Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Homology with human alpha-galactosidase A suggests evolution from a common ancestral gene.

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins

1985 • 1,253 citations

[17] Isolation of microgram quantities of proteins from polyacrylamide gels for amino acid sequence analysis

1983 • 1,115 citations

The human glucocerebrosidase gene and pseudogene: Structure and evolution

1989 • 421 citations

[20] Computer prediction of RNA structure

1989 • 387 citations

Are U4 small nuclear ribonucleoproteins involved in polyadenylation?

1984 • 379 citations

Fabry's disease: enzymatic diagnosis of hemizygotes and heterozygotes. Alpha-galactosidase activities in plasma, serum, urine, and leukocytes.

1973 • 307 citations

The role of the mammalian branchpoint sequence in pre-mRNA splicing.

1988 • 215 citations

Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro.

1989 • 189 citations

Structural organization of the human alpha-galactosidase A gene: further evidence for the absence of a 3' untranslated region.

1988 • 165 citations

Protein Sequence Analysis: Automated Microsequencing

1983 • 163 citations

Nucleotide sequence of the human α-galactosidase A gene

1989 • 146 citations

Neuroaxonal Dystrophy Due to Lysosomal α-N-Acetylgalactosaminidase Deficiency

1989 • 115 citations

Gene encoding the human beta-hexosaminidase beta chain: extensive homology of intron placement in the alpha- and beta-chain genes.

1988 • 115 citations

Affinity purification of alpha-galactosidase A from human spleen, placenta, and plasma with elimination of pyrogen contamination. Properties of the purified splenic enzyme compared to other forms.

1981 • 114 citations

Purification and Properties of Human α-Galactosidases

1972 • 109 citations

Purification and properties of the two major isozymes of alpha-galactosidase from human placenta.

1978 • 95 citations

Human uroporphyrinogen III synthase: molecular cloning, nucleotide sequence, and expression of a full-length cDNA.

1988 • 95 citations

Human arylsulfatase B: MOPAC cloning, nucleotide sequence of a full-length cDNA, and regions of amino acid identity with arylsulfatases A and C

1990 • 76 citations

Biochemical and electrophoretic studies of -galactosidase in normal man, in patients with Fabry's disease, and in Equidae.

1972 • 71 citations

The nucleotide sequence of the yeastMEL1gene

1985 • 66 citations

Fabry disease: isolation of a cDNA clone encoding human alpha-galactosidase A.

1985 • 59 citations

Fabry's disease: evidence for a physically altered -galactosidase.

1972 • 57 citations

Nucleotide sequence of the melA gene, Coding for α-galactosidase inEscherichia coliK-12

1987 • 55 citations

The identification of α-galactosidase B from human liver as an α-acetylgalactosaminidase

1977 • 54 citations

The identity of α-galactosidase B from human liver

1977 • 54 citations

Polymerase-specific differences in the DNA intermediates of frameshift mutagenesis

1989 • 52 citations

α‐N‐acetylgalactosaminidase deficiency, a new lysosomal storage disorder

1988 • 50 citations

Fabry's disease: absence of an -galactosidase isozyme.

1972 • 46 citations

Lipid storage disorders : biological and medical aspects

1988 • 44 citations

Studies on human liver alpha-galactosidases. II. Purification and enzymatic properties of alpha-galactosidase B (alpha-N-acetylgalactosaminidase).

1979 • 43 citations

A method for the rapid detection of urinary glycopeptides in α-N-acetylgalactosaminidase deficiency and other lysosomal storage diseases

1990 • 32 citations

Molecular cloning of a full-length cDNA for human α-N-acetylgalactosaminidase (α-galactosidase B)

1989 • 30 citations

Alpha-N-acetylgalactosaminidase: Isolation, properties and distribution of the human enzyme

1973 • 28 citations

Genetic heterogeneity of α‐galactosidase in fabry's disease

1972 • 27 citations

Localization of a gene for human α-galactosidase B (=N-Acetyl-α-D-Galactosaminidase) on chromosome 22

1978 • 18 citations

Post-translational processing reactions involved in the biosynthesis of lysosomal α-N-acetylgalactosaminidase in cultured human fibroblasts

1983 • 12 citations