Cell Volume Regulatory Ion Transport in the Regulation of Cell Migration

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

Cellular Motility Driven by Assembly and Disassembly of Actin Filaments

2003 • 4,038 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

RHO GTPASES: Biochemistry and Biology

2005 • 2,891 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

Functional Significance of Cell Volume Regulatory Mechanisms

1998 • 1,871 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

2004 • 1,330 citations

Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia

1999 • 1,150 citations

The role of the Rho GTPases in neuronal development

2005 • 960 citations

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis

2005 • 849 citations

Two Distinct Actin Networks Drive the Protrusion of Migrating Cells

2004 • 799 citations

Actin microfilament dynamics in locomoting cells

1991 • 789 citations

Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating Fibroblasts

2001 • 724 citations

Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells

2003 • 658 citations

Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor

1997 • 652 citations

Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility

2004 • 652 citations

Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity

2002 • 646 citations

More than just water channels: unexpected cellular roles of aquaporins

2005 • 593 citations

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

1995 • 555 citations

Cortical Flow in Animal Cells

1988 • 554 citations

Actin machinery: pushing the envelope

2000 • 458 citations

Life at the Leading Edge: The Formation of Cell Protrusions

1993 • 442 citations

Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1

2002 • 421 citations

Direct Binding of the Na–H Exchanger NHE1 to ERM Proteins Regulates the Cortical Cytoskeleton and Cell Shape Independently of H+ Translocation

2000 • 407 citations

CD44 Interaction with Na+-H+ Exchanger (NHE1) Creates Acidic Microenvironments Leading to Hyaluronidase-2 and Cathepsin B Activation and Breast Tumor Cell Invasion

2004 • 397 citations

Cell migration at a glance

2005 • 370 citations

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.

1991 • 368 citations

Structure and function of the platelet integrin IIb 3

2005 • 332 citations

The Directed Migration of Eukaryotic Cells

1986 • 312 citations

Modulation of Glioma Cell Migration and Invasion Using Cl⁻and K⁺Ion Channel Blockers

1999 • 295 citations

Calcium Gradients Underlying Polarization and Chemotaxis of Eosinophils

1991 • 283 citations

Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations

1998 • 269 citations

Signaling in Leukocyte Transendothelial Migration

2004 • 252 citations

Control of intracellular pH and growth by fibronectin in capillary endothelial cells.

1990 • 241 citations

A Role for AQP5 in Activation of TRPV4 by Hypotonicity

2006 • 237 citations

Actin filament organization in the fish keratocyte lamellipodium.

1995 • 236 citations

Na–H Exchange Acts Downstream of RhoA to Regulate Integrin-induced Cell Adhesion and Spreading

1998 • 199 citations

The Physics of Cell Motility

1987 • 190 citations

Focal localization of the NHE-1 isoform of the Na+/H+ antiport: assessment of effects on intracellular pH.

1993 • 189 citations

Volume-Activated Chloride Currents Contribute to the Resting Conductance and Invasive Migration of Human Glioma Cells

2001 • 186 citations

Migration of human melanoma cells depends on extracellular pH and Na⁺/H⁺ exchange

2005 • 181 citations

Patterns of elevated free calcium and calmodulin activation in living cells

1992 • 177 citations

Ion fluxes during the action potential in Chara

1958 • 168 citations

A role for ion channels in glioma cell invasion.

2006 • 166 citations

Multiple integrins share the ability to induce elevation of intracellular pH*1

1991 • 161 citations

Regulation of the formation of tumor cell pseudopodia by the Na+/H+ exchanger NHE1

2000 • 159 citations

Function and spatial distribution of ion channels and transporters in cell migration

2001 • 148 citations

Actin-binding protein contributes to cell volume regulatory ion channel activation in melanoma cells.

1993 • 142 citations

Anion Channels, Including ClC-3, Are Required for Normal Neutrophil Oxidative Function, Phagocytosis, and Transendothelial Migration

2006 • 137 citations

Proton secretion by stimulated neutrophils. Significance of hexose monophosphate shunt activity as source of electrons and protons for the respiratory burst.

1984 • 135 citations

Effect of cell spreading on cytoplasmic pH in normal and transformed fibroblasts.

1989 • 131 citations

Intracellular pH regulation during spreading of human neutrophils.

1996 • 128 citations

Polarization of Na+/H+ and Cl−/Hco 3− Exchangers in Migrating Renal Epithelial Cells

2000 • 128 citations

Migration-associated volume changes in neutrophils facilitate the migratory process in vitro

1994 • 123 citations

Osmotic and phorbol ester-induced activation of Na+/H+ exchange: possible role of protein phosphorylation in lymphocyte volume regulation.

1985 • 117 citations

Molecular and functional aspects of anionic channels activated during regulatory volume decrease in mammalian cells*

2002 • 114 citations

Amiloride-sensitive Na+/H+ exchange in human neutrophils: Mechanism of activation by chemotactic factors

1984 • 111 citations

The Na+/H+ exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death

2006 • 110 citations

Activation of vacuolar-type proton pumps by protein kinase C. Role in neutrophil pH regulation

1992 • 110 citations

ATP dependence of NHE-1, the ubiquitous isoform of the Na+/H+ antiporter. Analysis of phosphorylation and subcellular localization.

1994 • 107 citations

Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance.

2003 • 105 citations

TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells

2004 • 105 citations

Volume dynamics in migrating epithelial cells measured with atomic force microscopy

1999 • 102 citations

Migration of transformed renal epithelial cells is regulated by K + channel modulation of actin cytoskeleton and cell volume

1999 • 96 citations

The Platelet: Form and Function

2006 • 95 citations

Protein kinase C activates an H+ (equivalent) conductance in the plasma membrane of human neutrophils.

1991 • 92 citations

The Na+–H+exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells

2004 • 91 citations

How do cells move along surfaces?

1993 • 87 citations

Oscillating activity of a Ca(2+)-sensitive K+ channel. A prerequisite for migration of transformed Madin-Darby canine kidney focus cells.

1994 • 84 citations

Signaling Mechanisms in Growth Factor‐Stimulated Cell Motility

1997 • 84 citations

Effect of inhibitors of Na⁺/H⁺‐exchange and gastric H⁺/K⁺ ATPase on cell volume, intracellular pH and migration of human polymorphonuclear leucocytes

1998 • 83 citations

Subcellular distribution of calcium‐sensitive potassium channels (IK1) in migrating cells

2005 • 79 citations

Intracellular calcium levels correlate with speed and persistent forward motion in migrating neutrophils

1995 • 79 citations

Ion Channels and Transporters on the Move

2001 • 78 citations

K<sup>+</sup> Channel-Dependent Migration of Fibroblasts and Human Melanoma Cells

1999 • 74 citations

Aquaporins in endothelia

2006 • 69 citations

Na<sup>+</sup>/H<sup>+</sup>Exchangers: Linking Osmotic Dysequilibrium to Modified Cell Function

2001 • 69 citations

Volume regulation in leukocytes: Requirement for an intact cytoskeleton

1995 • 67 citations

Actin and the coordination of protrusion, attachment and retraction in cell crawling

1996 • 66 citations

Chloride ion efflux regulates adherence, spreading, and respiratory burst of neutrophils stimulated by tumor necrosis factor-alpha (TNF) on biologic surfaces.

1996 • 66 citations

Circulation of the Plasma Membrane inDictyostelium

1999 • 66 citations

Na-K-2Cl cotransport in intestinal epithelial cells. Influence of chloride efflux and F-actin on regulation of cotransporter activity and bumetanide binding.

1994 • 65 citations

ICln, a Novel Integrin αIIbβ3-Associated Protein, Functionally Regulates Platelet Activation

2004 • 65 citations

Mediation of chemoattractant-induced changes in [Ca2+]i and cell shape, polarity, and locomotion by InsP3, DAG, and protein kinase C in newt eosinophils.

1994 • 64 citations

Polarized ion transport during migration of transformed Madin-Darby canine kidney cells

1995 • 62 citations

Activation of the Na+/K+/Cl/− contransport system by reorganization of the actin filaments in Ehrlich ascites tumor cells

1992 • 62 citations

Functional role of Na⁺–HCO₃⁻ cotransport in migration of transformed renal epithelial cells

2005 • 61 citations

Control of cell volume in the J774 macrophage by microtubule disassembly and cyclic AMP

1981 • 59 citations

Responses of growth cones to changes in osmolality of the surrounding medium

1991 • 56 citations

Neutrophil volume distribution width : A new automated hematologic parameter for acute infection

2006 • 56 citations

Cell Swelling Stimulates Cytosol to Membrane Transposition of ICln

2003 • 56 citations

Regulation of a Calcium-sensitive K+ Channel (cIK1) by Protein Kinase C

2002 • 50 citations

Abnormal activation of H+ conductance in NADPH oxidase-defective neutrophils.

1993 • 49 citations

Mechanics of crawling cells

2005 • 49 citations

Serum regulates Na+/H+ exchange in Caco-2 cells by a mechanism which is dependent on F-actin.

1992 • 48 citations

The Role of Ca<sup>2+</sup> Transport Across the Plasma Membrane for Cell Migration

2005 • 48 citations

Role in neuronal cell migration for high-threshold potassium currents in the chicken hindbrain

1999 • 47 citations

Imaging the lamellipodium of migrating epithelial cells in vivo by atomic force microscopy

1993 • 46 citations

The Nomenclature of Chemokines

1995 • 46 citations

Cl– channels are expressed in human normal monocytes: a functional role in migration, adhesion and volume change

2004 • 43 citations

Molecular genetics of cell migration: Dictyostelium as a model system

1991 • 41 citations

Involvement of regulatory volume decrease in the migration of nasopharyngeal carcinoma cells

2005 • 39 citations

Regulation by nerve growth factor and protein phosphorylation of Na/K/2Cl cotransport and cell volume in PC12 cells.

1994 • 38 citations

Axon guidance receptors direct growth cone pathfinding: rivalry at the leading edge.

2002 • 34 citations

Glucose Induces Anion Conductance and Cytosol-To-Membrane Transposition of ICln in INS-1E Rat Insulinoma Cells

2006 • 33 citations

Migrating transformed MDCK cells are able to structurally polarize a voltage-activated K ⁺ channel

1998 • 29 citations

Understanding the cortex of crawling cells: insights from Dictyostelium

1993 • 29 citations

Volume changes induced in rabbit polymorphonuclear leukocytes by chemotactic factor and cytochalasin B.

1975 • 27 citations

Regulation of cardiac volume-sensitive chloride channel by focal adhesion kinase and Src kinase

2005 • 26 citations

Actin and cell movement.

1993 • 25 citations

The ICln interactome

2006 • 23 citations

Extracellular detection of K + release during migration of transformed Madin-Darby canine kidney cells

1996 • 21 citations

Effects of bradykinin on cell volume and intracellular pH in NIH 3T3 fibroblasts expressing the ras oncogene

1992 • 21 citations

Ionic control of locomotion and shape of epithelial cells: II. Role of monovalent cations

1988 • 21 citations

Cytoplasmic Ca2+ determines the rate of Ca2+ entry into Mardin-Darby canine kidney-focus (MDCK-F) cells

1994 • 19 citations

Complex regulation of human neutrophil activation by actin filaments: dihydrocytochalasin B and botulinum C2 toxin uncover the existence of multiple cation entry pathways

1997 • 16 citations

Volume-activated Cl- current in migrated nasopharyngeal carcinoma cells.

2004 • 12 citations

Cell Volume Regulatory Ion Transport in Cell Migration

1998 • 11 citations

Blockade of chloride conductance antagonizes PMA-induced ramification in the murine microglial cell line, BV-2

2005 • 11 citations

Chapter 6 Monovalent Ion Transport and Membrane Potential Changes during Activation in Phagocytic Leukocytes

1990 • 10 citations

Involvement of Cyclic Adenosine Monophosphate-Dependent Protein Kinase A and Pertussis Toxin-Sensitive G Proteins in the Migratory Response of Human CD14+ Mononuclear Cells to Katacalcin

2002 • 10 citations