Analysis of chromosome 17p13 (p53 locus) alterations in gastric carcinoma cells by dual-color fluorescence in situ hybridization.

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO‐CALLED INTESTINAL‐TYPE CARCINOMA

1965 • 5,842 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Localization of gene for human p53 tumour antigen to band 17p13

1986 • 498 citations

In situ hybridization as a tool to study numerical chromosome aberrations in solid bladder tumors

1988 • 462 citations

Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli

1992 • 335 citations

MULTIPLE GENETIC ALTERATIONS IN DISTAL AND PROXIMAL COLORECTAL CANCER

1989 • 306 citations

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.

1991 • 251 citations

Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis.

1991 • 230 citations

p53 alteration in gastric precancerous lesions.

1994 • 229 citations

Centromeric copy number of chromosome 7 is strongly correlated with tumor grade and labeling index in human bladder cancer.

1991 • 199 citations

Genetics of cancer predisposition.

1987 • 199 citations

p53 Mutation in gastric cancer: A genetic model for carcinogenesis is common to gastric and colorectal cancer

1993 • 195 citations

p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail.

1994 • 183 citations

Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer.

1991 • 140 citations

Deletion of chromosome 17p loci in breast cancer cells detected by fluorescence in situ hybridization.

1992 • 106 citations

Base transitions are the most frequent genetic changes at P53 in gastric cancer.

1993 • 105 citations

High Incidence of p53 Gene Mutation in Human Ovarian Cancer and Its Association with Nuclear Accumulation of p53 Protein and Tumor DNA Aneuploidy

1992 • 101 citations

Isolation and mapping of a polymorphic DNA sequence (pYNZ22) on chromosome 17p [D17S30]

1988 • 93 citations

The clinical significance of p53 aberrations in human tumours

1995 • 93 citations

p53 point mutations in primary human gastric carcinomas

1992 • 80 citations

Physical deletion of the p53 gene in bladder cancer. Detection by fluorescence in situ hybridization.

1994 • 69 citations

p53 gene mutations in human gastric cancer: wild-type p53 but not mutant p53 suppresses growth of human gastric cancer cells.

1992 • 65 citations

p53 gene mutations in gastric adenomas

1993 • 62 citations

Clonal allele loss in gastrointestinal cancers

1989 • 55 citations

Loss of heterozygosity and K-ras gene mutations in gastric cancer

1993 • 53 citations

Frequency and spectrum of p53 mutations in gastric cancer ? a molecular genetic and immunohistochemical study

1995 • 35 citations

Infrequent loss of chromosomal heterozygosity in human stomach cancer.

1988 • 34 citations

Relation between the occurrence of K-ras gene point mutations and genotypes of polymorphic N-acetyltransferase in human colorectal carcinomas

1994 • 26 citations

Expression of p53 and flow cytometric DNA analysis of isolated neoplastic glands of the stomach: an application of the gland isolation method

1995 • 6 citations