Monoclonal Antibody O10 Defines a Conformationally Sensitive Cell-Surface Epitope of Proteolipid Protein (PLP): Evidence that PLP Misfolding Underlies Dysmyelination in Mutant Mice

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: An immunocytological study in the central nervous system

1981 • 1,131 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

The oligodendrocyte and its many cellular processes

1993 • 837 citations

Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins.

1994 • 482 citations

Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus.

1994 • 447 citations

Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein

1985 • 345 citations

Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin.

1987 • 300 citations

Proteins of Myelin

1977 • 281 citations

Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage

1994 • 277 citations

Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene

1994 • 263 citations

Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide-bonded, and fatty acid thioester-linked cysteine residues and implications for the membrane topology of PLP

1992 • 227 citations

Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice.

1994 • 222 citations

Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing.

1986 • 219 citations

Oligodendroglial cell death in jimpy mice: an explanation for the myelin deficit

1986 • 218 citations

Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene

1992 • 212 citations

Developmental expression in central and peripheral nervous system of oligodendrocyte cell surface antigens (O antigens) recognized by monoclonal antibodies

1981 • 189 citations

Proteins of Myelin

1984 • 183 citations

Expression of Thy-1, H-2 and NS-4 cell surface antigens and tetanus toxin receptors in early postnatal and adult mouse cerebellum

1981 • 177 citations

Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse.

1987 • 174 citations

Many naturally occurring mutations of myelin proteolipid protein impair its intracellular transport

1994 • 159 citations

Adhesive properties of proteolipid protein are responsible for the compaction of CNS myelin sheaths

1995 • 152 citations

Genetics of Pelizaeus-Merzbacher Disease

1993 • 137 citations

Structure and molecular arrangement of proteolipid protein of central nervous system myelin.

1984 • 130 citations

The molecular genetics of myelination: An update

1993 • 116 citations

[46] Isolation of myelin from nerve tissue

1974 • 109 citations

Parallel Evolution and Coexpression of the Proteolipid Proteins and Protein Zero in Vertebrate Myelin

1996 • 105 citations

Arrest of proteolipid transport through the Golgi apparatus in Jimpy brain

1987 • 101 citations

Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice.

1990 • 96 citations

Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice

1990 • 85 citations

X-Linked Developmental Defects of Myelination: From Mouse Mutants to Human Genetic Diseases

1996 • 83 citations

Myelin Proteolipid Protein Gene Expression in Jimpy and Jimpy^msdMice

1988 • 82 citations

Dominant-negative action of the jimpy mutation in mice complemented with an autosomal transgene for myelin proteolipid protein.

1995 • 78 citations

Intracellular transport and sorting of the oligodendrocyte transmembrane proteolipid protein

1994 • 77 citations

Structure and Function of Myelin Protein Genes

1991 • 68 citations

A Combination of PLP and DM20 Transgenes Promotes Partial Myelination in the Jimpy Mouse

1994 • 67 citations

Proteolipid protein interactions in transfectants: Implications for myelin assembly

1994 • 62 citations

Effect of the Jimpy Mutation on Expression of Myelin Proteins in Heterozygous and Hemizygous Mouse Brain

1984 • 61 citations

Death of Individual Oligodendrocytes in <i>Jimpy</i> Brain Precedes Expression of Proteolipid Protein

1990 • 60 citations

Ultrastructural features of cultured oligodendrocytes expressing stage-specific cell-surface antigens

1988 • 55 citations

Jimpy Mice: Quantitation of Myelin‐Associated Glycoprotein and Other Proteins

1986 • 48 citations

Proteolipid proteins: structure and genetic expression in normal and myelin-deficient mutant mice.

1989 • 47 citations

Protein Oligomerization In The Endoplasmic Reticulum

1989 • 47 citations

Developmental expression of major myelin protein genes in the CNS of X‐Linked hypomyelinating mutant rumpshaker

1992 • 36 citations

The genetics of myelin

1993 • 35 citations

Oligodendrocyte development and differentiation in the rumpshaker mutation

1993 • 34 citations

Cysteine-108 is an acylation site in myelin proteolipid protein

1990 • 26 citations

Analysis of myelin proteolipid protein and F0ATPase subunit 9 in normal andjimpy CNS

1994 • 15 citations

Stage Specific Antigens on Oligodendrocyte Cell Surfaces

1984 • 13 citations

Identification of thiol groups and a disulfide crosslink site in bovine myelin proteolipid protein

1989 • 13 citations

Isolation and identification of proteolipid proteins injimpy mouse brain

1994 • 13 citations