Protein Sequence Analysis: Automated Microsequencing

A Protein Sequenator

1967 • 2,826 citations

A gas-liquid solid phase peptide and protein sequenator.

1981 • 2,238 citations

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

1981 • 1,881 citations

[17] Isolation of microgram quantities of proteins from polyacrylamide gels for amino acid sequence analysis

1983 • 1,115 citations

Synthesis of deoxyoligonucleotides on a polymer support

1981 • 870 citations

Micro‐sequence analysis of peptides and proteins using 4‐NN‐dimethylaminoazobenzene 4′‐isothiocyanate/phenylisothiocyanate double coupling method

1978 • 834 citations

Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

1982 • 826 citations

Quantitative procedures for use with the Edman-Begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac

1971 • 679 citations

Rapid analysis of amino acid phenylthiohydantoins by high-performance liquid chromatography

1977 • 645 citations

Acetylcholine Receptor: Complex of Homologous Subunits

1980 • 594 citations

A molecular map of the immune response region from the major histocompatibility complex of the mouse

1982 • 466 citations

Polyquarternary amines prevent peptide loss from sequenators

1978 • 452 citations

Solid‐Phase Edman Degradation

1971 • 426 citations

Regeneration of amino acids from thiazolinones formed in the Edman degradation

1975 • 394 citations

Direct microsequence analysis of polypeptides using an improved sequenator, a nonprotein carrier (Polybrene), and high pressure liquid chromatography

1978 • 382 citations

Separation of large denatured peptides by reverse phase high performance liquid chromatography. Trifluoroacetic acid as a peptide solvent.

1980 • 376 citations

On the Mechanism of the Phenyl Isothiocyanate Degradation of Peptides.

1956 • 320 citations

Advances in the gas chromatographic analysis of amino acid phenyl- and methylthiohydantoins

1972 • 307 citations

Antibodies specific for the carboxy- and amino-terminal regions of simian virus 40 large tumor antigen.

1980 • 262 citations

Chemical synthesis of a polypeptide predicted from nucleotide sequence allows detection of a new retroviral gene product

1980 • 203 citations

Primary structure of a murine transplantation antigen

1981 • 194 citations

Amino Acid Sequence Studies on teil Ribosomal Proteins ofEscherichia coliwith an Improved Sequenator Equipped with an Automatic Conversion Device

1973 • 176 citations

Detection and partial sequence analysis of gastrin mRNA by using an oligodeoxynucleotide probe.

1979 • 163 citations

New Protein Sequenator with Increased Sensitivity

1980 • 162 citations

Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary.

1982 • 137 citations

A device coupled to a modified sequenator for the automated conversion of anilinothiazolinones into PTH amino acids

1976 • 125 citations

Solid‐Phase Sequence Analysis of Polypeptides Eluted from Polyacrylamide Gels

1982 • 80 citations

Amino acid sequence of the NH2-terminal extra piece segments of the precursors of mouse immunoglobulin lambda1-type and kappa-type light chains.

1977 • 80 citations

Structure and evolution of transplantation antigens: partial amino-acid sequences of H-2K and H-2D alloantigens.

1976 • 75 citations

Studies on the primary structure of 14 proteins from the large subunit of escherichia coli ribosomes with an improved protein sequenator and with mass spectrometry

1975 • 74 citations

Solid phase sequencing: A new support for the high sensitivity degradation of peptides and proteins

1975 • 44 citations

High sensitivity automated sequence determination of polypeptides.

1975 • 42 citations

HLA membrane antigens: sequencing by intrinsic radioactivity.

1976 • 35 citations

The decline and fall of protein chemistry?

1978 • 19 citations