesis of Atherosclerosis

1976 • 2,000 citations

The Role of Polyprenol-Linked Sugars in Glycoprotein Synthesis

1976 • 680 citations

Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST

1974 • 545 citations

Biochemical characteristics and biological significance of the genetically-distinct collagens

1976 • 468 citations

Biosynthesis of Procollagen

1978 • 452 citations

Platelet Physiology and Abnormalities of Platelet Function

1975 • 444 citations

Patients with Ehlers-Danlos syndrome type IV lack type III collagen.

1975 • 421 citations

A Heritable Disorder of Connective Tissue

1972 • 412 citations

SYNTHESIS, MIGRATION, AND RELEASE OF PRECURSOR COLLAGEN BY ODONTOBLASTS AS VISUALIZED BY RADIOAUTOGRAPHY AFTER [3H]PROLINE ADMINISTRATION

1974 • 376 citations

Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacity.

1976 • 355 citations

The Primary Structure of Collagen

1976 • 349 citations

Physicochemical characterization and molecular organization of the collagen A and B chains

1978 • 347 citations

Vitamin A-containing lipocytes and formation of type III collagen in liver injury.

1976 • 346 citations

Biological significance of the intermolecular crosslinks of collagen

1974 • 346 citations

Nature of the Collagenous Protein in a Tumor Basement Membrane

1978 • 337 citations

The progeny of rabbit articular chondrocytes synthesize collagen types I and III and type I trimer, but not type II. Verifications by cyanogen bromide peptide analysis

1977 • 319 citations

Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts.

1977 • 309 citations

Characterization of the collagen of human hypertrophic and normal scars

1975 • 296 citations

Correlation of procollagen mRNA levels in normal and transformed chick embryo fibroblasts with different rates of procollagen synthesis

1978 • 292 citations

Inhibition of Collagen Secretion from Bone and Cultured Fibroblasts by Microtubular Disruptive Drugs

1972 • 266 citations

Collagen polymorphism in idiopathic chronic pulmonary fibrosis.

1976 • 264 citations

Mechanism of the Prolyl Hydroxylase Reaction

1977 • 260 citations

Defect in Conversion of Procollagen to Collagen in a Form of Ehlers-Danlos Syndrome

1973 • 257 citations

The Biosynthesis of Collagen

1972 • 235 citations

Procollagen Peptidase: An Enzyme Excising the Coordination Peptides of Procollagen

1971 • 232 citations

The biochemistry of complement

1978 • 223 citations

Simultaneous synthesis of types I and III collagen by fibroblasts in culture.

1976 • 219 citations

Degradation of newly synthesized collagen.

1978 • 217 citations

Intracellular Steps in the Biosynthesis of Collagen

1976 • 208 citations

Structure of 18S and 14S acetylcholinesterase. Identification of collagen-like subunits that are linked by disulfide bonds to catalytic subunits

1977 • 204 citations

Time lag in the secretion of collagen by matrix-free tendon cells and inhibition of the secretory process by colchicine and vinblastine

1972 • 197 citations

Microtubules in Transcellular Movement of Procollagen

1972 • 194 citations

Abnormal collagen metabolism in cultured cells in osteogenesis imperfecta.

1975 • 189 citations

Effects of colchicine on collagenase in cultures of rheumatoid synovium

1971 • 189 citations

Impaired conversion of procollagen to collagen by fibroblasts and bone treated with tunicamycin, an inhibitor of protein glycosylation.

1977 • 183 citations

Differences in Collagen Metabolism between Normal and Osteoarthritic Human Articular Cartilage

1973 • 168 citations

Collagen–mineral axial relationship in calcified turkey leg tendon by X-ray and neutron diffraction

1977 • 166 citations

A NEW CHONDRODYSTROPHIC MUTANT IN MICE

1971 • 164 citations

A Collagen Defect in Homocystinuria

1973 • 163 citations

Immunofluorescent localization of collagen types I, II, and III in the embryonic chick eye

1977 • 159 citations

Lysyl-Protocollagen Hydroxylase Deficiency in Fibroblasts from Siblings with Hydroxylysine-Deficient Collagen

1972 • 157 citations

Synthesis of types I and III procollagen and collagen by monkey aortic smooth muscle cells in vitro

1977 • 152 citations

Defects In The Biochemistry Of Collagen In Diseases Of Connective Tissue

1976 • 147 citations

Connective tissue amine oxidase II. Purification and partial characterization of lysyl oxidase from chick aorta

1974 • 146 citations

The collagenous component of lens basement membrane. The isolation and characterization of an alpha chain size collagenous peptide and its relationship to newly synthesized lens components.

1978 • 144 citations

Altered Relation of Two Collagen Types in Osteogenesis Imperfecta

1977 • 143 citations

A hereditary dysplasia of collagen tissues in sheep

1974 • 143 citations

Incorporation of proline analogues into collagen polypeptides Effects on the production of extracellular procollagen and on the stability of the triple-helical structure of the molecule

1974 • 134 citations

Synthesis of two collagen types by embryonic chick corneal epithelium in vitro.

1977 • 134 citations

Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation.

1977 • 133 citations

BIOSYNTHESIS AND MATURATION OF SKIN COLLAGEN IN SCLERODERMA, AND EFFECT OF D-PENICILLAMINE

1974 • 130 citations

Purification and characterization of a peptide from the carboxy-terminal region of chick tendon procollagen type I

1977 • 130 citations

Separate amino and carboxyl procollagen peptidases in chick embryo tendon.

1979 • 129 citations

Evidence that fibronectin is the collagen receptor on platelet membranes.

1978 • 129 citations

Increase in type I and type III collagens in human alcoholic liver cirrhosis.

1976 • 125 citations

Three Conformationally Distinct Domains in the Amino-Terminal Segment of Type III Procollagen and Its Rapid Triple Helix Coil Transition

1978 • 123 citations

Lysyl Oxidase Deficiency in Ehlers–Danlos Syndrome Type V

1975 • 122 citations

Partial purification and characterization of a neutral protease which cleaves the N-terminal propeptides from procollagen

1978 • 122 citations

The stimulation of collagen secretion by ascorbate as a result of increased proline hydroxylation in chick embryo fibroblasts

1975 • 121 citations

Identification of collagen α1(I) trimer in embryonic chick tendons and calvaria

1977 • 120 citations

Collagen heterogeneity within different growth regions of long bones of rachitic and nonrachitic chicks

1972 • 118 citations

Amino-terminal extensions on skin collagen from sheep with a genetic defect in conversion of procollagen into collagen

1976 • 112 citations

Construction and characterization of a 2.5-kilobase procollagen clone.

1978 • 107 citations

Osteogenesis imperfecta congenita: evidence for a generalized molecular disorder of collagen.

1977 • 106 citations

Collagen Synthesis: Localization of Prolyl Hydroxylase in Tendon Cells Detected with Ferritin-Labeled Antibodies

1973 • 105 citations

The embryonic rat parietal yolk sac. The role of the parietal endoderm in the biosynthesis of basement membrane collagen and glycoprotein in vitro.

1975 • 103 citations

Identification of collagen α1 (I) trimer and normal type I collagen in a polyoma virus-induced mouse tumor

1977 • 101 citations

Collagen cross-linking. Purification and substrate specificity of lysyl oxidase.

1976 • 101 citations

Biochemistry of the Renal Glomerular Basement Membrane and Its Alterations in Diabetes Mellitus

1973 • 98 citations

Decreased lysyl oxidase activity in the aneurysm-prone, mottled mouse.

1977 • 98 citations

Effect of colchicine on collagen, albumin and transferrin synthesis by cirrhotic rat liver slices

1975 • 95 citations

The Biosynthesis of Basement Membrane Collagen in Embryonic Chick Lens

1973 • 95 citations

Age-related variations in hydroxylation of lysine and proline in collagen

1974 • 92 citations

Kinetics for the secretion of procollagen by freshly isolated tendon cells

1977 • 89 citations

Reducible Crosslinks in Hydroxylysine-Deficient Collagens of a Heritable Disorder of Connective Tissue

1972 • 88 citations

Hydroxylysine-Deficient Skin Collagen in a Patient with a Form of the Ehlers-Danlos Syndrome

1974 • 86 citations

Three new α-chains of collagen from a non-basement membrane source

1978 • 84 citations

Protocollagen lysine hydroxylase. Hydroxylation of synthetic peptides and the stoichiometric decarboxylation of α-ketoglutarate

1972 • 83 citations

Ferritin-Conjugated Antibodies Used for Labeling of Organelles Involved in the Cellular Synthesis and Transport of Procollagen

1974 • 81 citations

Intracellular enzymes of collagen biosynthesis in rat liver as a function of age and in hepatic injury induced by dimethylnitrosamine. Changes in prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase activities

1976 • 79 citations

Calf Tendon Procollagen Peptidase: Its Purification and Endopeptidase Mode of Action

1974 • 79 citations

Collagen structure: Evidence for a helical organization of the collagen fibril

1977 • 78 citations

Connective tissue synthesis by cultured scleroderma fibroblasts. I. In vitro collagen synthesis by normal and scleroderma dermal fibroblasts

1976 • 75 citations

Biochemical and ultrastructural studies of collagen and proteochondroitin sulfate in normal and nanomelic cartilage

1976 • 75 citations

Studies on the assembly of the rat lens capsule. Biosynthesis and partial characterization of the collagenous components

1978 • 74 citations

Collagen biosynthesis. Characterization of subcellular fractions from embryonic chick fibroblasts and the intracellular localization of protocollagen prolyl and protocollagen lysyl hydroxylases

1974 • 73 citations

Pharmacology of fibrosis: Definitions, limits and perspectives

1975 • 72 citations

Synthesis of collagens Types I and III by pig medial smooth muscle cells in culture

1976 • 71 citations

Characterization of the Amino-Terminal Segment in Type III Procollagen

1976 • 71 citations

Biosynthesis of cartilage procollagen. Influence of chain association and hydroxylation of prolyl residues on the folding of the polypeptides into the triple-helical conformation

1974 • 70 citations

Characterization of Collagen and Its Precursors Synthesized by Rabbit‐Articular‐Cartilage Cells in Various Culture Systems

1976 • 70 citations

Procollagen peptidase: Its mode of action on the native substrate

1975 • 69 citations

Procollagen assembly and secretion in embryonic chick bone.

1975 • 68 citations

Collagen of Marfan Syndrome is Abnormally Soluble

1973 • 68 citations

Properties of highly purified lysyl oxidase from embryonic chick cartilage

1976 • 66 citations

Collagen biosynthesis enzymes in serum and hepatic tissue in liver disease

1979 • 66 citations

Sequence position of 3-hydroxyproline in basement membrane collagen. Isolation of glycyl-3-hydroxyprolyl-4-hydroxyproline from swine kidney.

1975 • 66 citations

Studies on the glycosylation of hydroxylysine residues during collagen biosynthesis and the subcellular localization of collagen galactosyltransferase and collagen glucosyltransferase in tendon and cartilage cells

1975 • 66 citations

Ocular Ehlers-Danlos Syndrome With Normal Lysyl Hydroxylase Activity

1976 • 66 citations

Biosynthesis of type II collagen. Removal of amino- and carboxy-terminal extensions from procollagen synthesized by chick embryo cartilage cells

1977 • 66 citations

Assignment of a type I collagen structural gene to human chromosome 7

1978 • 66 citations

Ascorbate increases the synthesis of procollagen hydroxyproline by cultured fibroblasts from chick embryo tendons without activation or prolyl hydroxylase

1975 • 66 citations

Characterization of type III procollagen from chick embryo blood vessels.

1979 • 65 citations

Bone collagen metabolism in vitamin D deficiency (Short Communication)

1973 • 64 citations

Radioimmunoassay of Procollagen in Serum of Patients with Paget's Disease of Bone

1976 • 64 citations

Procollagen and collagen produced by a teratocarcinoma-derived cell line, TSD4: Evidence for a new molecular form of collagen

1977 • 63 citations

Glucocorticoids selectively decrease the synthesis of hydroxylated collagen peptides.

1978 • 63 citations

Failure of cultured chick embryo fibroblasts to incorporate collagen into their extracellular matrix when transformed by Rous sarcoma virus. An effect of transformation but not of virus production.

1977 • 62 citations

Prolyl 3‐Hydroxylase: Partial Characterization of the Enzyme from Rat Kidney Cortex

1977 • 62 citations

Construction of a recombinant bacterial plasmid containing a chick pro-alpha2 collagen gene sequence.

1978 • 61 citations

The biosynthesis of procollagen.

1976 • 61 citations

Termination of procollagen chain synthesis by puromycin. Evidence that assembly and secretion require a COOH-terminal extension.

1976 • 61 citations

Assay of protocollagen lysyl hydroxylase activity in the skin of human subjects and changes in the activity with age

1973 • 60 citations

The synthesis of underhydroxylated collagen by 3T6 mouse fibroblasts in culture

1972 • 60 citations

NH2-terminal sequence of the chick proalpha1(I) chain synthesized in the reticulocyte lysate system. Evidence for a transient hydrophobic leader sequence.

1979 • 60 citations

Prolyl hydroxylase and an immunologically related protein in mammalian tissues

1974 • 60 citations

Increased collagen synthesis in Kirsten sarcoma virus-transformed BALB 3T3 cells grown in the presence of dibutyryl cyclic AMP

1974 • 58 citations

Collagen synthesized and modified by aging fibroblasts in culture

1975 • 58 citations

Abnormal properties of collagen lysyl hydroxylase from skin fibroblasts of siblings with hydroxylysine-deficient collagen.

1976 • 57 citations

Molecular packing of collagen: Three-dimensional analysis of electrostatic interactions

1976 • 56 citations

Genetics of the connective tissue proteins: Assignment of the gene for human type I procollagen to chromosome 17 by analysis of cell hybrids and microcell hybrids

1977 • 56 citations

Segment-long-spacing aggregates and isolation of COOH-terminal peptides from type I procollagen.

1976 • 56 citations

Separation of prolyl 3-hydroxylase and 4-hydroxylase activities and the 4-hydroxyproline requirement for synthesis of 3-hydroxyproline

1977 • 56 citations

Collagen proline hydroxylase activity and 35S sulphate uptake in human liver biopsies

1974 • 56 citations

Effect of cortisol acetate on collagen biosynthesis and on the activities of prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase in chick-embryo tendon cells

1977 • 55 citations

Purification and partial characterization of the two nonidentical subunits of prolyl hydroxylase.

1979 • 55 citations

Synthesis and secretion of under-hydroxylated procollagen at various temperatures by cells subject to temporary anoxia

1974 • 55 citations

Translation of collagen messenger RNA in a cell-free system derived from wheat germ

1976 • 54 citations

Hepatic collagen proline hydroxylase activity in alcoholic liver disease

1976 • 54 citations

Presence of type III collagen in bone from a patient with osteogenesis imperfecta

1977 • 52 citations

Intermediates in the Conversion of Procollagen to Collagen

1977 • 52 citations

Hydroxylation of lysine and glycosylation of hydroxylysine during collagen biosynthesis in isolated chick-embryo cartilage cells

1976 • 52 citations

The metabolic requirements for transcellular movement and secretion of collagen.

1975 • 52 citations

Synthesis of collagen by chondrocytes in suspension culture: Modulation by calcium, 3′:5′-cyclic AMP, and prostaglandins

1977 • 51 citations

Heterogeneity of Pepsin-Solubilized Human Glomerular Basement Membrane Collagen

1978 • 50 citations

Characterization of collagen precursors found in rat skin and rat bone

1977 • 50 citations

Biosynthesis of type I and III collagens by cultured smooth muscle cells from human aorta.

1977 • 49 citations

Rate of helix formation by intracellular procollagen and protocollagen. Evidence for a role for disulfide bons

1973 • 49 citations

Immunoreactive prolyl hydroxylase in human skin, serum and synovial fluid: changes in the content and components with age

1977 • 49 citations

The disulphide-bonded nature of procollagen and the role of the extension peptides in the assembly of the molecule

1977 • 48 citations

Cross-Linking

1976 • 48 citations

Prolyl Hydroxylase Activity in Normal and Diseased Human Liver

1976 • 47 citations

Evidence for an Amino-Terminal Extension in High-Molecular-Weight Collagens from Mature Bovine Skin

1973 • 45 citations

Decreased thermal stability of collagens containing analogs of proline or lysine

1974 • 45 citations

The stability of collagen cross-links when derived from hydroxylysyl residues

1973 • 45 citations

Physical properties of the amino-terminal precursor-specific portion of type I procollagen

1977 • 44 citations

Age-related changes in human skin collagen galactosyltransferase and collagen glucosyltransferase activities

1977 • 44 citations

Effect of L-3,4-dehydroproline on collagen synthesis and prolyl hydroxylase activity in mammalian cell cultures.

1976 • 43 citations

Collagen glucosyltransferase activity in human serum

1977 • 42 citations

Isolation of α-amino adipic acid from mature dermal collagen and elastin. Evidence for an oxidative pathway in the maturation of collagen and elastin

1977 • 42 citations

Effects of lysosomal enzymes on the type of collagen synthesized by bovine articular cartilage

1973 • 40 citations

Submicrosomal localization of prolyl hydroxylase from chick embryo limb bone.

1976 • 40 citations

Experimental Esophageal Lye Burns

1973 • 40 citations

The intracellular location of the glycosylation of hydroxylysine of collagen

1975 • 40 citations

Effect of prednisolone on the activities of the intracellular enzymes of collagen biosynthesis in rat liver and skin

1977 • 39 citations

Affinity Chromatography of Collagen Glycosyltransferases on Collagen Linked to Agarose

1976 • 38 citations

Serum immunoreactive prolyl hydroxylase in liver disease

1977 • 37 citations

Localization and partial composition of the oligosaccharide units on the propeptide extensions of type I procollagen.

1978 • 36 citations

Translation of chick calvarial procollagen messenger RNAs by a messenger RNA dependent reticulocyte lysate

1978 • 35 citations

Homology between a prolyl hydroxylase subunit and a tissue protein that crossreacts immunologically with the enzyme.

1977 • 34 citations

Native collagen is not a substrate for the collagen glucosyltransferase of platelets

1976 • 34 citations

Comparison of the cyanogen bromide peptides of insoluble guinea-pig skin and scar collagen

1975 • 34 citations

Triple-helix formation on ribosome-bound nascent chains of procollagen: deuterium-hydrogen exchange studies.

1977 • 34 citations

Colchicine in the treatment of scleroderma.

1977 • 34 citations

The synthesis and secretion of cartilage procollagen

1975 • 33 citations

Translation of type I and type II procollagen messengers in a cell‐free system derived from wheat germ

1975 • 33 citations

Isolation of collagen glucosyltransferase as a homogeneous protein from chick embryos

1977 • 32 citations

Time of occurrence of disulfide linking between procollagen chains.

1976 • 31 citations

Collagen lysyl hydroxylation occurs within the cisternae of the rough endoplasmic reticulum

1976 • 30 citations

Hydroxyproline contents and prolyl hydroxylase activities in lungs of rats exposed to low levels of ozone

1976 • 30 citations

Effect of L-azetidine-2-carboxylic acid on glycosylations of collagen in chick-embryo tendon cells

1976 • 30 citations

Affinity chromatography of lysyl hydroxylase on concanavalin A-agarose

1977 • 29 citations

Procollagen polypeptides containing cis-4-hydroxy-l-proline are overglycosylated and secreted as nonhelical pro-γ-chains

1978 • 29 citations

Characterization of the amino‐terminal segment in procollagen pα2 chain from dermatosparactic sheep

1977 • 29 citations

Increased collagen synthesis and the kinetic characteristics of prolyl hydroxylase in tissues of rabbits with experimental arteriosclerosis

1976 • 29 citations

Age-related variations in glycosylation of hydroxylysine in human and rat skin collagens

1975 • 29 citations

Prolyl hydroxylase activity in L-929 fibroblasts incubated with and without ascorbate

1976 • 28 citations

Ascorbate‐independent proline hydroxylation resulting from viral transformation of balb 3T3 cells and unaffected by dibutyryl camp treatment

1976 • 27 citations

Tetramers and Monomers of Prolyl Hydroxylase in Isolated Chick-Embryo Tendon Cells. The Association of Inactive Monomers to Active Tetramers and a Preliminary Characterization of the Intracellular Monomer-Size Protein

1977 • 27 citations

Purification and partial characterization of the type II procollagen synthesized by embryonic cartilage cells

1977 • 26 citations

A new variety of spondyloepiphyseal dysplasia characterized by punctate corneal dystrophy and abnormal dermal collagen fibrils

1978 • 26 citations

Radioimmunoassay for aminoterminal procollagen peptides in liver disease

1978 • 25 citations

An analysis of the association of collagen based on structural models

1976 • 23 citations

Addition of mannose to both the amino- and carboxy-terminal propeptides of type II procollagen occurs without formation of a triple helix

1978 • 23 citations

HERITABLE DISORDERS OF CONNECTIVE TISSUE—Fourth Edition

1974 • 22 citations

Intracellular enzymes of collagen biosynthesis in human platelets

1977 • 22 citations

Studies on the mechanism of reduction of prolyl hydroxylase activity by d,l-3,4 dehydroproline

1978 • 22 citations

Further studies on the effect of the collagen triple-helix formation on the hydroxylation of lysine and the glycosylations of hydroxylysine in chick-embryo tendon and cartilage cells

1977 • 21 citations

X-ray diffraction by collagen tape shows that type I collagen fibrils need not have a three-dimensional lattice

1977 • 21 citations

Comparative studies on collagen glycosylation in chick skin and bone

1977 • 20 citations

Effect of cis-hydroxyproline on collagen and other proteins in skin wounds, granuloma tissue, and liver of mice and rats

1974 • 19 citations

Reduction of collagen biosynthesis in blood vessels and other tissues by reserpine and hypophysectomy

1977 • 18 citations

Collagen metabolism in rat lungs during chronic intermittent exposure to oxygen.

1975 • 18 citations

Secretion of unhydroxylated chick tendon procollagen

1975 • 16 citations

Isolation and hydroxylysine glycoside content of some cyanogen bromide-cleaved fragments of collagen from bovine corneal stroma

1978 • 14 citations

Evidence that the messenger RNA for collagen is monocistronic

1977 • 14 citations

Evidence for the transfer of mannose to the extension peptides of procollagen within the cisternae of the rough endoplasmic reticulum

1978 • 12 citations

Collagen and Elastin in Scleroderma

1974 • 10 citations

Recherche de la fixation subcellulaire de la procollagene-proline-hydroxylase du foie d'embryon de poulet

1976 • 10 citations

Determination of the extent of secondary structure in chick embryo procollagen messenger RNA

1977 • 8 citations

Colchicine: Effects upon urinary hydroxyproline excretion in patients with scleroderma

1975 • 7 citations