Patterns of epidermal growth factor receptor amplification in malignant gliomas.

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

1987 • 843 citations

Identification of an Amplified, Highly Expressed Gene in a Human Glioma

1987 • 671 citations

Clonal genomic alterations in glioma malignancy stages.

1988 • 520 citations

p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.

1992 • 297 citations

Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.

1988 • 259 citations

Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification.

1994 • 255 citations

p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency.

1992 • 248 citations

Cytogenetics of human brain tumors

1990 • 217 citations

Amplification of the epidermal‐growth‐factor‐receptor gene correlates with different growth behaviour in human glioblastoma

1994 • 204 citations

Amplification of Epidermal Growth Factor Receptor Gene in Gliomas: Histopathology and Prognosis

1992 • 201 citations

Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas.

1992 • 187 citations

Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity.

1992 • 175 citations

Allelotype of human malignant astrocytoma.

1990 • 163 citations

Highly anaplastic astrocytoma: A review of 357 patients treated between 1977 and 1989

1992 • 118 citations

An immunohistochemical assessment of cellular proliferation markers in head and neck squamous cell cancers

1990 • 109 citations

EGF receptor amplification and expression in human brain tumours

1992 • 108 citations

Relationship between epidermal growth factor receptor status and various prognostic factors in human breast cancer

1990 • 100 citations

Epidermal‐growth‐factor‐receptor expression is associated with rapid tumor proliferation in bladder cancer

1994 • 95 citations

Detection of multiple gains and losses of genetic material in ten glioma cell lines by comparative genomic hybridization

1995 • 85 citations

Relationships between Ki-67 labelling index, amplification of the epidermal growth factor receptor gene, and prognosis in human glioblastomas

1992 • 72 citations

Epidermal growth factor receptor expression and growth fraction in human tumours of the nervous system

1989 • 65 citations

Breast cancer cell kinetics: immunocytochemical determination of growth fractions by monoclonal antibody Ki-67 and correlation with flow cytometric S-phase and with some features of tumor aggressiveness.

1991 • 52 citations

Expression of epidermal growth factor receptors (EGFR) on breast carcinomas in relation to growth fractions, estrogen receptor status and morphological criteria. An immunohistochemical study.

1988 • 51 citations

Molecular genetics of human cancer predisposition and progression

1991 • 47 citations

DNA flow cytometry of human breast carcinomas and its relationship to transferrin and epidermal growth factor receptors

1986 • 42 citations

Cellular and tumoural heterogeneity of EGFR gene amplification in human malignant gliomas

1990 • 41 citations

Amplification of the epidermal growth factor receptor gene in human gliomas.

1991 • 28 citations

Immunocytochemistry and in situ hybridisation of epidermal growth factor receptor and relation to prognostic factors in breast cancer

1992 • 17 citations

Heterogeneity and modulation of tumor-associated antigens in human glioblastoma cell lines

1989 • 16 citations

Proliferative activity of normal and neoplastic urothelium and its relation to epidermal growth factor and transferrin receptors.

1993 • 12 citations

Characterization of node-negative breast cancer by clinico-pathologic and biologic factors.

1990 • 5 citations

Expression of epidermal growth factor receptor in human breast carcinoma and its correlation with morphological and biological features of tumour aggressiveness.

1989 • 4 citations