Locking of hormone in the beta-adrenergic receptor by attack on a sulfhydryl in an associated component.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

The Catalytic and Regulatory Properties of Enzymes

1968 • 603 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 487 citations

Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme.

1978 • 480 citations

GTP-binding proteins in membranes and the control of adenylate cyclase activity.

1977 • 456 citations

Guanosine 5'-O-(2-thiodiphosphate). An inhibitor of adenylate cyclase stimulation by guanine nucleotides and fluoride ions.

1979 • 382 citations

Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP.

1978 • 372 citations

Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor–cyclase coupling

1981 • 322 citations

An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor.

1976 • 318 citations

Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion.

1976 • 240 citations

Binding of (125I)iodohydroxybenzylpindolol to putative beta-adrenergic receptors of rat glioma cells and other cell clones.

1976 • 238 citations

Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system.

1980 • 229 citations

Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-adrenergic receptor.

1977 • 228 citations

Magnesium dependence of agonist binding to adenylate cyclase-coupled hormone receptors.

1978 • 158 citations

The Role of Negative Cooperativity and Half-of-the-Sites Reactivity in Enzyme Regulation

1976 • 158 citations

Membranes and Transport

1982 • 154 citations

A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes.

1980 • 152 citations

Resolution, reconstitution and kinetics of the primary action of a hormone receptor

1980 • 149 citations

Adenyl Cyclase of Rat Parotid Gland

1970 • 149 citations

Guanine nucleotide‐controlled interactions between components of adenylate cyclase

1979 • 144 citations

The role of the guanine nucleotide exchange reaction in the regulation of the beta-adrenergic receptor and in the actions of catecholamines and cholera toxin on adenylate cyclase in turkey erythrocyte membranes.

1980 • 126 citations

Coupling of hormone receptors to adenylate cyclase of different cells by cell fusion

1977 • 119 citations

Beta adrenergic receptors and adenylate cyclase: products of separate genes?

1976 • 98 citations

Transfer of glucagon receptor from liver membranes to a foreign adenylate cyclase by a membrane fusion procedure

1979 • 89 citations

Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors.

1979 • 83 citations

Efficiency of coupling between the beta adrenergic receptor and adenylate cyclase.

1978 • 53 citations

High performance liquid chromatographic separation and detection of catecholamines and related compounds

1979 • 51 citations

Functional implantation of a solubilized β-adrenergic receptor in the membrane of a cell

1980 • 46 citations

Inactivation of beta-adrenergic receptors by N-ethylmaleimide: permissive role of beta-adrenergic agents in relation to adenylate cyclase activation.

1980 • 46 citations

Inactivation of beta-adrenergic receptors by N-ethylmaleimide in S49 lymphoma cells. Agonist induction of functional receptor heterogeneity.

1980 • 39 citations

Distinction between Two Subpopulations of β₁‐Adrenergic Receptors in Human Adipose Cells

1981 • 39 citations

The β-adrenergic receptor of turkey erythrocyte membranes: Conformational modification by β-adrenergic agonists

1979 • 37 citations

Binding energy and the activation of hormone receptors

1980 • 32 citations

Interaction between beta-adrenergic receptors and guanine nucleotide sites in turkey erythrocyte membranes.

1980 • 28 citations

Hybridization of adenylate cyclase components by membrane fusion and the effect of selective digestion by trypsin.

1980 • 24 citations